Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ullas V. Chembazhi"'
Autor:
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, Eric L. Van Nostrand, Sushant Bangru, Grace Guzman, Gene W. Yeo, Kannanganattu V. Prasanth, Sayeepriyadarshini Anakk, Carolyn L. Cummins, Auinash Kalsotra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hep
Externí odkaz:
https://doaj.org/article/ee830a8f79654480908b12970aefaf07
Autor:
Jianhao Peng, Guillermo Serrano, Ian M. Traniello, Maria E. Calleja-Cervantes, Ullas V. Chembazhi, Sushant Bangru, Teresa Ezponda, Juan Roberto Rodriguez-Madoz, Auinash Kalsotra, Felipe Prosper, Idoia Ochoa, Mikel Hernaez
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
SimiC, a single-cell gene regulatory inference framework is presented that can infer multiple gene regulatory networks across related cell phenotypes, unraveling complex regulatory dynamics.
Externí odkaz:
https://doaj.org/article/fa439cbcedcc415a9f8c9bea20c8ce19
Autor:
Surabhi Sonam, Sushant Bangru, Kimberly J. Perry, Ullas V. Chembazhi, Auinash Kalsotra, Jonathan J. Henry
Publikováno v:
Dev Biol
Corneal Epithelial Stem Cells (CESCs) and their proliferative progeny, the Transit Amplifying Cells (TACs), are responsible for homeostasis and maintaining corneal transparency. Owing to our limited knowledge of cell fates and gene activity within th
Autor:
Tianyi Chen, Jeongeun Hyun, Ali Ahmadi, Hidekazu Tsukamoto, Zhaoli Sun, Kuo Du, Ullas V. Chembazhi, Anna Mae Diehl, Ivan Rusyn, Sushant Bangru, Auinash Kalsotra
Publikováno v:
J Clin Invest
Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature liver cells, why this occurs and how it causes death are unclear. Here
Autor:
Wesley Tung, Jing Yang, Ullas V. Chembazhi, Sushant Bangru, Auinash Kalsotra, Wenyan Mei, Ka Lam Nguyen, Aryan Lalwani, Danielle Yee, Kristy Chin
Properly controlled intestinal epithelial cell regeneration is not only vital for protection against insults from environmental hazards but also crucial for preventing intestinal cancer. Intestinal stem cells located in the crypt region provide the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da68ae06319b11fff8bfba097fe6a91
https://doi.org/10.1101/2021.11.03.466345
https://doi.org/10.1101/2021.11.03.466345
Publikováno v:
Circulation Research. 129
Myotonic Dystrophy type 1 (DM1), the most prevalent form of adult-onset muscular dystrophy, is caused by CTG trinucleotide repeat expansion in the 3’-UTR of the DMPK gene. Heart dysfunctions occur in nearly 80% of DM1 patients, and cardiac arrhythm
Autor:
Sayeepriyadarshini Anakk, Kannanganattu V. Prasanth, Gene W. Yeo, Ullas V. Chembazhi, Carolyn L. Cummins, Steven M. Blue, Michael F. Saikali, Qinyu Hao, Van Nostrand El, Bhoomika Mathur, Brian A. Yee, Waqar Arif, Sushant Bangru, Auinash Kalsotra
Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4ad0652a65921864401be82090dd34
https://doi.org/10.1101/2021.07.10.451875
https://doi.org/10.1101/2021.07.10.451875
Autor:
Long M. Luu, Lauren D. Hagler, Steven C. Zimmerman, Auinash Kalsotra, Julio F. Serrano, Shaohong Peng, Kevin Yum, Ju Yeon Lee, Ullas V. Chembazhi, Yugang Bai, H.Y. Edwin Chan
Publikováno v:
Proceedings of the National Academy of Sciences. 116:8709-8714
Developing highly active, multivalent ligands as therapeutic agents is challenging because of delivery issues, limited cell permeability, and toxicity. Here, we report intrinsically cell-penetrating multivalent ligands that target the trinucleotide r
Myotonic Dystrophy type 1 (DM1) is multi-systemic muscular dystrophy, affecting 1 in 3000 people, characterized by muscle wasting, myotonia, cardiac and gastrointestinal abnormalities and cognitive impairment, among other symptoms. DM1 is caused by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6494dd835dd38e543686a36945c414
https://doi.org/10.1101/2021.04.06.438688
https://doi.org/10.1101/2021.04.06.438688
Publikováno v:
Circulation Research. 127
Myotonic Dystrophy type 1 (DM1), the most prevalent form of adult onset muscular dystrophy, is caused by CTG trinucleotide repeat expansion in the 3’-UTR of DMPK gene. Over 80% of DM1 patients exhibit heart dysfunctions, which are the second leadin