Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Ullrich Keller"'
Autor:
Caroline J Voskens, Simone M Goldinger, Carmen Loquai, Caroline Robert, Katharina C Kaehler, Carola Berking, Tanja Bergmann, Clemens L Bockmeyer, Thomas Eigentler, Michael Fluck, Claus Garbe, Ralf Gutzmer, Stephan Grabbe, Axel Hauschild, Rüdiger Hein, Gheorghe Hundorfean, Armin Justich, Ullrich Keller, Christina Klein, Christine Mateus, Peter Mohr, Sylvie Paetzold, Imke Satzger, Dirk Schadendorf, Marc Schlaeppi, Gerold Schuler, Beatrice Schuler-Thurner, Uwe Trefzer, Jens Ulrich, Julia Vaubel, Roger von Moos, Patrik Weder, Tabea Wilhelm, Daniela Göppner, Reinhard Dummer, Lucie M Heinzerling
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53745 (2013)
Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients. Treatment algorithms for the management of common ipilimum
Externí odkaz:
https://doaj.org/article/1e9dff99dd604582ac2c2c7a3f9fad75
Autor:
Ria Spallek, Carmen Paulmann, Oleksandra Karpiuk, Jana Zecha, Susan Klaeger, Isabell Schaeffer, Rupert Öllinger, Thomas Engleitner, Jan Krönke, Matthias Wirth, Ullrich Keller, Roland Rad, Bernahrd Kuster, Florian Bassermann
Publikováno v:
Cancer Research. 82:2298-2298
Multiple myeloma (MM) is the second most common hematological malignancy and remains incurable, thus demanding for new therapeutic targets. While the pathophysiology of MM is poorly understood, the substantial responsiveness of MM patients to proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c9d6b5c0367654ad774dce2a7bb57a0
https://doi.org/10.1158/1538-7445.am2022-2298
https://doi.org/10.1158/1538-7445.am2022-2298
Publikováno v:
Journal of Basic Microbiology. 59:148-157
Actinomycin peptide synthetase genes constitute two oppositely oriented transcriptional units, acmADR, and acmBC, separated by a non-coding intergenic region. Gene constructs of the intergenic region together with its adjoining gene acmA or acmB from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77ea4361de0efdf284558d698c70dff
https://doi.org/10.1002/jobm.201800244
https://doi.org/10.1002/jobm.201800244
Autor:
Manuel Lang, Ullrich Keller, Jörn Kalinowski, Christian Rückert, Siamak Semsary, Ivana Crnovcic
Publikováno v:
Advances and Applications in Bioinformatics and Chemistry. 10:29-46
Sequencing the actinomycin (acm) biosynthetic gene cluster of Streptomyces antibioticus IMRU 3720, which produces actinomycin X (Acm X), revealed 20 genes organized into a highly similar framework as in the bi-armed acm C biosynthetic gene cluster of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf020d149d5c0d29b103c5224c4c223
https://doi.org/10.2147/aabc.s117707
https://doi.org/10.2147/aabc.s117707
Publikováno v:
Biologie in unserer Zeit. 46:236-243
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686edc64cbfd938df45afae55ca7bf60
https://doi.org/10.1002/biuz.201610598
https://doi.org/10.1002/biuz.201610598
Autor:
Hildgund Schrempf, Ullrich Keller
Publikováno v:
BIOspektrum. 22:22-25
Streptomycetes are differentiated members of actinobacteria with huge abundance in soils, rhizosphere, and marine sediments. In addition to main roles in a free-living style, they are relevant in multiple interactions and specialized symbioses. Their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d824a4d9f17281c1aa29ab9f1bce1183
https://doi.org/10.1007/s12268-016-0651-x
https://doi.org/10.1007/s12268-016-0651-x
Publikováno v:
Chembiochem : a European journal of chemical biology. 19(7)
X-type actinomycins (Acms) contain 4-hydroxyproline (Acm X0 ) or 4-oxoproline (Acm X2 ) in their β-pentapeptide lactone rings, whereas their α ring contains proline. We demonstrate that these Acms are formed through asymmetric condensation of Acm h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e386ccdc45c93df3963ef29f72f425
https://pubmed.ncbi.nlm.nih.gov/29327817
https://pubmed.ncbi.nlm.nih.gov/29327817
Publikováno v:
Journal of Mass Spectrometry. 49:210-222
An extensive study of actinomycins was performed using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS). Actinomycins represent a well-known family of peptidolactone chromopeptides with potent cytostatic and antibiotic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bf808b20e8e55fd5084033de2d3072
https://doi.org/10.1002/jms.3329
https://doi.org/10.1002/jms.3329
Autor:
Ullrich Keller, Ingo Ortel
Publikováno v:
Journal of Biological Chemistry. 284:6650-6660
The ergot fungus Claviceps purpurea produces both ergopeptines and simple d-lysergic acid alkylamides. In the ergopeptines, such as ergotamine, d-lysergic acid is linked to a bicyclic tripeptide in amide-like fashion, whereas in the d-lysergylalkanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d513a75d2eb58a7d8cb2f492f96dbf
https://doi.org/10.1074/jbc.m807168200
https://doi.org/10.1074/jbc.m807168200
Publikováno v:
ChemBioChem. 7:645-652
Clavines and D-lysergic acid-derived alkaloid amides and alkaloid peptides are two different families of compounds that have the indole-derived tetracyclic metergoline ring system in common. Previous work has shown that D-lysergic acid is biosyntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58454f31fdbc6b079e600fe9f2a55e6c
https://doi.org/10.1002/cbic.200500487
https://doi.org/10.1002/cbic.200500487