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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Autor: Hautakangas, H., Winsvold, B.S., Ruotsalainen, S.E., Bjornsdottir, G., Harder, A.V.E., Kogelman, L.J.A., Thomas, L.F., Noordam, R., Benner, C., Gormley, P., Artto, V., Banasik, K., Bjornsdottir, A., Boomsma, D.I., Brumpton, B., Burgdorf, K.S., Buring, J.E., Chalmer, M.A., Boer, I. de, Dichgans, M., Erikstrup, C., Farkkila, M., Garbrielsen, M.E., Ghanbari, M., Hagen, K., Happola, P., Hottenga, J.J., Hrafnsdottir, M.G., Hveem, K., Johnsen, M.B., Kahonen, M., Kristoffersen, E.S., Kurth, T., Lehtimaki, T., Lighart, L., Magnusson, S.H., Malik, R., Pedersen, O.B., Pelzer, N., Penninx, B.W.J.H., Ran, C., Ridker, P.M., Rosendaal, F.R., Sigurdardottir, G.R., Skogholt, A.H., Sveinsson, O.A., Thorgeirsson, T.E., Ullum, H., Vijfhuizen, L.S., Widen, E., Dijk, K.W. van, Aromaa, A., Belin, A.C., Freilinger, T., Ikram, M.A., Jarvelin, M.R., Raitakari, O.T., Terwindt, G.M., Kallela, M., Wessman, M., Olesen, J., Chasman, D.I., Nyholt, D.R., Stefansson, H., Stefansson, K., Maagdenberg, A.M.J.M. van den, Hansen, T.F., Ripatti, S., Zwart, J.A., Palotie, A., Pirinen, M., Int Headache Genetics Consortium, HUNT All-in Headache, Danish Blood Donor Study Genomic C

Publikováno v: Nature genetics, 54(2), 152-160. Nature Publishing Group
Nature Genetics
International Headache Genetics Consortium, HUNT All-in Headache & Danish Blood Donor Study Genomic Cohort 2022, ' Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles ', Nature Genetics, vol. 54, no. 2, pp. 152-160 . https://doi.org/10.1038/s41588-021-00990-0
Nature Genetics, 54, 152-160. NATURE PORTFOLIO
Hautakangas, H, Winsvold, B S, Ruotsalainen, S E, Bjornsdottir, G, Harder, A V E, Kogelman, L J A, Thomas, L F, Noordam, R, Benner, C, Gormley, P, Artto, V, Banasik, K, Bjornsdottir, A, Boomsma, D I, Brumpton, B M, Burgdorf, K S, Buring, J E, Chalmer, M A, de Boer, I, Dichgans, M, Erikstrup, C, Farkkila, M, Garbrielsen, M E, Ghanbari, M, Hagen, K, Happola, P, Hottenga, J-J, Hrafnsdottir, M G, Hveem, K, Johnsen, M B, Kahonen, M, Kristoffersen, E S, Kurth, T, Lehtimaki, T, Lighart, L, Magnusson, S H, Malik, R, Pedersen, O B, Pelzer, N, Penninx, B W J H, Ran, C, Ridker, P M, Rosendaal, F R, Sigurdardottir, G R, Skogholt, A H, Sveinsson, O A, Thorgeirsson, T E, Ullum, H, Vijfhuizen, L S, Widen, E, van Dijk, K W, Aromaa, A, Belin, A C, Freilinger, T, Ikram, M A, Jarvelin, M-R, Raitakari, O T, Terwindt, G M, Kallela, M, Wessman, M, Olesen, J, Chasman, D I, Nyholt, D R, Stefansson, H, Stefansson, K, van den Maagdenberg, A M J M, Hansen, T F, Ripatti, S, Zwart, J-A, Palotie, A & Pirinen, M 2022, ' Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles ', Nature Genetics, vol. 54, pp. 152-160 . https://doi.org/10.1038/s41588-021-00990-0
Hautakangas, H, Winsvold, B S, Ruotsalainen, S E, Bjornsdottir, G, Harder, A V E, Kogelman, L J A, Thomas, L F, Noordam, R, Benner, C, Gormley, P, Artto, V, Banasik, K, Bjornsdottir, A, Boomsma, D I, Brumpton, B M, Burgdorf, K S, Buring, J E, Chalmer, M A, de Boer, I, Dichgans, M, Erikstrup, C, Färkkilä, M, Garbrielsen, M E, Ghanbari, M, Hagen, K, Häppölä, P, Hottenga, J J, Hrafnsdottir, M G, Hveem, K, Johnsen, M B, Kähönen, M, Kristoffersen, E S, Kurth, T, Lehtimäki, T, Lighart, L, Magnusson, S H, Malik, R, Pedersen, O B, Pelzer, N, Penninx, B W J H, Ran, C, Ridker, P M, Rosendaal, F R, Sigurdardottir, G R, Skogholt, A H, Sveinsson, O A, Thorgeirsson, T E, Ullum, H, Vijfhuizen, L S, Widen, E, van Dijk, K W, International Headache Genetics Consortium, HUNT All-in Headache, Danish Blood Donor Study Genomic Cohort, Aromaa, A, Belin, A C, Freilinger, T, Ikram, M A, Järvelin, M-R, Raitakari, O T, Terwindt, G M, Kallela, M, Wessman, M, Olesen, J, Chasman, D I, Nyholt, D R, Stefansson, H, Stefansson, K, van den Maagdenberg, A M J M, Hansen, T F, Ripatti, S, Zwart, J-A, Palotie, A & Pirinen, M 2022, ' Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles ', Nature Genetics, vol. 54, no. 2, pp. 152-160 . https://doi.org/10.1038/s41588-021-00990-0
Nature Genetics, 54(2), 152-160. Nature Publishing Group
Hautakangas, H, Winsvold, B S, Boomsma, D I, Hottenga, J-J, Ligthart, L, Penninx, B W J H, Palotie, A, Pirinen, M & International Headache Genetics Consortium 2022, ' Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles ', Nature genetics, vol. 54, no. 2, pp. 152-160 . https://doi.org/10.1038/s41588-021-00990-0

Genome-wide association analyses identify 123 susceptibility loci for migraine and implicate neurovascular mechanisms in its pathophysiology. Subtype analyses highlight risk loci specific for migraine with or without aura in addition to shared risk v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271e89f31a913a67875ee7088a9a1e7c
https://research.vu.nl/en/publications/dad00511-8fd1-468a-a806-7f8306e18447

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