Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Ulf Simonsen"'
Autor:
Åsa Lina M. Jönsson, Ole Hilberg, Ulf Simonsen, Jane Hvarregaard Christensen, Elisabeth Bendstrup
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive lung disease caused by variants in the SLC34A2 gene encoding the sodium-dependent phosphate transport protein 2B, NaPi-2b. PAM is characterized by deposition of calcium ph
Externí odkaz:
https://doaj.org/article/eda338914ccf4ad78ba9a4d7be092085
Autor:
Patrik Aronsson, Johanna Stenqvist, Ena Ferizovic, Emelie Danielsson, Anna Jensen, Ulf Simonsen, Michael Winder
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Due to its chemical properties, functional responses to nitric oxide (NO) are often difficult to examine. In the present study, we established a method to produce NO in an aqueous solution and validated its capacity to evoke functional
Externí odkaz:
https://doaj.org/article/e0906a673e284dd1bf114239d20d3ff4
Autor:
Agilė Tunaitytė, Silvijus Abramavičius, Augusta Volkevičiūtė, Mantas Venslauskas, Algimantas Bubulis, Vytis Bajoriūnas, Ulf Simonsen, Vytautas Ostaševičius, Vytautas Jūrėnas, Kasparas Briedis, Edgaras Stankevičius
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 257 (2024)
The present study aimed to investigate the effect of a H2S donor, GYY 4137, on human pulmonary arteries and whether low-frequency ultrasound (20 kHz, 4 W/cm2) inhibits GYY 4137 contractions. Functional studies were conducted on human and rat pulmonar
Externí odkaz:
https://doaj.org/article/d303bbda2d9e4f6f94cae14bb55f44cf
Autor:
Åsa Lina M. Jönsson, Nati Hernando, Thomas Knöpfel, Susie Mogensen, Elisabeth Bendstrup, Ole Hilberg, Jane Hvarregaard Christensen, Ulf Simonsen, Carsten A. Wagner
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-11 (2022)
Abstract Background Variants in SLC34A2 encoding the sodium-dependent phosphate transport protein 2b (NaPi-IIb) cause the rare lung disease pulmonary alveolar microlithiasis (PAM). PAM is characterised by the deposition of calcium-phosphate concretio
Externí odkaz:
https://doaj.org/article/b26c4688d07040dca763b1684c455225
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11826 (2023)
Despite recent advances in heart failure (HF) therapy, the risk of cardiovascular (CV) mortality, morbidity, and HF hospitalization (HFH) are major challenges in HF treatment. We aimed to review the potential of vericiguat as a treatment option for H
Externí odkaz:
https://doaj.org/article/8b31f3b4308e42abb1914cf06aed6cbd
Autor:
Karen Axelgaard Lorentzen, Raquel Hernanz, Estéfano Pinilla, Jens Randel Nyengaard, Lise Wogensen, Ulf Simonsen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8436 (2023)
Diabetic macroangiopathy is characterized by increased extracellular matrix deposition, including excessive hyaluronan accumulation, vessel thickening and stiffness, and endothelial dysfunction in large arteries. We hypothesized that the overexpressi
Externí odkaz:
https://doaj.org/article/e6d4b27f3ea54198a15341131723683f
Autor:
Asbjørn G. Petersen, Peter C. Lind, Anne-Sophie B. Jensen, Mark A. Eggertsen, Asger Granfeldt, Ulf Simonsen
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Senicapoc is a potent and selective blocker of KCa3.1, a calcium-activated potassium channel of intermediate conductance. In the present study, we investigated whether there is a beneficial effect of senicapoc in a large animal mo
Externí odkaz:
https://doaj.org/article/0f96c432b6844668824cc00292f1418f
Autor:
Justina Jokšienė, Jayashree Sahana, Markus Wehland, Herbert Schulz, José Luis Cortés-Sánchez, Judit Prat-Duran, Daniela Grimm, Ulf Simonsen
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 189 (2023)
A diabetogenic state induced by spaceflight provokes stress and health problems in astronauts. Microgravity (µg) is one of the main stressors in space causing hyperglycaemia. However, the underlying molecular pathways and synergistic effects of µg
Externí odkaz:
https://doaj.org/article/9026744718a74e32aab4ec87f567665c
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Exposure to hypobaric hypoxia at high altitude puts mountaineers at risk of acute mountain sickness. The carbonic anhydrase inhibitor acetazolamide is used to accelerate acclimatization, when it is not feasible to make a controlled and slow ascend. S
Externí odkaz:
https://doaj.org/article/26232ce0b9894b43b26a73bb4242a33a
Autor:
Junjing Su, Ulf Simonsen, Soren Mellemkjaer, Luke S. Howard, Charlotte Manisty, Alun D. Hughes
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract We explored the use of the augmentation index (AI) based on pulse wave analysis (PWA) in the pulmonary circulation as a measure of wave reflection and arterial stiffness in individuals with and without pulmonary arterial hypertension (PAH) a
Externí odkaz:
https://doaj.org/article/14acb3e3cac0479ab80d132622f67a6f