Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Ulrich BLANK"'
Autor:
John TCHEN, Quentin SIMON, Léa CHAPART, Morgane K. THAMINY, Shamila VIBHUSHAN, Loredana SAVEANU, Yasmine LAMRI, Fanny SAIDOUNE, Emeline PACREAU, Christophe PELLEFIGUES, Julie BEX-COUDRAT, Hajime KARASUYAMA, Kensuke MIYAKE, Juan HIDALGO, Padraic G. FALLON, Thomas PAPO, Ulrich BLANK, Marc BENHAMOU, Guillaume HANOUNA, Karim SACRE, Eric DAUGAS, Nicolas CHARLES
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary
Externí odkaz:
https://doaj.org/article/2b261c12033c4401a2b53ad4f143bfa7
Autor:
Ulrich Blank, Carlo Pucillo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/d4484c7281b74d1e824505e9a32d7aa0
Autor:
Manuela Bratti, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The function of intracellular trafficking in immune-complex triggered inflammation remains poorly understood. Here, we investigated the role of Insulin-Regulated Amino Peptidase (IRAP)-positive endosomal compartments in Fc receptor (FcR)-induced infl
Externí odkaz:
https://doaj.org/article/3faaf41d039145589aa4626bfa0fc628
Autor:
John Tchen, Quentin Simon, Léa Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tissue-specific mouse models are essential tools to decipher the role of each cell compartment and/or their expressed genes in the pathophysiology of diseases. Here, we describe a new knock-in mouse model allowing expression of both the fluorescent p
Externí odkaz:
https://doaj.org/article/6d84a6fd725646d891b31d23a059b29f
Publikováno v:
Cells, Vol 11, Iss 19, p 3055 (2022)
Mast cells (MCs) are well-known for their role in IgE-mediated cutaneous anaphylactic responses, but their regulatory functions in the skin are still under intense scrutiny. Using a Red MC and Basophil reporter (RMB) mouse allowing red fluorescent de
Externí odkaz:
https://doaj.org/article/2e970a965f8b4e9c880b7ae1a14c2fc6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mast cells are well known for their role in allergies and many chronic inflammatory diseases. They release upon stimulation, e.g., via the IgE receptor, numerous bioactive compounds from cytoplasmic secretory granules. The regulation of granule secre
Externí odkaz:
https://doaj.org/article/83abfccbec5241f4a35db98b73103e3a
Autor:
Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, Dimitri Titeca-Beauport, Carine Bounaix, Luca Danelli, Pierre Launay, Marc Benhamou, Ulrich Blank, Eric Daugas, Nicolas Charles, Renato C. Monteiro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.
Externí odkaz:
https://doaj.org/article/018c8dd96b534ef981f995c3443a4374
Autor:
Shamila Vibhushan, Manuela Bratti, Juan Eduardo Montero-Hernández, Alaa El Ghoneimi, Marc Benhamou, Nicolas Charles, Eric Daugas, Ulrich Blank
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 302 (2020)
A sizable part (~2%) of the human genome encodes for proteases. They are involved in many physiological processes, such as development, reproduction and inflammation, but also play a role in pathology. Mast cells (MC) contain a variety of MC specific
Externí odkaz:
https://doaj.org/article/2a3ec03afd2d4b499c916061d5bc3657
Autor:
Flavie Ngo Nyekel, Emeline Pacreau, Samira Benadda, Rasha Msallam, Magnus Åbrink, Gunnar Pejler, Jean Davoust, Marc Benhamou, Nicolas Charles, Pierre Launay, Ulrich Blank, Gregory Gautier
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Recent evidences indicate an important role of tissue inflammatory responses by innate immune cells in allograft acceptance and survival. Here we investigated the role of mast cells (MC) in an acute male to female skin allograft rejection model using
Externí odkaz:
https://doaj.org/article/19eba69396d14f69908173f038c7f8cf
Autor:
Maguelonne Pons, Liza Ali, Walid Beghdadi, Luca Danelli, Marianne Alison, Lydia Celia Madjène, Jessica Calvo, Julien Claver, Shamila Vibhushan, Magnus Åbrink, Gunnar Pejler, Marie-Laurence Poli-Mérol, Michel Peuchmaur, Alaa El Ghoneimi, Ulrich Blank
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions are reproduced using a model of partial unilateral ureteral o
Externí odkaz:
https://doaj.org/article/718c8dfc53b1486eaf7e0a30d152f048