Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ulhas Bhatt"'
Publikováno v:
Synthetic Communications. 37:2793-2806
The regioselective syntheses of two pharmaceutically relevant pyrrole scaffolds are described. A synthetic route for the preparation of differentially substituted pyrrole‐3,4‐dicarboxylates is presented and exemplified. This route circumvents som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2320d1b3250936e12bf4155414ae3b59
https://doi.org/10.1080/00397910701481237
https://doi.org/10.1080/00397910701481237
Autor:
William B. Geiss, Jörgen Jensen, Susanne Elg, Gunilla Jerndal, Jan P. Mattsson, Karolina Nilsson, Lena Brändén, Anders Lehmann, Marianne Bremner-Danielsen, Peter R. Guzzo, Britt-Marie Olsson, Ulhas Bhatt, Kevin Fitzpatrick, Thomas Elebring, Ann Aurell Holmberg
Publikováno v:
British Journal of Pharmacology. 146:89-97
The effects of the novel GABA analogue (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxations (TLOSRs) were studied in the dog. In addition, the GABA(A)/GABA(B) selectivity was determined in vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17fb6d098d487efff0166777f7b308f0
https://doi.org/10.1038/sj.bjp.0706299
https://doi.org/10.1038/sj.bjp.0706299
Publikováno v:
Organic Letters. 6:3889-3892
[structure: see text] The synthesis of the A,B,C-ring system (2) of hexacyclinic acid (1) is achieved starting from a selective Diels-Alder reaction followed by vinyl cuprate addition. The diastereoselective reduction of the ketone carbonyl at C16 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef9b4a22118989ce86b72309370bc6a
https://doi.org/10.1021/ol048720o
https://doi.org/10.1021/ol048720o
Autor:
Min Hu, Snjezana Lelas, Michael Sinz, Yuri L. Khmelnitsky, Dennis Milanowski, Anne Payen-Fornicola, Matthew Isherwood, Dalton King, Nicholas Holman, Carla Hassler, Wenge Cui, Jonathan O’Connell, Yuh-Lin Yang, Ulhas Bhatt, Nicholas J. Lodge, Yu-Wen Li, Roy Haskell, John E. Macor, Sargent Bruce J, Kim A. Johnson, Linda Fleming, Stephen P. Adams, Vadim V. Mozhaev, Sarah M. Ebeltoft, Shuang Liu, Thaddeus F. Molski, Sambandam Aruna, Richard E. Olson, Congxiang Zha, Robert L. Bertekap, Bruce F. Molino, Wendy Clarke, Robert Zaczek, Anthony D. Pechulis, Michael Herr, Peter R. Guzzo, Larry Yet, Alicia Ng, Anitra F. Orie, Ian C. Cotterill, Kassoum Nacro
Publikováno v:
ACS medicinal chemistry letters. 5(7)
A series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) was discovered. The synthesis and structure-activity relationship (SAR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d5735ba509f2dee5e16c0853dacd5b
https://pubmed.ncbi.nlm.nih.gov/25050161
https://pubmed.ncbi.nlm.nih.gov/25050161
Publikováno v:
Angewandte Chemie. 112:4535-4538
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23b85fac0620f85f49cfe362101640d
https://doi.org/10.1002/1521-3757(20001201)112:23<4535::aid-ange4535>3.0.co
https://doi.org/10.1002/1521-3757(20001201)112:23<4535::aid-ange4535>3.0.co
Synthesis of a Novel Thyrotropin Releasing Hormone (TRH) Analog Incorporating a Piperazin-2-one Ring
Autor:
George Just, Ulhas Bhatt
Publikováno v:
Helvetica Chimica Acta. 83:722-727
The synthesis of a Thyrotropin Releasing Hormone (TRH) analog incorporating a piperazin-2-one ring is described. This conformationally restricted peptidomimetic attempts to retain the key recognition elements of the interaction between TRH and its re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75964b1534ea5ca3d5123dfcdc41ca6
https://doi.org/10.1002/(sici)1522-2675(20000412)83:4<722::aid-hlca722>3.0.co
https://doi.org/10.1002/(sici)1522-2675(20000412)83:4<722::aid-hlca722>3.0.co
Publikováno v:
Tetrahedron Letters. 39:8213-8216
The synthesis of substituted oxopiperazines, which may act as conformationally constrained peptide mimics, is reported. The synthesis is based on the cyclization of sulfonamide dipeptides with dibromoethane as the 1,2-dielectrophile. Alternatively, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::111c55ac7a88ea0538717f05ecfb89eb
https://doi.org/10.1016/s0040-4039(98)01878-4
https://doi.org/10.1016/s0040-4039(98)01878-4
Publikováno v:
Tetrahedron Letters. 38:3679-3682
Two routes for the synthesis of derivatized oxopiperazines, which may act as constrained peptide mimics, are reported. The syntheses employ reductive amination and sulfonamide approaches for generating N-allylic amino acid ester derivatives and utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f56210eeb9d1ac3f05c8af95dd8aeae
https://doi.org/10.1016/s0040-4039(97)00726-0
https://doi.org/10.1016/s0040-4039(97)00726-0
Autor:
Ulhas Bhatt
Publikováno v:
ChemInform. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b08a7775a642b99ceed41816775d17
https://doi.org/10.1002/chin.201201256
https://doi.org/10.1002/chin.201201256
Publikováno v:
Tetrahedron Letters. 42:1263-1265
Natural products like ratjadone and callystatin A contain an α,β-unsaturated lactone moiety which adds to the biological activity of these compounds. Here we report a rapid and practical access to lactone precursor 3 by an asymmetric hetero Diels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af65f625b12118a11786e137d24abf04
https://doi.org/10.1016/s0040-4039(00)02213-9
https://doi.org/10.1016/s0040-4039(00)02213-9