7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier

Autor: Ahmed Saeed, Federico Floris, Ulla Andersson, Irina Pikuleva, Anita Lövgren-Sandblom, Maria Bjerke, Martin Paucar, Anders Wallin, Per Svenningsson, Ingemar Björkhem

Publikováno v: Journal of Lipid Research, Vol 55, Iss 2, Pp 313-318 (2014)

There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We con

Externí odkaz: https://doaj.org/article/59a7314806d24d4a9fc206a8a02a6f57

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1

Autor: Dilyara A. Murtazina, Ulla Andersson, In-Su Hahn, Ingemar Bjorkhem, G.A.S. Ansari, Irina A. Pikuleva

Publikováno v: Journal of Lipid Research, Vol 45, Iss 12, Pp 2345-2353 (2004)

Cytochrome P450 27A1 (P450 27A1) is an important metabolic enzyme involved in bile acid biosynthesis and the activation of vitamin D3 in mammals. Recombinant P450 27A1 heterologously expressed in Escherichia coli was found to be copurified with phosp

Externí odkaz: https://doaj.org/article/cb0e3b500f36481cb90a84859144de8e

Annual report SWEDEHEART 2012

Autor: Anna-Maria Wahlberg, Magdalena Alenström, Stina Udin, Tore Johansson, Anna Lundgren, Birgitta Romany Johansson, Carin Ekström, Nils Eriksson, Lisbeth Andersson, Hanna Eklund, Lotta Robertsson, Gunilla Bjerhag, Ann-Charlotte Gustavsson, Madelene Israelsson, Sofia Karlsson, Maria Westerlund, Yvonne Ek, Birgitta Stenbäck, Barbro Andersson, Elisabeth Andersson, Kristina Leppämäki, Anette Ramirez, Victoria Wallin, Alexandra Lundberg, Benny Sahlin, Hasse Mälberg, Maria Liljeroos, Caroline Gustafsson, Kerstin Nyström, Susanne Siklo, Eva Zelleroth, Finn Hjortevang, Kamaran Mohammed, Agneta Hellblad, Iwona Schön, Kristina Carlsson, Marita Ole´rs, Pär Lennart Ågren, Iwar Sjögren, Crister Zedigh, Kristina Eriksson, Kristina Sundkvist, Anna-Karin Thorsell, Ann-Kristin Kuoljok, Linda Liinanki, Mona Liljergren, Sara Turtola, Britt-Marie Nylander, Lena Nordvall, Malin Nilsson, Annelie Blomqvist, Håkan Sjöberg, Jenny Nylander, Linda Berglund, Linda Mossberg, Lars Svennberg, Espen Haugen, Lars Hellsten, Staffan Johansson, Birgitta Johansson, Pethra Larsson, Susanne Kellerth, Monika Bergström, Carola Gustafsson, Cecilia Nährström, Eva Evenås, Hanna Sundin, Helena Lönn, Johan Svensson, Moa Kihlgren, Per Larsson, Pirjo Palosaari, Susann Johansson, Malin Cedermark magnusson, Annica Ravn-Fischer, Ann Wittfeldt, Elisabeth Perers, Nina Hellberg, Mikael Holmberg, Bert Andersson, Berit Jangsten, Nedim Selimovic, Anna Enström, Göran Dellgren, Henrik Scherstén, Anna Biveby-Nilsson, Johan Lundberg, Elmir Omerovic, Petur Petursson, Per Albertsson, Carina Ankarstrand, Agneta Flinck, Titti Larsson, Maria Samuelsson, Peter Bergman, Lotten Nyström, Magnus Bågenholm, Anneli Linnér, Björn Hornestam, Helén Sjöland, Anne-Marie Kirkhoff, Hugo Månsson, Ida Karlsson, Maria Olausson, Charlotte Berne, Christina Backe, Ali Tabandeh, Ann-Charlotte Karlsson, Peter Hårdhammar, Sven-Erik Olsson, Henrik Persson, Ole Wagner, Henrik Wagner, Lennart Sandhall, Carina Wåhlander, Kristina Rova, Lina Fischer, Maria Nilsson, Mari Stjernberg, Sylvia Gustavsson, Camilla Hedberg, Jan Thollander, Katarina Collberg, Jörg Lauermann, Werner Puskar, Margareta Larsson, Ann Johansson, Lina Brindstedt, Marina Olofsson, Jörg Carlsson, Katarina Månsson, Ulla Jeppsson, Ingbritt Söderlind, Malinn Hultman, Sara Ronnelin, Carina Fredriksson, Gerd Skogman, Ingela Ågren, Inger Almroth, Sara Trege Nilsson, Gerd Pettersson, Ing-Marie Åkesson, Sofia Carlfelter, Jan Medin, Karim Mokhtar, Carl-Magnus Pripp, Linda Malmsten, Annelie Karlsson, Anna Lenberg, Annika Lettenström, Anna Jost-Widén, Gunilla Johnson, Håkan Ahlmark, Hannah Brevik, IngaLill Nordberg, Jessica Österberg-Persson, Jeanette Smedberg, Maria Eklund, Urban Haaga, Anne-Marie Henriksson, Mats Allared, Hans Olsson, Tage Nilsson, Lisa Juhlin, Karin Eriksson, Leif Hedquist, Ulla Lundin, Christin Jonsson, Monica Pedersen, Julia Marainen, Moa Bylund, Monica Alsterdal, Anna Sjöberg, Ewa Wigenstorp, Gunilla Peterzen, Kerstin Skeppstedt, Anette Berlin, Helena Wikström, Kerstin Pihl, Lehna Ferm, Petra Larsson, Vanja Johansson, Gunvor Finnas, Helen Ahlm, Anders Ekelind, Eva Larsson, Gull-Britt Eriksson, Veronica Sass, Åsa Johansson, Lennart Malmqvist, Lars Westin, Eydis Sigurjonsdottir, Frida Skuladottir, Maria Ottesen, Olga Birgitta Bjarnadottir, Gunnar Myrdal, Edda Traustadottir, Friðrika Sigvaldadóttir, Gerður Garðarsdóttir, Gudrun