Výsledky vyhledávání - "Ulla Bergholz"

Endogenous retrovirus induces leukemia in a xenograft mouse model for primary myelofibrosis

Autor: Thomas Stübig, Boris Fehse, Christine A. Kozak, Marion Ziegler, Vladimir S. Prassolov, Andrew J. Oler, Nicolaus Kröger, Carol Stocking, Ioanna Triviai, Ulla Bergholz

Publikováno v: Proceedings of the National Academy of Sciences. 111:8595-8600

The compound immunodeficiencies in nonobese diabetic (NOD) inbred mice homozygous for the Prkdc(scid) and Il2rg(null) alleles (NSG mice) permit engraftment of a wide-range of primary human cells, enabling sophisticated modeling of human disease. In s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a0794a377d79292faa7fa469140145
https://doi.org/10.1073/pnas.1401215111

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AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein

Autor: Miriam Rode, Carol Stocking, Hubert Serve, Ulla Bergholz, Sina Hehn, Steffen Koschmieder, Martin Stehling, Nicole Bäumer, Marcel-Philipp Henrichs, Wolfgang E. Berdel, Markus Knop, Gabriele Köhler, Martin Dugas, Carsten Müller-Tidow, Björn Steffen, Olesya Vakhrusheva, Etmar Bulk, Christian Brandts, Petra Tschanter

Publikováno v: Blood. 117:4328-4337

The most frequent translocation t(8;21) in acute myeloid leukemia (AML) generates the chimeric AML1/ETO protein, which blocks differentiation and induces self-renewal in hematopoietic progenitor cells. The underlying mechanisms mediating AML1/ETO-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb802bad897e0fc8dc7de8d5f118d97
https://doi.org/10.1182/blood-2009-09-242545

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Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate

Autor: Gunhild Sommer, Walter Fiedler, Jörg Cammenga, Carol Stocking, Ulla Bergholz, Peter Besmer, Stefan Horn

Publikováno v: Blood. 106:3958-3961

Multiple genetic alterations are required to induce acute myelogenous leukemia (AML). Mutations in the extracellular domain of the KIT receptor are almost exclusively found in patients with AML carrying translocations or inversions affecting members

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99bc36255fe32d5066c13649beb0129
https://doi.org/10.1182/blood-2005-02-0583

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Downregulation of c-kit (Stem Cell Factor Receptor) in Transformed Hematopoietic Precursor Cells by Stroma Cells

Autor: Ulla Bergholz, Martina Bögel, Christine Laker, Christoph Heberlein, Wolfram Ostertag, Dorothee von Laer, Karl Klingler, Leonie K. Ashman, Jutta Friel

Publikováno v: Blood. 93:554-563

We show a dramatic downregulation of the stem cell factor (SCF) receptor in different hematopoietic cell lines by murine stroma. Growth of the human erythroid/macrophage progenitor cell line TF-1 is dependent on granulocyte-macrophage colony-stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a723918aa970b22d9656e35c1cd6d15
https://doi.org/10.1182/blood.v93.2.554

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Runx1 is essential at two stages of early murine B-cell development

Autor: Susanne Roscher, Marion Ziegler, Neele Kriebitzsch, Kira Behrens, Meike Fischer, Frank Buchholz, Carol Stocking, Ursula Müller, Birte Niebuhr, Malik Alawi, Adam Grundhoff, Thomas Günther, Ulla Bergholz

Publikováno v: Blood. 122(3)

The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56d8d81b2a467b16edd9662588c1a76
https://pubmed.ncbi.nlm.nih.gov/23704093

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Adaptor Protein Lnk Binds to and Inhibits Normal and Leukemic FLT3

Autor: Ulla Bergholz, Carol Stocking, Lars Rönnstrand, De-Chen Lin, Tong Yin, Maya Koren-Michowitz, H. Phillip Koeffler, Julhash U. Kazi, Takayuki Tabayashi, Saskia Gueller, Sigal Gery, Ling-Wen Ding

Abstract 1312 Background The production and lineage commitment of hematopoietic cells is controlled by the actions of a complex network of signaling pathways. Mutations and translocations of tyrosine kinases within these pathways lead to constitutive

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Distinct Classes of Factor-Independent Mutants can be Isolated after Retroviral Mutagenesis of a Human Myeloid Stem Cell Line

Autor: Karl Klingler, Atsushi Miyajima, Carol Stocking, Thomas Wagener, Christian Starke, Jutta Friel, Wolfram Ostertag, Ulla Bergholz, Toshio Kitamura

Publikováno v: Growth Factors. 8:197-209

Retroviral insertion mutagenesis has been used extensively in vivo but not in vitro to induce and identify critical mutations during oncogenic progression and differentiation. We have developed a tissue culture system using the human, growth factor-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088f21c6b446fe54cd74ce1f55226c36
https://doi.org/10.3109/08977199309011023

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Identification of the Myelin Protein Plasmolipin as the Cell Entry Receptor for Mus caroli Endogenous Retrovirus▿

Autor: Marion Ziegler, A. Dusty Miller, Carol Stocking, Ulla Bergholz

The Asian wild mouse species Mus caroli harbors an endogenous retrovirus (McERV) that is closely related to but distinct from the endogenous retrovirus family defined by the Mus dunni endogenous virus and the Mus musculus endogenous retrovirus. McERV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1756580c62285cbf49cb8b70563d4d0
https://europepmc.org/articles/PMC2446966/

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Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells

Autor: Ulla Bergholz, Manfred Jücker, Lorenz Trümper, Carol Stocking, James A. McCubrey, Jörg Bäsecke, Stefan Horn

Publikováno v: Oncogene. 27(29)

Constitutive activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway is observed in up to 70% of acute myelogenous leukemia. To investigate the relevance of an intrinsic PI3K-AKT pathway activation in hematopoietic malignancies, we analysed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13791801c20996b5b53186c9258f606e
https://pubmed.ncbi.nlm.nih.gov/18317450

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Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model

Autor: Anthony M. Ford, Jürgen Löhler, Mel Greaves, Meike Fischer, Ulla Bergholz, Susanne Roscher, Birte Niebuhr, Maike Schwieger, Carol Stocking, Stefan Horn

Publikováno v: Oncogene. 24(51)

The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf45582bf75bba3270157a57209e58c
https://pubmed.ncbi.nlm.nih.gov/16044150

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