Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Ulrich, Rothbauer"'
Autor:
Desiree I. Frecot, Simone Blaess, Teresa R. Wagner, Philipp D. Kaiser, Bjoern Traenkle, Madeleine Fandrich, Meike Jakobi, Armin M. Scholz, Stefan Nueske, Nicole Schneiderhan-Marra, Cécile Gouttefangeas, Manfred Kneilling, Bernd J. Pichler, Dominik Sonanini, Ulrich Rothbauer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeHuman OX40 (hOX40/CD134), a member of the TNF receptor superfamily, is mainly expressed on activated T lymphocytes. Triggered by its ligand OX40L (CD252), it provides costimulatory signals that support the differentiation, proliferation and lo
Externí odkaz:
https://doaj.org/article/ce3a8aa1d9c443469359f03d31106fa0
Autor:
Teresa R. Wagner, Simone Blaess, Inga B. Leske, Desiree I. Frecot, Marius Gramlich, Bjoern Traenkle, Philipp D. Kaiser, Dominik Seyfried, Sandra Maier, Amélie Rezza, Fabiane Sônego, Kader Thiam, Stefania Pezzana, Anne Zeck, Cécile Gouttefangeas, Armin M. Scholz, Stefan Nueske, Andreas Maurer, Manfred Kneilling, Bernd J. Pichler, Dominik Sonanini, Ulrich Rothbauer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Signal-regulatory protein α (SIRPα) expressed by myeloid cells is of particular interest for therapeutic strategies targeting the interaction between SIRPα and the “don’t eat me” ligand CD47 and as a marker to monitor macrophage infiltration
Externí odkaz:
https://doaj.org/article/29efe43cd84c4093b9130cdff8fcf447
Autor:
Daniel Junker, Alex Dulovic, Matthias Becker, Teresa R. Wagner, Philipp D. Kaiser, Bjoern Traenkle, Katharina Kienzle, Stefanie Bunk, Carlotta Struemper, Helene Haeberle, Kristina Schmauder, Natalia Ruetalo, Nisar Malek, Karina Althaus, Michael Koeppen, Ulrich Rothbauer, Juliane S. Walz, Michael Schindler, Michael Bitzer, Siri Göpel, Nicole Schneiderhan-Marra
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest in the longevity of immune protection, especially with regard to increasingly infectious virus variants. Neutralizing antibodies (Nabs) targeting the re
Externí odkaz:
https://doaj.org/article/65541620e8964ed78cf2db87bc1b9e1e
Autor:
Alex Dulovic, Monika Strengert, Gema Morillas Ramos, Matthias Becker, Johanna Griesbaum, Daniel Junker, Karsten Lürken, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Anne Cossmann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra, Georg M.N. Behrens
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 4, Pp 743-750 (2022)
Patients undergoing chronic hemodialysis were among the first to receive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased risk for severe coronavirus disease and high case-fatality rates. By using a
Externí odkaz:
https://doaj.org/article/bf1f2ba9a9164267856bf376d78e8a99
Autor:
Romina J. Walter, Steffen J. Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M. Heneka, Thomas Loustau, Michael Hodder, Rachel A. Ridgway, Owen J. Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Véronique Orian-Rousseau
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-16 (2022)
Abstract Enhancement of Wnt signaling is fundamental for stem cell function during intestinal regeneration. Molecular modules control Wnt activity by regulating signal transduction. CD44 is such a positive regulator and a Wnt target gene. While highl
Externí odkaz:
https://doaj.org/article/ba60973a08064619990c359bff0a4f13
Autor:
Hanna Renk, Alex Dulovic, Alina Seidel, Matthias Becker, Dorit Fabricius, Maria Zernickel, Daniel Junker, Rüdiger Groß, Janis Müller, Alexander Hilger, Sebastian F. N. Bode, Linus Fritsch, Pauline Frieh, Anneke Haddad, Tessa Görne, Jonathan Remppis, Tina Ganzemueller, Andrea Dietz, Daniela Huzly, Hartmut Hengel, Klaus Kaier, Susanne Weber, Eva-Maria Jacobsen, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Maximilian Stich, Burkhard Tönshoff, Georg F. Hoffmann, Barbara Müller, Carolin Ludwig, Bernd Jahrsdörfer, Hubert Schrezenmeier, Andreas Peter, Sebastian Hörber, Thomas Iftner, Jan Münch, Thomas Stamminger, Hans-Jürgen Groß, Martin Wolkewitz, Corinna Engel, Weimin Liu, Marta Rizzi, Beatrice H. Hahn, Philipp Henneke, Axel R. Franz, Klaus-Michael Debatin, Nicole Schneiderhan-Marra, Ales Janda, Roland Elling
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist l
Externí odkaz:
https://doaj.org/article/af0bd9036d2c4e6cb0fbd39a1d97ce6a
Autor:
Tatu Pantsar, Philipp D. Kaiser, Mark Kudolo, Michael Forster, Ulrich Rothbauer, Stefan A. Laufer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The molecular determinants of the residence time of a small molecule inhibitor at its target protein are not well understood. Here, Pantsar et al. show that the target protein’s conformational stability and solvent exposure are key factors governin
Externí odkaz:
https://doaj.org/article/ea56edd9054540ceba1fbe3572b2db6f
Autor:
Matthias Becker, Anne Cossmann, Karsten Lürken, Daniel Junker, Jens Gruber, Jennifer Juengling, Gema Morillas Ramos, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra, Monika Strengert, Alex Dulovic, Georg M. N. Behrens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Haemodialysis patients respond poorly to vaccination and continue to be at-risk for severe COVID-19. Therefore, dialysis patients were among the first for which a fourth COVID-19 vaccination was recommended. However, targeted information on how to be
Externí odkaz:
https://doaj.org/article/c3c8a3ec127e47309ad52458e675fb17
Autor:
Sandra Burgstaller, Teresa R. Wagner, Helmut Bischof, Sarah Bueckle, Aman Padamsey, Desiree Frecot, Philipp D. Kaiser, David Skrabak, Roland Malli, Robert Lukowski, Ulrich Rothbauer
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104907- (2022)
Summary: Ion and analyte changes in the tumor microenvironment (TME) alter the metabolic activity of cancer cells, promote tumor cell growth, and impair anti-tumor immunity. Consequently, accurate determination and visualization of extracellular chan
Externí odkaz:
https://doaj.org/article/c93a87783219431f8eb4f7cb90e33442
Autor:
Matthias Becker, Alex Dulovic, Daniel Junker, Natalia Ruetalo, Philipp D. Kaiser, Yudi T. Pinilla, Constanze Heinzel, Julia Haering, Bjoern Traenkle, Teresa R. Wagner, Mirjam Layer, Martin Mehrlaender, Valbona Mirakaj, Jana Held, Hannes Planatscher, Katja Schenke-Layland, Gérard Krause, Monika Strengert, Tamam Bakchoul, Karina Althaus, Rolf Fendel, Andrea Kreidenweiss, Michael Koeppen, Ulrich Rothbauer, Michael Schindler, Nicole Schneiderhan-Marra
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Here, the authors characterize the antibody response from vaccinated (Pfizer BNT-162b2), infected and uninfected individuals against emerging variants of concern of SARS-CoV-2, finding reduced neutralization of a South African isolate. High IgG titer
Externí odkaz:
https://doaj.org/article/b1f0cfb4a3c942a594406b501e462f7e