KDM5B predicts temozolomide-resistant subclones in glioblastoma.

Autor: Ullrich V; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Ertmer S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Baginska A; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany., Dorsch M; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany., Gull HH; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany., Cima I; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Berger P; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Dobersalske C; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Langer S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Meyer L; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Dujardin P; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany., Kebir S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany.; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, 45147 Essen, Germany., Glas M; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany.; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, 45147 Essen, Germany., Blau T; Department of Neuropathology, University Hospital Essen, 45147 Essen, Germany., Keyvani K; Department of Neuropathology, University Hospital Essen, 45147 Essen, Germany., Rauschenbach L; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany., Sure U; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45147 Essen, Germany.; Center for Translational Neuroscience and Behavioral Science (C-TNBS), University of Duisburg-Essen, 45147 Essen, Germany., Roesch A; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Dermatology, University Hospital Essen, 45147 Essen, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, 45141 Essen, Germany., Grüner BM; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, 45141 Essen, Germany., Scheffler B; DKFZ-Division Translational Neurooncology at the WTZ, DKTK partner site, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, 45141 Essen, Germany.

Publikováno v: IScience [iScience] 2023 Dec 03; Vol. 27 (1), pp. 108596. Date of Electronic Publication: 2023 Dec 03 (Print Publication: 2024).

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities.

Autor: Kuhn CK; Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany., Meister J; Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany.; Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Kreft S; Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium Partner Site Essen/Düsseldorf, Essen, Germany., Stiller M; Institute of Pathology, University of Leipzig Medical Center, Leipzig, Germany., Puppel SH; Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany., Zaremba A; Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium Partner Site Essen/Düsseldorf, Essen, Germany., Scheffler B; DKFZ-Division Translational Neurooncology at the West German Cancer Center, University Hospital Essen/University of Duisburg-Essen, Essen, Germany., Ullrich V; DKFZ-Division Translational Neurooncology at the West German Cancer Center, University Hospital Essen/University of Duisburg-Essen, Essen, Germany., Schöneberg T; Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany.; School of Medicine, University of Global Health Equity, Kigali, Rwanda., Schadendorf D; Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium Partner Site Essen/Düsseldorf, Essen, Germany., Horn S; Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany.; Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium Partner Site Essen/Düsseldorf, Essen, Germany.

Publikováno v: PloS one [PLoS One] 2023 Jul 07; Vol. 18 (7), pp. e0281487. Date of Electronic Publication: 2023 Jul 07 (Print Publication: 2023).

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma.

Autor: Kebir S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Ullrich V; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Berger P; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Dobersalske C; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Langer S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Rauschenbach L; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Trageser D; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany.; LIFE & BRAIN GmbH, Cellomics Unit, Bonn, Germany., Till A; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany., Lorbeer FK; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany., Wieland A; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany., Wilhelm-Buchstab T; Department of Radiology, University of Bonn Medical Center, Bonn, Germany., Ahmad A; Bonn-Aachen International Center for IT (B-IT), University of Bonn, Bonn, Germany., Fröhlich H; Bonn-Aachen International Center for IT (B-IT), University of Bonn, Bonn, Germany.; Department of Bioinformatics, Fraunhofer SCAI, Schloss Birlinghoven, Sankt Augustin, Germany., Cima I; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Prasad S; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Matschke J; Institute of Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany., Jendrossek V; Institute of Cell Biology (Cancer Research), University Hospital Essen, Essen, Germany., Remke M; German Cancer Consortium (DKTK).; Pediatric Neuro-Oncogenomics, University Hospital Düsseldorf, Düsseldorf, Germany., Grüner BM; German Cancer Consortium (DKTK).; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Roesch A; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Department of Dermatology, University Hospital Essen, Essen, Germany., Siveke JT; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Herold-Mende C; Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany., Blau T; Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany., Keyvani K; Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany., van Landeghem FKH; Institute of Neuropathology, University of Bonn, Bonn, Germany., Pietsch T; Institute of Neuropathology, University of Bonn, Bonn, Germany., Felsberg J; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany., Reifenberger G; German Cancer Consortium (DKTK).; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany., Weller M; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland., Sure U; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany., Brüstle O; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany.; LIFE & BRAIN GmbH, Cellomics Unit, Bonn, Germany., Simon M; Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.; Department of Neurosurgery, Bethel Clinic, University of Bielefeld Medical Center, OWL, Bielefeld, Germany., Glas M; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, Essen, Germany.; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany., Scheffler B; DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK).; West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center of Medical Biotechnology (ZMB), University Duisburg-Essen, Essen, Germany.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jan 17; Vol. 29 (2), pp. 488-500.

Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols.

Autor: Schildknecht S; Albstadt-Sigmaringen University, Faculty of Life Sciences, 72488, Sigmaringen, Germany. Electronic address: schildknecht@hs-albsig.de., von Kriegsheim A; Institute of Genetics and Cancer, University of Edinburgh, UK., Vujacic-Mirski K; Center for Cardiology, Department of Cardiology 1, Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg University, 55131, Mainz, Germany., Di Lisa F; Department of Biomedical Sciences, University of Padova, Padova, Italy., Ullrich V; Department of Biology, University of Konstanz, Germany., Daiber A; Center for Cardiology, Department of Cardiology 1, Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg University, 55131, Mainz, Germany; Partner Site Rhine-Main, German Center for Cardiovascular Research (DZHK), Langenbeckstr. 1, 55131, Mainz, Germany. Electronic address: daiber@uni-mainz.de.

Publikováno v: Redox biology [Redox Biol] 2022 Oct; Vol. 56, pp. 102439. Date of Electronic Publication: 2022 Aug 14.