Valgeirsdottir, Sigurlaug Magnusdottir, Thora Bjornsdottir, Thorarinn Gudnason, Svava Matthiasdottir, Maria Jonsson, Ulrika Pettersson, Magnus Peterson, Karin Molander, Micael Larsson, Berit Samuelsson, Catarina Svensson, Elisabeth Augustsson, Evelin BertilssonFröjd, Joakim Alfredsson, Wolfgang Freter, Linda Lilja, Gunnel Andersson, Dimitrios Venetsanos, Anders Björkholm, Tim Tödt, Ulf Berglund, Niels Erik Nielsen, Jenny Johansson, Johanna Svensson, Rosie-Marie Larsson, Liselotte Lundmark, Gunilla Brolin, Annika Westergren, Anna Duckert, Vesna Steffan, Matthias Götberg, David Erlinge, Fredrik Scherstén, Göran Olivecrona, Jan Harnek, Per Bondesson, Pernilla Knutsson, Evy Stenlund, Peter Thorén, Siv Algotsson, Enisa Durakovic, Lisa Gustafsson, Marie Nilsson, Margareta Nilson, Pallonji Bhiladvala, Monica Håkansson, Carina Svensson, Ingela Olsson, Amelie Kjellstenius, Jenny Åslund, Linnéa Alledal, Nina Varblane, Victoria Nilsson, Maria Thudén, Siv-Britt Jensen, Elisabet Svensson, Maria Pettersson, Sanna Lindgren, Anita Pehrsson, Maria Olsson, Anneli Rudenäs, Eva Öhman, Stig-Åke Falk, Annelie Jaensson, Lena Thell, Annette Billqvist, Barbro Efraimsson-Nilsson, Ingalill Allansson, Malin Jansson, Ann Ingström, Christina Lundqvist, Ingela Nyström, Ingrid Bergman, Johan Ekman, Lena Carlson, Solveig Person, Ingrid Lindberg, Leif Thuesen, Erik Lindberg, Gunnilla Lundberg, Kerstin Hedberg, Inga-Lill Kotka, Anja Fogelberg, Anna Johansson, Lis Ståhl, Anders Kallryd, Agneta Ramén, Henrik Löfmark, Senait Fessahaie, Malin Brandrup-Wognsen, Claire Salomonsson, Petra Ardin, Eva Balcker, Filippa Högberg, Fredrik Högberg, Eva Hultin Ånnegård, Marcus Svensson, Marie Tornestedt, Inge Björkander, Cathrine Edström, Lars Eurenius, Ann Samnegård, Jonas Persson, Nikolaos Östlund Papadogeorgos, Habib Mir-Akbari, Görel Stengård, Elin Bacsovics Brolin, Katarina Brehmer, Fauzia Osman, Marie Törnblom, Katja Sundkvist, Caroline Kumhala, Ellinor Jonsson, Alexandra Yazar, Anwar Siddiqui, Andreas Rück, Loghman Henareh, Kerstin Cederlund, Ewa Lemberg, Elin Larsson, Amanda Persson, Karolin Andersson, Per Svensson, Fauzia A - Moalim, Ann Lundgren, Ellen Gustavsson-segerhag, Agneta Nordvall, Gunnel Söderlund, Christina Jarnert, Linda Mellbin, Torbjörn Ivert, Rikard Linder, Mattias Törnerud, Birgit Edén, Kristina Lockne, Sebastian Rennerskog, Jan Kosmack, Marianne Erlandsson, Pontus Lindroos, Armi Peltonen, Christine Creutziger, Ellinor Berglund, Marie Henriksson, Carina Ingeborn, Olov Collste, Mikael Aasa, Karin Karlsson, Ulla Andersson, Lis Kohlström Englund, Mia Henning, Anna-Greta Vinblad v Walter, Christina Nilsson, Helena Schilken, Inger Johansson, Ingrid Wallgren, Kristina Niemi, Oili Niva, Margareta Dofs, Agneta Johansson, Jan Haupt, Christina Näslund, Henrik Drewsen, Maria Söderlund, Birgitta Berts, Bo Lindvall, Daniel Wadell, Jens Jensen, Åsa Hedh, Karin Johnson, Cecilia Nikitin, Eva-Lena Eriksson, Elisabeth Westlund, Inger Karlsson, Peter Björkdahl, Radim Uher, Ulf Nyman, Troels Yndigegn, Anette Broberg, Linda Lamreus, Alexandra Söderström, Marianne Lång, Henrik Olsson, Madhat Hussien Al-Saadi, Emma Landén, Maria Holmgren, Tomas Rivera San Martin, Karin Nyström, Magnus Wahlin, Oskar Angerås, Johan Nilsson, Peter Eriksson, Anna Sundberg, Inger Sandström, Olov Duvernoy, Maria Andreasson, Johanna Ekström, Marie Essermark, Helena Wall, Elisabeth Marklund, Cecilia Östlund, Maria Willehadson, Christina Björklund, Axel Dimberg, Vitas Zemgulis, Agneta Olsson, Susanne Hagström, Carina Bergman, Annika Gunnarsson, My Huhta, Christina Svensson, Per Hultman, Christoph Varenhorst, Per Kvidal, Annika Stener Bengtsson, Ann-Lis Wännman, Lisbeth Nilsson, Tomas Andersson, Maritha Josefsson, Maria Morén, Lena Hultman-Berg, Anna-Karin Almqwist, Monica Cederblad, Katarina Ekberg, Gunilla Kvarnvik, Eston Jönsson, Annelie Hammerman, Pia Claesson, Gith Widerström, Sandra Pettersson Olsson, Åsa Hofvander, Martin Lindholm, Saman Saidi, Per Grimfjärd, Amra Kåregren, Madeleine Runesson, Anders Josefsson, Lena Henriksson-Fri, Miriam Johansson, Solgärd Gustavsson, Minna Markljung, Olle Bergström, Thomas Aronsson, Ewa Karlsson, Pernilla Boström, Sofia Hansson, Inger Andreasson, Lena Palmqvist, Anders Kähäri, Mats Lidén, Frida Oskarsson, Ingela Östman, Johanna Kronberg, Marie Johansson, Marie Thuresson, Håkan Geijer, Ole Fröbert, Thomas Kellerth, Maud Tillkvist, Kirsti Ajax, Fredrik Björklund, Anna Björklund

