Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Ulrich, Schraermeyer"'
Autor:
Shiying Zhao, Alexander V. Tschulakow, Subha S. Karthikeyan, Kun Wang, Stefan Kochanek, Ulrich Schraermeyer, Sylvie Julien‐Schraermeyer
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 311-326 (2024)
Abstract Retinopathy of prematurity (ROP) is a severe retinal disease in premature infants characterized by pathological neovascularization, obliteration of retinal vessels and increased vessel tortuosity. Currently, there are no completely satisfact
Externí odkaz:
https://doaj.org/article/2a9b5bffc3bc4994b1a7b2044bb000bb
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Lipofuscin is a representative biomarker of aging that is generated naturally over time. Remofuscin (soraprazan) improves age-related eye diseases by removing lipofuscin from retinal pigment epithelium (RPE) cells. In this study, the effect
Externí odkaz:
https://doaj.org/article/6d68113d8a2e4de2aaba55d7f00d9217
Autor:
Tatjana Taubitz, Yuan Fang, Antje Biesemeier, Sylvie Julien-Schraermeyer, Ulrich Schraermeyer
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 592-604 (2019)
Background: Fundus autofluorescence is a non-invasive imaging technique in ophthalmology. Conventionally, short-wavelength autofluorescence (SW-AF) is used for detection of lipofuscin, a byproduct of the visual cycle which accumulates with age or dis
Externí odkaz:
https://doaj.org/article/eb0527a53d2a4e118e862e04d99f88be
Autor:
Sylvie Julien‐Schraermeyer, Barbara Illing, Alexander Tschulakow, Tatjana Taubitz, Jamil Guezguez, Michael Burnet, Ulrich Schraermeyer
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
Abstract Age‐related macular degeneration (AMD) is the leading cause of blindness in older people in the developed world while Stargardt's disease (SD) is a juvenile macular degeneration and an orphan disease. Both diseases are untreatable and are
Externí odkaz:
https://doaj.org/article/c05310e24a8640c8a529cbc34b3eb077
Autor:
Shan Liu, Antje K. Biesemeier, Alexander V. Tschulakow, Harsh V. Thakkar, Sylvie Julien-Schraermeyer, Ulrich Schraermeyer
Publikováno v:
Biology Open, Vol 9, Iss 6 (2020)
Vascular endothelial growth factor (VEGF) is a crucial stimulator for choroidal neovascularization (CNV). Our aim was to develop a reproducible and valid treatment-naive quiescent CNV (i.e. without signs of exudation and with normal visual acuity) ra
Externí odkaz:
https://doaj.org/article/a0556454dbde49779f7d0dbfe0d5de39
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1332-1336 (2018)
The data presented in this article are related to the research paper entitled “The anatomy of the foveola reinvestigated” (Tschulakow et al., 2018) [1]. Here we show the original aligned serial sections through the foveal centre of monkeys at dif
Externí odkaz:
https://doaj.org/article/b5696693b83048999866d9230ac803e6
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Age-related macular degeneration, Stargardt disease, and their Abca4 -/- mouse model are characterized by accelerated accumulation of the pigment lipofuscin, derived from photoreceptor disc turnover in the retinal pigment epithelium (RPE); lipofuscin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10945002cce706ee0cb4d6dce0e752fe
https://doi.org/10.1073/pnas.2216935120
https://doi.org/10.1073/pnas.2216935120
Publikováno v:
Biology Open, Vol 5, Iss 11, Pp 1625-1630 (2016)
Retinoblastoma (Rb) is the most frequent primary intraocular tumour in children and, if left untreated, can cause death. Preclinical animal models that mimic molecular, genetic, and cellular features of cancers are essential for studying cancer and s
Externí odkaz:
https://doaj.org/article/bb3d69732baa4e30a894094b91ad4fd9
Publikováno v:
Guoji Yanke Zazhi, Vol 16, Iss 6, Pp 1014-1018 (2016)
AIM: To compare the effects on the retina inner segment and retinal pigment epithelium(RPE)of intravitreally injecting bevacizumab, ranibizumab and aflibercept into monkey eyes.METHODS: Fourteen healthy cynomolgus monkeys(Macaca fascicularis, aged 3-
Externí odkaz:
https://doaj.org/article/abae94441e09457bb523ba4acfb6b4c4
Autor:
Yuan Fang, Tatjana Taubitz, Alexander V. Tschulakow, Peter Heiduschka, Grzegorz Szewczyk, Michael Burnet, Tobias Peters, Antje Biesemeier, Tadeusz Sarna, Ulrich Schraermeyer, Sylvie Julien-Schraermeyer
Publikováno v:
Free Radical Biology and Medicine. 182:132-149
Accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging and is associated with retinal degeneration encountered in age-related macular degeneration (AMD) and Stargardt disease (SD). Currently, treatment for lipofusci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d83cab6b21ba4299447158da783a3f4
https://doi.org/10.1016/j.freeradbiomed.2022.02.025
https://doi.org/10.1016/j.freeradbiomed.2022.02.025