Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Ulrich Auf dem Keller"'
Autor:
Helena Aagaard Laybourn, Chrysillis Hellemann Polhaus, Charlotte Kristensen, Betina Lyngfeldt Henriksen, Yaolei Zhang, Louise Brogaard, Cathrine Agnete Larsen, Ramona Trebbien, Lars Erik Larsen, Konstantinos Kalogeropoulos, Ulrich auf dem Keller, Kerstin Skovgaard
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInfluenza A virus (IAV) infection is a global respiratory disease, which annually leads to 3-5 million cases of severe illness, resulting in 290,000-650,000 deaths. Additionally, during the past century, four global IAV pandemics have cla
Externí odkaz:
https://doaj.org/article/c941eba2bb0c416c9f3bd99da0c06fc8
Autor:
Jun Cai, Maike W. Nielsen, Konstantinos Kalogeropoulos, Ulrich auf dem Keller, Mariena J.A. van der Plas
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109005- (2024)
Summary: Endogenous and bacterial proteases play important roles in wound healing and infection. Analysis of alterations in the low-molecular-weight peptidome by individual enzymes could therefore provide insight into proteolytic events occurring in
Externí odkaz:
https://doaj.org/article/d9c04a3b07de4f3187ac92e8cea299ce
Autor:
Valdemaras Petrosius, Pedro Aragon-Fernandez, Nil Üresin, Gergo Kovacs, Teeradon Phlairaharn, Benjamin Furtwängler, Jeff Op De Beeck, Sarah L. Skovbakke, Steffen Goletz, Simon Francis Thomsen, Ulrich auf dem Keller, Kedar N. Natarajan, Bo T. Porse, Erwin M. Schoof
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-state heterogeneity and distinct cellular signaling patterns that remain obscured with population-based techniques. The limited amount of material e
Externí odkaz:
https://doaj.org/article/14054e0093804c9391743fbe1ba55ea0
Autor:
Shayin V. Gibson, Elena Tomas Bort, Lucía Rodríguez-Fernández, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Ulrich auf dem Keller, Andrea Agnoletto, Cathrin Brisken, Barrie Peck, Angus J. Cameron, John F. Marshall, J. Louise Jones, Edward P. Carter, Richard P. Grose
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus p
Externí odkaz:
https://doaj.org/article/121dd275e1f548edb93a722fbf4391bf
Autor:
Cristina Ortiz, Sabine Klein, Winfried H. Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank E. Uschner, Sandra Torres, Christoph Hieber, Caroline Meier, Nico Kraus, Olaf Tyc, Maximilian Brol, Stefan Zeuzem, Christoph Welsch, Marco Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Fabio Mira, Ulrich auf dem Keller, Anja Tetzner, Andrew Moore, Thomas Walther, Jonel Trebicka
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112059- (2023)
Summary: Development of liver fibrosis is paralleled by contraction of hepatic stellate cells (HSCs), the main profibrotic hepatic cells. Yet, little is known about the interplay of neprilysin (NEP) and its substrate neuropeptide Y (NPY), a potent en
Externí odkaz:
https://doaj.org/article/5733bb5802fd4f15923c9bfe812518bf
Autor:
Jacek Mikosiński, Konstantinos Kalogeropoulos, Louise Bundgaard, Cathrine Agnete Larsen, Simonas Savickas, Aleksander Moldt Haack, Konrad Pańczak, Katarzyna Rybołowicz, Tomasz Grzela, Michał Olszewski, Piotr Ciszewski, Karina Sitek-Ziółkowska, Krystyna Twardowska-Saucha, Marek Karczewski, Daniel Rabczenko, Agnieszka Segiet, Patrycja Buczak-Kula, Erwin M. Schoof, Sabine A. Eming, Hans Smola, Ulrich auf dem Keller
Publikováno v:
Acta Dermato-Venereologica, Vol 102 (2022)
Venous leg ulcers represent a clinical challenge and impair the quality of life of patients. This study examines impaired wound healing in venous leg ulcers at the molecular level. Protein expression patterns for biomarkers were analysed in venous le
Externí odkaz:
https://doaj.org/article/31658718b32f49b98ef383dab62ffeef
Autor:
Sebastian P. Gnosa, Laia Puig Blasco, Krzysztof B. Piotrowski, Marie L. Freiberg, Simonas Savickas, Daniel H. Madsen, Ulrich auf dem Keller, Pauliina Kronqvist, Marie Kveiborg
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Macrophages in the tumor microenvironment have a substantial impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can either support or constrain tumor progression. It is therefore of therapeutic interest to i
Externí odkaz:
https://doaj.org/article/547b465088234ab986779c66c345bdc4
Autor:
Erwin M. Schoof, Benjamin Furtwängler, Nil Üresin, Nicolas Rapin, Simonas Savickas, Coline Gentil, Eric Lechman, Ulrich auf dem Keller, John E. Dick, Bo T. Porse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Single-cell proteomics can provide insights into the molecular basis for cellular heterogeneity. Here, the authors develop a multiplexed single-cell proteomics and computational workflow, and show that their strategy captures the cellular hierarchies
Externí odkaz:
https://doaj.org/article/e6eed179838c43b99f45da74c1d34042
Autor:
Federico Uliana, Matej Vizovišek, Laura Acquasaliente, Rodolfo Ciuffa, Andrea Fossati, Fabian Frommelt, Sandra Goetze, Bernd Wollscheid, Matthias Gstaiger, Vincenzo De Filippis, Ulrich auf dem Keller, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Characterizing proteases in their native environment is still challenging. Here, the authors develop a proteomics workflow for analyzing protease-specific peptides from cell lysates in 96-well format, providing mechanistic insights into blood proteas
Externí odkaz:
https://doaj.org/article/db933c0d43874f78b25c2f9000538975
Autor:
Manuela B. Pucca, Shirin Ahmadi, Felipe A. Cerni, Line Ledsgaard, Christoffer V. Sørensen, Farrell T. S. McGeoghan, Trenton Stewart, Erwin Schoof, Bruno Lomonte, Ulrich auf dem Keller, Eliane C. Arantes, Figen Çalışkan, Andreas H. Laustsen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Toxin synergism is a complex biochemical phenomenon, where different animal venom proteins interact either directly or indirectly to potentiate toxicity to a level that is above the sum of the toxicities of the individual toxins. This provides the an
Externí odkaz:
https://doaj.org/article/f708fbc151bd4462b01ad31680dc485f