Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Ulrich, Ebert"'
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 528-540 (2005)
Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein. We s
Externí odkaz:
https://doaj.org/article/864eb377dcd34dce819a1726c992b05d
Autor:
Wolfgang Löscher, Daniela A. Fux, Rudolf Scherkl, Marion Bankstahl, Alan Kovacevic, Ulrich Ebert, Hermann Ammer, Thomas A. Lutz, André Rex, Chris Rundfeldt, Jörg-Peter Voigt, Manuela Gernert, Joachim Geyer, Manfred Kietzmann, Heidrun Fink, Angelika Richter, Meike Mevissen, Hanspeter Nägeli, Heidrun Potschka, Getu Abraham, Andreas W. Herling, Wolfgang Bäumer, Hans-Hasso Frey, Walther Honscha, Melanie Hamann, Stephan Steuber, Veronika Sexl
Publikováno v:
Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ea0b446b4126eaa55f0af814064c27f
https://doi.org/10.1055/b-004-129671
https://doi.org/10.1055/b-004-129671
Autor:
Gerard B. Fox, Mark Day, Feng Luo, Ulrich Ebert, Vincent Hradil, Terese Seifert, Bryan F. Cox, Beate Roesner, Jean M. Severin, Heinz Hillen, Daniel A. Llano, Nathan R. Rustay
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:580-588
In recent years immunotherapy-based approaches for treating Alzheimer's disease have become the subject of intensive research. However, an important mechanistic-related safety concern is exacerbation of the risk of microhemorrhage that may be associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b13917328af39886dba23169e2206a
https://doi.org/10.1124/jpet.110.172932
https://doi.org/10.1124/jpet.110.172932
Autor:
Philip J. Hajduk, John E. Harlan, Ulrich Ebert, Robert W. Johnson, Stefan Barghorn, Larry R. Solomon, Thomas F. Holzman, Boris Labkovsky, Heinz Hillen, Edward T. Olejniczak, Rohinton Edalji, Karl A. Walter, Liping Yu, Paul L. Richardson, Laura J. Miesbauer, Diane Bartley, Ana Pereda Lopez
Publikováno v:
Biochemistry. 48:1870-1877
Alzheimer's disease (AD) is a neurodegenerative disorder that is linked to the presence of amyloid beta-peptides that can form insoluble fibrils or soluble oligomeric assemblies. Soluble forms are present in the brains and tissues of Alzheimer's pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457039242f221b4027522f6e3cf1430e
https://doi.org/10.1021/bi802046n
https://doi.org/10.1021/bi802046n
Autor:
Volker Nimmrich, Ulrich Ebert
Publikováno v:
Reviews in the Neurosciences. 20:1-12
Since Alois Alzheimer first described morphological alterations associated with his patient's dementia more than 100 years ago, Alzheimer's disease (AD) was defined as neurodegenerative disease caused by extracellular deposits of misfolded proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f563f6b2697993593e214fd95507b65
https://doi.org/10.1515/revneuro.2009.20.1.1
https://doi.org/10.1515/revneuro.2009.20.1.1
Publikováno v:
Neuroscience. 141:2177-2194
The piriform cortex (PC) is the largest region of the mammalian olfactory cortex with strong connections to other limbic structures, including the amygdala, hippocampus, and entorhinal cortex. In addition to its functional importance in the classific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f56f32a1c70ee65091dee7c9d56e38
https://doi.org/10.1016/j.neuroscience.2006.05.040
https://doi.org/10.1016/j.neuroscience.2006.05.040
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 528-540 (2005)
Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein. We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2ad8208a8820a9d0638198f50fcf27
https://doi.org/10.1016/j.nbd.2005.04.009
https://doi.org/10.1016/j.nbd.2005.04.009
Autor:
Michael Bahr, Andreas Striebinger, Ulrich Ebert, John E. Harlan, Eve H. Barlow, Patrick Keller, Heinz Hillen, Carsten Krantz, Volker Nimmrich, Bodo Janson, Stefan Barghorn, Robert S. Bitner, Martin Schmidt
Publikováno v:
Journal of Neurochemistry. 95:834-847
Amyloid b-peptide (Ab)1)42 oligomers have recently been discussed as intermediate toxic species in Alzheimer’s disease (AD) pathology. Here we describe a new and highly stable Ab1)42 oligomer species which can easily be prepared in vitro and is pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f5af21a80973eb18cd6911a3aecdef
https://doi.org/10.1111/j.1471-4159.2005.03407.x
https://doi.org/10.1111/j.1471-4159.2005.03407.x
Publikováno v:
Epilepsy Research. 62:135-156
Most patients with temporal lobe epilepsy (TLE), the most common type of epilepsy, show pronounced loss of neurons in limbic brain regions, including the hippocampus, amygdala, and parahippocampal regions. Hippocampal damage in patients with TLE is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622e81ef598a68ce3e41be4d9ef41d28
https://doi.org/10.1016/j.eplepsyres.2004.08.008
https://doi.org/10.1016/j.eplepsyres.2004.08.008
Autor:
Wolfgang Löscher, Jessie Gu, Michael Elashoff, Henrik Klitgaard, Berkley A. Lynch, Dina Anderson, Sun Lu, Heidrun Potschka, Ulrich Ebert
Publikováno v:
European Journal of Neuroscience. 19:334-345
Gene expression profiling by microarrays is a powerful tool for identification of genes that may encode key proteins involved in molecular mechanisms underlying epileptogenesis. Using the Affymetrix oligonucleotide microarray, we have surveyed the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb1f3d653732a5a943253f900496158
https://doi.org/10.1111/j.0953-816x.2003.03106.x
https://doi.org/10.1111/j.0953-816x.2003.03106.x