Zobrazeno 1 - 10
of 296
pro vyhledávání: '"Ulrich, Brinkmann"'
Autor:
Vedran Vasic, Steffen Dickopf, Nadine Spranger, Rose-Sophie Rosenberger, Michaela Fischer, Klaus Mayer, Vincent Larraillet, Jack A. Bates, Verena Maier, Tatjana Sela, Bianca Nussbaum, Harald Duerr, Stefan Dengl, Ulrich Brinkmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The generation of antibody-drug conjugates with optimal functionality depends on many parameters. These include binder epitope, antibody format, linker composition, conjugation site(s), drug-to-antibody ratio, and conjugation method. The pro
Externí odkaz:
https://doaj.org/article/036b3d31ae614275ab825efcefdb518e
Autor:
Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer, Ulrich Brinkmann
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-cytokine fusions targeted against tumor-associated antigens (TAAs) are promising cancer immunotherapy agents, with many such molecules currently undergoing clinical trials. However, due to the limited number of tumor-specific targets
Externí odkaz:
https://doaj.org/article/ee329adfb2144539ad1e235379420104
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 470 (2024)
The Dph1•Dph2 heterodimer from yeast is a radical SAM (RS) enzyme that generates the 3-amino-3-carboxy-propyl (ACP) precursor for diphthamide, a clinically relevant modification on eukaryotic elongation factor 2 (eEF2). ACP formation requires SAM c
Externí odkaz:
https://doaj.org/article/4885663f9ef24ec5b6416dff957b3c23
Autor:
Koray Ütkür, Klaus Mayer, Maliha Khan, Thirishika Manivannan, Raffael Schaffrath, Ulrich Brinkmann
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/1caf3846ec4d42b2846ff9374c73dc38
Autor:
Meike Arend, Koray Ütkür, Harmen Hawer, Klaus Mayer, Namit Ranjan, Lorenz Adrian, Ulrich Brinkmann, Raffael Schaffrath
Publikováno v:
Microbial Cell, Vol 10, Iss 9, Pp 195-203 (2022)
In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the t
Externí odkaz:
https://doaj.org/article/cbab6fc1de5a40b2b53aba41197cf186
Autor:
Hongliang Zhang, Julia Quintana, Koray Ütkür, Lorenz Adrian, Harmen Hawer, Klaus Mayer, Xiaodi Gong, Leonardo Castanedo, Anna Schulten, Nadežda Janina, Marcus Peters, Markus Wirtz, Ulrich Brinkmann, Raffael Schaffrath, Ute Krämer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Diphthamide is a post-translationally modified histidine residue present in animal and yeast TRANSLATION ELONGATION FACTOR2. Here the authors show that diphthamide modification of eEF2 is conserved in Arabidopsis thaliana and contributes to translati
Externí odkaz:
https://doaj.org/article/6f327076063f4dbf96b4af8e17a36d64
Autor:
Koray Ütkür, Sarina Schmidt, Klaus Mayer, Roland Klassen, Ulrich Brinkmann, Raffael Schaffrath
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1655 (2023)
In eukaryotes, the Dph1•Dph2 dimer is a non-canonical radical SAM enzyme. Using iron-sulfur (FeS) clusters, it cleaves the cosubstrate S-adenosyl-methionine (SAM) to form a 3-amino-3-carboxy-propyl (ACP) radical for the synthesis of diphthamide. Th
Externí odkaz:
https://doaj.org/article/ac1e3fe6356047c1ac44fece660b5614
Autor:
Stefan Dengl, Klaus Mayer, Felix Bormann, Harald Duerr, Eike Hoffmann, Bianca Nussbaum, Michael Tischler, Martina Wagner, Andreas Kuglstatter, Lea Leibrock, Can Buldun, Guy Georges, Ulrich Brinkmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Bispecific antibodies have been generated in many different formats and it is becoming clear that rational design alone cannot create optimal functionalities. Here the authors introduce the high throughput methodology, Format Chain Exchange (FORCE),
Externí odkaz:
https://doaj.org/article/2e93ad508e924c6e932a762afd54dddb
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1221-1227 (2020)
Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality. This
Externí odkaz:
https://doaj.org/article/6d23cfca0fd1457390186925d84637a4
Autor:
Guy J. Georges, Stefan Dengl, Alexander Bujotzek, Friederike Hesse, Jens A.A. Fischer, Achim Gärtner, Jörg Benz, Matthias E. Lauer, Philippe Ringler, Henning Stahlberg, Friederike Plath, Ulrich Brinkmann, Sabine Imhof-Jung
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1210-1220 (2020)
The careful design of the antibody architecture is becoming more and more important, especially when the purpose is agonism. We present the design of a novel antibody format that is able to promote receptor dimerization and induce signal transduction
Externí odkaz:
https://doaj.org/article/e63a7374d4ac4858b91e6da04a61a06c