Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Ulla Pirvola"'
Autor:
Jukka Ylikoski, Marika Markkanen, Ulla Pirvola, Jarmo Antero Lehtimäki, Matti Ylikoski, Zou Jing, Saku T. Sinkkonen, Antti Mäkitie
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
IntroductionTinnitus can become a strong stressor for some individuals, leading to imbalance of the autonomous nervous system with reduction of parasympathetic activity. It can manifest itself as sleep disturbances, anxiety and even depression. This
Externí odkaz:
https://doaj.org/article/cc2ba29dcd714763a9bbccbcae8ecfee
Publikováno v:
Biology Open, Vol 4, Iss 4, Pp 516-526 (2015)
Hair cells of the organ of Corti (OC) of the cochlea exhibit distinct planar polarity, both at the tissue and cellular level. Planar polarity at tissue level is manifested as uniform orientation of the hair cell stereociliary bundles. Hair cell intri
Externí odkaz:
https://doaj.org/article/ae1533763def45c8af84a6d55201e766
Autor:
Kuu, Ikäheimo, Anni, Herranen, Vilma, Iivanainen, Tuuli, Lankinen, Antti A, Aarnisalo, Ville, Sivonen, Kashyap A, Patel, Korcan, Demir, Mart, Saarma, Maria, Lindahl, Ulla, Pirvola
Publikováno v:
Life Science Alliance
The authors show in the mouse how the auditory hair cell structural maintenance is perturbed by the inactivation of Manf and the concomitant ER stress, causing early-onset, progressive hearing loss.
Failure in the structural maintenance of the h
Failure in the structural maintenance of the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a0df97a54dd8d8ac38229f10cc9791f
https://pubmed.ncbi.nlm.nih.gov/34815294
https://pubmed.ncbi.nlm.nih.gov/34815294
Autor:
Mart Saarma, Kuu Ikäheimo, Anni Herranen, Tuuli Lankinen, Bernd Fritzsch, Emmi Pakarinen, Ulla Pirvola, Maria Lindahl
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 2, Pp 1-12 (2020)
Cell Death and Disease, Vol 11, Iss 2, Pp 1-12 (2020)
The non-conventional neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident protein that promotes ER homeostasis. MANF has a cytoprotective function, shown in the central nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1518ef830c09a892ebf580318e90c6
https://doi.org/10.1038/s41419-020-2286-6
https://doi.org/10.1038/s41419-020-2286-6
Publikováno v:
Journal of the Association for Research in Otolaryngology. 19:637-652
Various stressors, such as loud sounds and the effects of aging, impair the function and viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological changes in the cochlear non-sensory cells as well. We have here stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2c0d14591318b800fc336d171ec600
https://doi.org/10.1007/s10162-018-00691-2
https://doi.org/10.1007/s10162-018-00691-2
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27360 (2011)
Sensory hair cells and supporting cells of the mammalian inner ear are quiescent cells, which do not regenerate. In contrast, non-mammalian supporting cells have the ability to re-enter the cell cycle and produce replacement hair cells. Earlier studi
Externí odkaz:
https://doaj.org/article/e8dc6b9312754adc93620accad1fe25b
Autor:
Matti Ylikoski, Antti Mäkitie, Annett Szibor, Ulla Pirvola, Jarmo Lehtimäki, Antti A. Aarnisalo, Petteri Hyvärinen, Jukka Ylikoski
Publikováno v:
Acta oto-laryngologica. 138(1)
Conclusion: Music-induced acute acoustic trauma is not inevitably linked to hearing dysfunction as validated by conventional pure tone audiometry. Tinnitus is often in combination with hyperacusis. Our results point at 'silent hearing loss' as the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0997492c9887fcc0791a47e86e69dcf3
https://pubmed.ncbi.nlm.nih.gov/28859531
https://pubmed.ncbi.nlm.nih.gov/28859531
Autor:
Tommi, Anttonen, Ilya, Belevich, Maarja, Laos, Anni, Herranen, Eija, Jokitalo, Cord, Brakebusch, Ulla, Pirvola
Publikováno v:
eNeuro
Wound healing in the inner ear sensory epithelia is performed by the apical domains of supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become exceptionally thick during maturation. The functional significance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7413978efae0c74de8af771f4a26b5d7
https://pubmed.ncbi.nlm.nih.gov/28929130
https://pubmed.ncbi.nlm.nih.gov/28929130
Publikováno v:
Scientific Reports
p53 is a key component of a signaling network that protects cells against various stresses. As excess p53 is detrimental to cells, its levels are tightly controlled by several mechanisms. The E3 ubiquitin ligase Mdm2 is a major negative regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93a6298db3d8c2a708c45faefbf38d1
Autor:
Matti Ylikoski, Antti A. Aarnisalo, Ulla Pirvola, Jarmo Lehtimäki, Petteri Hyvärinen, Antti Mäkitie, Jukka Ylikoski
Publikováno v:
Acta oto-laryngologica. 137(4)
Conclusion: Transcutaneous vagal nerve stimulation (tVNS) might offer a targeted, patient-friendly, and low-cost therapeutic tool for tinnitus patients with sympathovagal imbalance. Objectives: Conventionally, VNS has been performed to treat severe e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445ce1e116fb95d080a8bc31a7c640ae
https://pubmed.ncbi.nlm.nih.gov/28084177
https://pubmed.ncbi.nlm.nih.gov/28084177