Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Uli S, Herrmann"'
Autor:
Regina R Reimann, Tiziana Sonati, Simone Hornemann, Uli S Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005401 (2016)
Antibodies against the prion protein PrPC can antagonize prion replication and neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases. However, the safety profile of such antibodies is controversial. It was original
Externí odkaz:
https://doaj.org/article/76ecf16ee8974d819f2f80a8602d9b28
Publikováno v:
Advances in immunology. 152
Neuropsychiatric diseases have traditionally been studied from brain, and mind-centric perspectives. However, mounting epidemiological and clinical evidence shows a strong correlation of neuropsychiatric manifestations with immune system activation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cd1e0dbbc6978261fbea7204c6bf910
https://pubmed.ncbi.nlm.nih.gov/34844710
https://pubmed.ncbi.nlm.nih.gov/34844710
Autor:
Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004808 (2015)
[This corrects the article DOI: 10.1371/journal.ppat.1004662.].
Externí odkaz:
https://doaj.org/article/cad35e58d6524f12b325279b629c74d4
Autor:
Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004662 (2015)
Prions induce lethal neurodegeneration and consist of PrPSc, an aggregated conformer of the cellular prion protein PrPC. Antibody-derived ligands to the globular domain of PrPC (collectively termed GDL) are also neurotoxic. Here we show that GDL and
Externí odkaz:
https://doaj.org/article/2f192076206246ed93ed98f65be2e327
Autor:
Paolo Dametto, Asvin K K Lakkaraju, Claire Bridel, Lukas Villiger, Tracy O'Connor, Uli S Herrmann, Pawel Pelczar, Thomas Rülicke, Donal McHugh, Arlind Adili, Adriano Aguzzi
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117412 (2015)
The cellular prion protein (PrPC) consists of a flexible N-terminal tail (FT, aa 23-128) hinged to a membrane-anchored globular domain (GD, aa 129-231). Ligation of the GD with antibodies induces rapid neurodegeneration, which is prevented by deletio
Externí odkaz:
https://doaj.org/article/2e3d82e5926f49f0845922f028313aac
Autor:
Emina Lemes, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi, Uli S. Herrmann, Karl Frontzek, Asvin K. K. Lakkaraju
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
Brain‐matter vacuolation is a defining trait of all prion diseases, yet its cause is unknown. Here, we report that prion infection and prion‐mimetic antibodies deplete the phosphoinositide kinase PIKfyve—which controls endolysosomal maturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135d7fea8e3251ca7565f5dddb6d990e
https://doi.org/10.1101/2021.01.08.425896
https://doi.org/10.1101/2021.01.08.425896
Publikováno v:
Advances in Immunology ISBN: 9780128246009
Neuropsychiatric diseases have traditionally been studied from brain, and mind-centric perspectives. However, mounting epidemiological and clinical evidence shows a strong correlation of neuropsychiatric manifestations with immune system activation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6edaa7e3745ae2330b833b5f22b9cd2c
https://doi.org/10.1016/bs.ai.2021.09.002
https://doi.org/10.1016/bs.ai.2021.09.002
Autor:
Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1002985 (2012)
Prions cause neurodegeneration in vivo, yet prion-infected cultured cells do not show cytotoxicity. This has hampered mechanistic studies of prion-induced neurodegeneration. Here we report that prion-infected cultured organotypic cerebellar slices (C
Externí odkaz:
https://doaj.org/article/4d93c9906020487fbbfde99e7148a661
Autor:
Eliezer Masliah, Adriano Aguzzi, Radoslav I. Enchev, Petra Schwarz, Thibault Courtheoux, Matthias Peter, Anthony Adame, Juan Gerez, Paola Picotti, Paul J. Boersema, Uli S. Herrmann, Natalia Cecilia Prymaczok, Roland Riek, Edward Rockenstein
Parkinson’s disease (PD) is a neurological disorder characterized by the progressive accumulation of neuronal α-synuclein (αSyn) inclusions called Lewy bodies. It is believed that Lewy bodies spread throughout the nervous system due to the cell-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21036f343bf70896f02fe82414a6570
https://doi.org/10.5167/uzh-172491
https://doi.org/10.5167/uzh-172491
Autor:
Simon Hawke, Simone Hornemann, Michael Arand, Uli S. Herrmann, Tiziana Sonati, Adriano Aguzzi, Regina Reimann
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 1, p e1005401 (2016)
PLOS Pathogens
PLoS Pathogens, Vol 12, Iss 1, p e1005401 (2016)
PLOS Pathogens
Antibodies against the prion protein PrPC can antagonize prion replication and neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases. However, the safety profile of such antibodies is controversial. It was original
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627ceb0905a5f9b3762b20b1ed79b6e2
http://europepmc.org/articles/PMC4731068
http://europepmc.org/articles/PMC4731068