Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Ulrich Bierbach"'
Autor:
Haoqing Wu, Ulrich Bierbach
Publikováno v:
ChemMedChem. 17(18)
Growth inhibition (GI) and gene expression profiles across the 60 cell lines of the NCI-60 screen were analyzed to elucidate mechanistic differences between a nucleolus-targeting platinum-acridine (PA) hybrid anticancer agent (compound 1) and the sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00af222af62be0658af0caac3c356435
https://pubmed.ncbi.nlm.nih.gov/35902361
https://pubmed.ncbi.nlm.nih.gov/35902361
Autor:
Ulrich Bierbach, Shenjie Zhang, Sofia R. Caruso, Noah H. Watkins, P. Keegan Rose, Cynthia S. Day, Xiyuan Yao
Publikováno v:
Angew Chem Int Ed Engl
A structure-activity relationship study was performed for a set of rigidified platinum-acridine anticancer agents containing linkers derived from chiral pyrrolidine and piperidine scaffolds. Screening a library of microscale reactions and selected re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bbf9fbf50f840dc43bc6f16def9114
https://doi.org/10.1002/anie.202009983
https://doi.org/10.1002/anie.202009983
Autor:
Adam T. Green, Amanda J. Pickard, Rongzhong Li, Alexander D. MacKerell, Ulrich Bierbach, Samuel S. Cho
Publikováno v:
J Phys Chem B
DNA G-quadruplexes in human telomeres and gene promoters are being extensively studied for their role in controlling the growth of cancer cells. G-quadruplexes have been unambiguously shown to exist both in vitro and in vivo, including in the guanine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4495938a7e3c1aa2ee97f239c5f905c8
https://pubmed.ncbi.nlm.nih.gov/35026949
https://pubmed.ncbi.nlm.nih.gov/35026949
Autor:
John T. Sloop, P. Keegan Rose, George L. Donati, Shenjie Zhang, Xiyuan Yao, Cynthia S. Day, Ikeer Y. Mancera-Ortiz, Noah H. Watkins, Ulrich Bierbach
Publikováno v:
Inorganica Chimica Acta. 492:150-155
Three new derivatives of a platinum–acridine hybrid anticancer agent were synthesized using nitrile–amine coupling (amidination) chemistry. In the new structures, the nonleaving group propane-1,3-diamine (pn) of a previously optimized analogue (h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed8fa46ba8e89692c374dd1d6d48cc7
https://doi.org/10.1016/j.ica.2019.04.030
https://doi.org/10.1016/j.ica.2019.04.030
Publikováno v:
Inorganic Chemistry. 58:43-46
Classical maleimide Michael addition chemistry in conjunction with copper-free click chemistry was investigated as a synthetic strategy to attach cytotoxic platinum–acridine hybrid agents to carrier proteins. The structural integrity and selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ceacc8022dc705f878ac344dea95e9c
https://doi.org/10.1021/acs.inorgchem.8b02717
https://doi.org/10.1021/acs.inorgchem.8b02717
Publikováno v:
ChemMedChem
Liposomal formulations have been developed for a highly cytotoxic platinum–acridine hybrid agent, [PtCl(pn)(C18H21N4)](NO3)2 (PA, pn = propane-1,3-diamine), and fully characterized. PEGylated nanoliposomes consisting of hydrogenated soybean phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ca304fad884cf9c3fbfc7172332a58
https://pubmed.ncbi.nlm.nih.gov/32975041
https://pubmed.ncbi.nlm.nih.gov/32975041
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feff5782a5b49744d079ff59edb8a90c
https://pubmed.ncbi.nlm.nih.gov/32939009
https://pubmed.ncbi.nlm.nih.gov/32939009
Autor:
Cristina M. Furdui, Karen S. Anderson, Y. G. Kim, Lucas A Gabriel, Mu Yang, Hanzhi Wu, Julie Chu, Ulrich Bierbach
Publikováno v:
Chemical Communications. 54:7479-7482
Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a67e1db7e8a8f1727e5ba700b6e71a9
https://doi.org/10.1039/c8cc04251a
https://doi.org/10.1039/c8cc04251a