Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ulla Seibel"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9739 (2021)
G protein activation represents an early key event in the complex GPCR signal transduction process and is usually studied by label-dependent methods targeting specific molecular events. However, the constrained environment of such “invasive” tech
Externí odkaz:
https://doaj.org/article/c15deab3006143ce9f22ff5a079cca50
Autor:
Carina Höring, Ulla Seibel, Katharina Tropmann, Lukas Grätz, Denise Mönnich, Sebastian Pitzl, Günther Bernhardt, Steffen Pockes, Andrea Strasser
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8440 (2020)
In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of GPCR-G protein interactions and G protein
Externí odkaz:
https://doaj.org/article/b106ab011dc5460da9eb1dce75d2e44c
Autor:
Lukas Grätz, Jan Möller, Laura J Humphrys, Steffen Pockes, Ali Işbilir, Niklas Rosier, Martin J. Lohse, Hannes Schihada, Martin Nagl, Ulla Seibel
Publikováno v:
Journal of Medicinal Chemistry. 64:11695-11708
The histamine H3 receptor (H3R) is considered an attractive drug target for various neurological diseases. We here report the synthesis of UR-NR266, a novel fluorescent H3R ligand. Broad pharmacological characterization revealed UR-NR266 as a sub-nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f12c3455be4acdb437e98401731849
https://doi.org/10.1021/acs.jmedchem.1c01089
https://doi.org/10.1021/acs.jmedchem.1c01089
Autor:
Ulla Seibel, Günther Bernhardt, David Wifling, Timo Littmann, Edith Bartole, Lukas Grätz, Armin Buschauer
Publikováno v:
Journal of Medicinal Chemistry. 63:5297-5311
Comprehensively characterized fluorescent probes for the histamine H3 receptor (H3R) and especially for the H4R orthologs [e.g., human (h) and mouse (m)] are highly needed as versatile complementar...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2390c7cef4470dee1ff2c510e47fd6f
https://doi.org/10.1021/acs.jmedchem.0c00160
https://doi.org/10.1021/acs.jmedchem.0c00160
Publikováno v:
Bioorganicmedicinal chemistry letters. 52
So far, only little is known about the internalization process of the histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::667cc93079f1e92fb4a578c011e2b65e
https://pubmed.ncbi.nlm.nih.gov/34600035
https://pubmed.ncbi.nlm.nih.gov/34600035
Autor:
Niklas, Rosier, Lukas, Grätz, Hannes, Schihada, Jan, Möller, Ali, Işbilir, Laura J, Humphrys, Martin, Nagl, Ulla, Seibel, Martin J, Lohse, Steffen, Pockes
Publikováno v:
Journal of medicinal chemistry. 64(15)
The histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70d784c26ad8231fa531b420cc9e178e
https://pubmed.ncbi.nlm.nih.gov/34309390
https://pubmed.ncbi.nlm.nih.gov/34309390
Autor:
Katarzyna, Szczepańska, Steffen, Pockes, Sabina, Podlewska, Carina, Höring, Kamil, Mika, Gniewomir, Latacz, Marek, Bednarski, Agata, Siwek, Tadeusz, Karcz, Martin, Nagl, Merlin, Bresinsky, Denise, Mönnich, Ulla, Seibel, Kamil J, Kuder, Magdalena, Kotańska, Holger, Stark, Sigurd, Elz, Katarzyna, Kieć-Kononowicz
Publikováno v:
European journal of medicinal chemistry. 213
A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved to be potent histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::714d1f27b2325a285b137f0d7134bbec
https://pubmed.ncbi.nlm.nih.gov/33261900
https://pubmed.ncbi.nlm.nih.gov/33261900
Autor:
Edith, Bartole, Lukas, Grätz, Timo, Littmann, David, Wifling, Ulla, Seibel, Armin, Buschauer, Günther, Bernhardt
Publikováno v:
Journal of medicinal chemistry. 63(10)
Comprehensively characterized fluorescent probes for the histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aef4c8baf3caf7ab20f1031ad2225eb4
https://pubmed.ncbi.nlm.nih.gov/32420741
https://pubmed.ncbi.nlm.nih.gov/32420741
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 52:128388
So far, only little is known about the internalization process of the histamine H2 receptor (H2R). One promising approach to study such dynamic processes is the use of agonistic fluorescent ligands. Therefore, a series of carbamoylguanidine-type H2R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8874085ce98cadb9aad77c58588e1b7d
https://doi.org/10.1016/j.bmcl.2021.128388
https://doi.org/10.1016/j.bmcl.2021.128388
Autor:
Maria Kaleta, Kamil Kuder, Holger Stark, Armin Buschauer, Dorota Łażewska, Monika Głuch-Lutwin, Ulla Seibel, Małgorzata Więcek, Katarzyna Kieć-Kononowicz, Agata Siwek, Szczepan Mogilski, Stefanie Hagenow, Barbara Filipek
This study focuses on the design, synthesis, molecular modeling and biological evaluation of a novel group of alkyl-1,3,5-triazinyl-methylpiperazines. New compounds were synthesized and their affinities for human histamine H4 receptor (hH4R) were eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626aca616cc259b95af96e8c40ea0c19
https://ruj.uj.edu.pl/xmlui/handle/item/145731
https://ruj.uj.edu.pl/xmlui/handle/item/145731