Publikováno v: Scandinavian Cardiovascular Journal. 48:2-133

According to Swedish National Board of Health and Welfare statistics, a dramatic decrease in both the incidence of and mortality from acute myo-cardial infarction has been seen in the past two deca...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::833644d6ed979874b894408b13d791c3
https://doi.org/10.3109/14017431.2014.931554

Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1)

Autor: Lena Ekström, Gösta Eggertsen, Elena Feinstein, Ulla Andersson, Maura Heverin, Maria Olin, Ulf Diczfalusy, Ingemar Björkhem, Millicent Shafir, Yoshihiko Ohyama, Steve Meaney, Anat Brafman

Publikováno v: Journal of Biological Chemistry. 281:3810-3820

Mammalian CNS contains a disproportionally large and remarkably stable pool of cholesterol. Despite an efficient recycling there is some requirement for elimination of brain cholesterol. Conversion of cholesterol into 24S-hydroxycholesterol by the ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e58ffc21ec589db7ece93ffc85f062c
https://doi.org/10.1074/jbc.m505179200

Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12α-hydroxylase gene (CYP8B1)

Autor: Mats Gåfvels, Yi-Zeng Yang, Ingemar Björkhem, Curt Einarsson, Ulla Andersson, Gösta Eggertsen, John Y.L. Chiang

Publikováno v: Biochemical and Biophysical Research Communications. 320:1204-1210

Sterol 12α-hydroxylase (CYP8B1) is an obligatory enzyme for the synthesis of cholic acid and regulation of liver bile acid synthesis and intestine cholesterol absorption. The present study evaluates the roles for sterol regulatory element binding pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd34975a7799a72bf2d7dc048aa3659
https://doi.org/10.1016/j.bbrc.2004.06.069