Výsledky vyhledávání - "Ulrich Bothe"

Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:3372-3375

We report here the design and synthesis of a novel series of benzylamines that are potent and selective inhibitors of uPA with promising oral availability in rat. Further evaluation of one representative (ZK824859) of the new structural class showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b761e7a2ae7d063c07c5d293801b02
https://doi.org/10.1016/j.bmcl.2018.09.001

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Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis

Autor: Stefan Bäurle, Olaf Peters, Gernot Langer, Ludwig Zorn, Antonius Ter Laak, Nico Bräuer, Ulrich Bothe, Daryl S. Walter, Jens Nagel, Thomas M. Zollner, Thorsten Blume, Cornelia Preusse, Antje Rottmann, Andreas Steinmeyer, Dieter Heldmann

Publikováno v: Journal of medicinal chemistry. 62(5)

The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes-the latter being frequently associated with severe, acute, and chronic pelvic pain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e5e05b956c3b01375f513a8d2d40bc
https://pubmed.ncbi.nlm.nih.gov/30707023

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A novel stereoselective synthesis of N-heterocycles by intramolecular hydrovinylationElectronic supplementary information (ESI) available: 1H and 13C NMR spectra of compounds 1a–f, 2a–d, 3–5, 8–10. See http://www.rsc.org/suppdata/p1/b1/b108310d

Autor: Mogens Johannsen, David Tanner, Ulrich Bothe, Hans Christian Rudbeck

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :3305-3311

A novel method for the synthesis of bicyclic amines has been developed. Cyclisation of 1,6-dienes by intramolecular hydrovinylation in the presence of catalytic amounts of allylpalladium chloride dimer afforded bicyclic amines in one step. Added phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ac6a5a3fed4136e9cbaa8686183daa8
https://doi.org/10.1039/b108310d

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Carboranyl Bisglycosides for the Treatment of Cancer by Boron Neutron Capture Therapy

Autor: Ulrich Griesbach, Ulrich Bothe, Hiroyuki Nakamura, Munekazu Nakaichi, Lutz F. Tietze, Yoshinori Yamamoto, Toshinari Hasegawa

Publikováno v: ChemBioChem. 2:326-334

Boron neutron capture therapy is a special type of radiotherapy for the treatment of cancer by using boron compounds. Problems often arise from the low water solubility of these compounds, their unselective uptake into the cancer cells, and their tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844827210ebb382331ed240a795d716d
https://doi.org/10.1002/1439-7633(20010504)2:5<326::aid-cbic326>3.0.co

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Preparation of a New Carboranyl Lactoside for the Treatment of Cancer by Boron Neutron Capture Therapy: Synthesis and Toxicity of Fluoro Carboranyl Glycosides for in vivo19F-NMR Spectroscopy

Autor: Ulrich Bothe, Lutz F. Tietze, Ingrid Schuberth

Publikováno v: Chemistry - A European Journal. 6:836-842

The synthesis of new ortho-carboranyl lactosides 8, 17, 19 and glucosides 22 and 23 for the use in boron neutron capture therapy is reported. Carboranyl lactosides 17 and 19 as well as the glucosides 22 and 23 contain a fluorine atom to allow a nonin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e315c2b34c8396155dbde99239aab6d
https://doi.org/10.1002/(sici)1521-3765(20000303)6:5<836::aid-chem836>3.0.co

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Ortho-Carboranyl Glycosides of Glucose, Mannose, Maltose and Lactose for Cancer Treatment by Boron Neutron-Capture Therapy

Autor: Lutz F. Tietze, Ulrich Bothe

Publikováno v: Chemistry - A European Journal. 4:1179-1183

A short synthesis of novel carboranyl glycosides such as the one on the right for use in the treatment of cancer by boron neutron-capture therapy is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a59cfcc00297726ca9c0264b9a6463a
https://doi.org/10.1002/(sici)1521-3765(19980710)4:7<1179::aid-chem1179>3.0.co

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ChemInform Abstract: A Novel Stereoselective Synthesis of N-Heterocycles by Intramolecular Hydrovinylation

Autor: Hans Christian Rudbeck, Ulrich Bothe, Mogens Johannsen, David Tanner

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff033193514ff93c587699ca1d3082dc
https://doi.org/10.1002/chin.200216136

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ChemInform Abstract: Novel Carboranes with a DNA Binding Unit for the Treatment of Cancer by Boron Neutron Capture Therapy

Autor: Lutz F. Tietze, Yoshinori Yamamoto, Ulrich Bothe, Hiroyuki Nakamura, Ulrich Griesbach

Publikováno v: ChemInform. 33

The synthesis and biological evaluation of two ortho-carborane derivatives which contain a 5,6,7-trimethoxyindole (TMI) unit for use in boron neutron capture therapy is described. The TMI moiety is known to be the DNA-binding part of the highly poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::651fe6f9589bcae8bd055c38e0bf3055
https://doi.org/10.1002/chin.200220141

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