Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Ulrich, Reineke"'
Autor:
Dirk Zboralski, Aileen Hoehne, Anne Bredenbeck, Anne Schumann, Minh Nguyen, Eberhard Schneider, Jan Ungewiss, Matthias Paschke, Christian Haase, Jan L. von Hacht, Tanya Kwan, Kevin K. Lin, Jan Lenore, Thomas C. Harding, Jim Xiao, Andrew D. Simmons, Ajay-Mohan Mohan, Nicola Beindorff, Ulrich Reineke, Christiane Smerling, Frank Osterkamp
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:3651-3667
Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers. FAP-2286 is a FAP-binding peptide coupled to a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4850c6231a32e27da84462b88a71eaaf
https://doi.org/10.1007/s00259-022-05842-5
https://doi.org/10.1007/s00259-022-05842-5
Autor:
Frankis Almaguel, Franz C Robiller, Aviral Singh, Dirk Mueller, Christiane Smerling, Maythinee Chantadisai, Aleksandr Eismant, Christiane Schuchardt, Jingjing Zhang, Frank Osterkamp, Aileen Hoehne, Dirk Zboralski, Ulrich Reineke, Richard P. Baum, Harshad R. Kulkarni
Publikováno v:
Journal of Nuclear Medicine. 63:415-423
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which can be labeled with radionuclides for theranostic applications. We present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35f8af36fef73ab6f39170d0ad64af2
https://doi.org/10.2967/jnumed.120.259192
https://doi.org/10.2967/jnumed.120.259192
Autor:
Richard P, Baum, Christiane, Schuchardt, Aviral, Singh, Maythinee, Chantadisai, Franz C, Robiller, Jingjing, Zhang, Dirk, Mueller, Alexander, Eismant, Frankis, Almaguel, Dirk, Zboralski, Frank, Osterkamp, Aileen, Hoehne, Ulrich, Reineke, Christiane, Smerling, Harshad R, Kulkarni
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 63(3)
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which can be labeled with radionuclides for theranostic applications. We present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9726e883d10727e7838d7dda778c736c
https://pubmed.ncbi.nlm.nih.gov/34168013
https://pubmed.ncbi.nlm.nih.gov/34168013
Autor:
Tanya T. Kwan, Minh Nguyen, Dirk Zboralski, Anne Schumann, Anne Bredenbeck, Matthias Paschke, Christian Haase, Aileen Hoehne, Ulrich Reineke, Christiane Smerling, Frank Osterkamp, Jim Xiao, Andrew D. Simmons, Thomas C. Harding, Kevin L. Lin
Publikováno v:
Molecular Cancer Therapeutics. 20:LBA032-LBA032
Background: FAP is a membrane-bound protease with limited expression in normal tissues but high expression on cancer-associated fibroblasts abundant in the stroma of most tumors. FAP-2286 is a potent and selective FAP-targeted peptide linked to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4919ec3ab51e23af228e1117a2d26a58
https://doi.org/10.1158/1535-7163.targ-21-lba032
https://doi.org/10.1158/1535-7163.targ-21-lba032
Autor:
Christiane Smerling, Ulrich Reineke, Christiane Schuchardt, Aviral Singh, Harshad R. Kulkarni, Richard P. Baum, Stefan Wiessalla, Frank Osterkamp, Ingo Klette
Publikováno v:
Journal of Nuclear Medicine. 59:809-814
Neurotensin receptor 1 (NTR1) is overexpressed in ductal pancreatic adenocarcinoma, which is still one of the deadliest cancers, with a very poor prognosis. Eligible patients were offered salvage radiopharmaceutical therapy with the novel NTR1 antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac3a07cb03a3c7b37ebf861f59b68f7
https://doi.org/10.2967/jnumed.117.193847
https://doi.org/10.2967/jnumed.117.193847
Autor:
Martin Rohracker, Christiane Smerling, Holger Amthauer, Aileen Höhne, Jürgen Goldschmidt, Anette Pethe, Mercedes Noriega, Ulrich Reineke, Marvin Stiebler, Jörg Schulz, Frank Osterkamp, Mathias Lukas, Franziska Stöber
Publikováno v:
Journal of Nuclear Medicine. 58:936-941
Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy. Using the favor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c490a9fee3ccf56b901a6cb975baadc
https://doi.org/10.2967/jnumed.116.185140
https://doi.org/10.2967/jnumed.116.185140
Autor:
Christiane Smerling, Ulrich Reineke, Marvin Stiebler, Annette Pethe, Jörg Schulz, Frank Osterkamp, Holger Amthauer, Oliver S. Grosser, Jürgen Goldschmidt, Martin Rohracker
Publikováno v:
Journal of Nuclear Medicine. 57:1120-1123
Neurotensin receptor-1 (NTR1) is a promising target for diagnostic imaging and targeted radionuclide therapy. The aim of this study was to evaluate the biodistribution profiles of a series of newly developed diarylpyrazole-based NTR1 antagonists rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e9415637ceeeae2a0329be69940e30
https://doi.org/10.2967/jnumed.115.170530
https://doi.org/10.2967/jnumed.115.170530
Publikováno v:
Angewandte Chemie (International ed. in English). 37(6)
A short peptide as mimic for the hemopoietic growth factor erythropoietin (containing 165 amino acids) could be identified with the aid of peptide libraries on phage surfaces (phage display). The crystal structure of a peptide dimer complexed with tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4fa457de4b7e0f21171d8ee254dfd0
https://pubmed.ncbi.nlm.nih.gov/29711402
https://pubmed.ncbi.nlm.nih.gov/29711402
Autor:
Markus Fries, Thomas Polakowski, Ulrich Reineke, Michael Dockal, M. Christella L. G. D. Thomassen, Friedrich Scheiflinger, Alexandra C.A. Heinzmann, Hans Brandstetter, Jan Rosing, Rudolf Hartmann, Hartmut J. Ehrlich, Andreas Griessner, Frank Osterkamp
Publikováno v:
Journal of Biological Chemistry, 289(3), 1732-1741. American Society for Biochemistry and Molecular Biology, Inc.
Background: Tissue factor pathway inhibitor (TFPI) inhibits coagulation factors Xa and VIIa. Results: A de novo synthesized 20-mer peptide that binds to TFPI was structurally and functionally characterized. Conclusion: The peptide binds to the Kunitz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c417746fda6fed38536cda97a288d87c
https://doi.org/10.1074/jbc.m113.533836
https://doi.org/10.1074/jbc.m113.533836
Autor:
Jörg, Schulz, Martin, Rohracker, Marvin, Stiebler, Jürgen, Goldschmidt, Franziska, Stöber, Mercedes, Noriega, Anette, Pethe, Mathias, Lukas, Frank, Osterkamp, Ulrich, Reineke, Aileen, Höhne, Christiane, Smerling, Holger, Amthauer
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 58(6)
Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy. Using the favor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e238eca8b92e8fdc525bf56a093188d8
https://pubmed.ncbi.nlm.nih.gov/28254866
https://pubmed.ncbi.nlm.nih.gov/28254866