Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Ulla Hansen"'
Autor:
Patrick Stoiber, Pietro Scribani Rossi, Niranjana Pokharel, Jean-Luc Germany, Emily A. York, Scott E. Schaus, Ulla Hansen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Factor quinolinone inhibitors are promising anti-cancer compounds, initially characterized as specific inhibitors of the oncogenic transcription factor LSF (TFCP2). These compounds exert anti-proliferative activity at least in part by disrup
Externí odkaz:
https://doaj.org/article/17bb4586a609471589a4fe4bbe029ae8
Autor:
Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah, Ulla Hansen
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and colo
Externí odkaz:
https://doaj.org/article/78196f74ff6642ea90ac3be30f035d7e
Autor:
Sarah A. Yunes, Jennifer L. S. Willoughby, Julian H. Kwan, Jessica M. Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A. York, Kuan-Chung Su, Kelly George, Jagesh V. Shah, Andrew Emili, Scott E. Schaus, Ulla Hansen
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound identified, unexpectedly i
Externí odkaz:
https://doaj.org/article/6ae848c8bada4a1bafa17d2db5c202d0
Autor:
Paul Nghiem, Suzanne Topalian, Steven Fling, Nirasha Ramchurren, Candice Church, Ulla Hansen, Amalie Bentzen, Sine Hadrup
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/7321b2f7239f4bc3a0055de1acc219a5
Autor:
Saran Lotfollahzadeh, Dominic Lo, Emily A. York, Marc A. Napoleon, Wenqing Yin, Nagla Elzinad, John Le, Mengwei Zhang, Xiaosheng Yang, Austin Morrissey, Murad Elsadawi, Qing Zhao, Scott E. Schaus, Ulla Hansen, Vipul C. Chitalia
Publikováno v:
The American journal of pathology. 192(8)
Aberrant hyperactivation of Wnt signaling, driven by nuclear β-catenin in the colonic epithelium, represents the seminal event in the initiation and progression of colorectal cancer (CRC). Despite its established role in CRC tumorigenesis, clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a460f252aaba5e558857d692022673
https://pubmed.ncbi.nlm.nih.gov/35710032
https://pubmed.ncbi.nlm.nih.gov/35710032
Autor:
Jagesh V. Shah, Scott E. Schaus, Hyunjin Shin, Chandra Sekhar Pedamallu, Patrick Stoiber, Hang Gyeong Chin, Jennifer L.S. Willoughby, Mark P. Roberto, Kelly George, Ulla Hansen, Kevin Fitzgerald
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
BMC Cancer
BMC Cancer
Background The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and colorectal ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c229510c0f8416c29b009c689db12
https://doi.org/10.1186/s12885-020-07039-1
https://doi.org/10.1186/s12885-020-07039-1
Autor:
Iriny Ekladious, Yolonda L. Colson, Qing Zhao, Patrick Stoiber, Scott E. Schaus, Mark W. Grinstaff, Ulla Hansen
Publikováno v:
Biomacromolecules. 21(4)
Expansile nanoparticles (eNPs) are a promising pH-responsive polymeric drug delivery vehicle, as demonstrated in multiple intraperitoneal cancer models. However, previous delivery routes were limited to intraperitoneal injection and to a single agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084b6af769860c0d3e07c693abe2941a
https://pubmed.ncbi.nlm.nih.gov/32101401
https://pubmed.ncbi.nlm.nih.gov/32101401
Autor:
Sriharsa Pradhan, Pierre-Olivier Estève, Ulla Hansen, Hang Gyeong Chin, Cristian I. Ruse, Jiyoung Lee, Scott E. Schaus
Publikováno v:
The Journal of Biological Chemistry
Microtubules are cytoskeletal structures critical for mitosis, cell motility, and protein and organelle transport and are a validated target for anticancer drugs. However, how tubulins are regulated and recruited to support these distinct cellular pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da8c9957b57f06a6924b9c704f56dc
https://pubmed.ncbi.nlm.nih.gov/32111740
https://pubmed.ncbi.nlm.nih.gov/32111740
Autor:
Ulla Hansen, Christopher J. Noren, Hang Gyeong Chin, Sriharsa Pradhan, Colleen McClung, Cristian I. Ruse
Publikováno v:
Analytical Biochemistry. 612:113761
Tubulin polyglutamylation is a polymeric modification that extends from the carboxyl-terminus of tubulins. Molecular description of amino acids and their branching polyglutamyls is a hallmark of tubulin in microtubules. There are different chemical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104de8c4c500b109e652ac6e360d5b70
https://doi.org/10.1016/j.ab.2020.113761
https://doi.org/10.1016/j.ab.2020.113761
Autor:
Scott E. Schaus, Hang Gyeong Chin, Sriharsa Pradhan, Ulla Hansen, Pierre-Olivier Estève, Guoqiang Zhang, V.K. Chaithanya Ponnaluri
Publikováno v:
Oncotarget
// Hang Gyeong Chin 1, 2 , V.K. Chaithanya Ponnaluri 1 , Guoqiang Zhang 1 , Pierre-Olivier Esteve 1 , Scott E. Schaus 3 , Ulla Hansen 2, 4 , Sriharsa Pradhan 1 1 New England Biolabs, Inc. Ipswich, MA 01938, USA 2 MCBB Graduate Program, Boston Univers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444d2ce036fa5cd65adc61d0b536f961
https://doi.org/10.18632/oncotarget.13271
https://doi.org/10.18632/oncotarget.13271