Výsledky vyhledávání - "Ulf Siemoneit"

Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense

Autor: Ulf Siemoneit, Antonietta Rossi, Thorsten J. Maier, Oliver Werz, Moritz Verhoff, Sina Reckel, Lidia Sautebin, Andreas Koeberle, V Doetsch, Friederike Dehm, Johann Jauch, Hinnak Northoff, Frank Bernhard

Publikováno v: British Journal of Pharmacology. 162:147-162

BACKGROUND AND PURPOSE Frankincense, the gum resin derived from Boswellia species, showed anti-inflammatory efficacy in animal models and in pilot clinical studies. Boswellic acids (BAs) are assumed to be responsible for these effects but their anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47596dd9e8f26c6007debd575a6818cb
https://doi.org/10.1111/j.1476-5381.2010.01020.x

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Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense

Autor: Nicole Kather, Arne Henkel, Oliver Werz, Gisbert Schneider, Michael Karas, Lars Tausch, Johann Jauch, Carsten Skarke, Daniel Poeckel, Tobias Beckhaus, Ulf Siemoneit, Gerd Geisslinger, Lutz Franke, Bettina Hofmann, Carlo Angioni, Wolfgang Holtmeier

Publikováno v: The Journal of Immunology. 183:3433-3442

Frankincense preparations, used in folk medicine to cure inflammatory diseases, showed anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) constitute major pharmacological principles of frankincense, but their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2c03bfd4ced6de57b8844b85fca985
https://doi.org/10.4049/jimmunol.0803574

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Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

Autor: Oliver Werz, Ulrike Bühring, Hinnak Northoff, Wolfgang Albrecht, Stefan Laufer, Andreas Koeberle, Ulf Siemoneit

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 326:975-982

The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid], currently undergoing phase III trials for osteoarthritis, inhibits the prostaglandin (PG) and leukotriene biosyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcbe1754b18f5f8221e3626fd0f3422
https://doi.org/10.1124/jpet.108.139444

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Acrylic/cyclodextrin hydrogels with enhanced drug loading and sustained release capability

Autor: Francisco J. Otero-Espinar, Angel Concheiro, Carmen Alvarez-Lorenzo, José Blanco-Méndez, Asteria Luzardo, Ulf Siemoneit, Christoph Schmitt

Publikováno v: International Journal of Pharmaceutics. 312:66-74

The influence of the proportion of acrylamidomethyl-gamma-cyclodextrin (gamma-CD-NMA) on loading and release of the hydrophobic triamcinolone acetonide (TA) and the hydrophilic propranolol (PR) by acrylic acid hydrogels was evaluated. gamma-CD-NMA wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323fffe5cd95d8bc017ed36b14410f23
https://doi.org/10.1016/j.ijpharm.2005.12.046

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On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance

Autor: Bianca Jazzar, Carlo Pergola, Oliver Werz, Carsten Skarke, Ulf Siemoneit, Johann Jauch, Hinnak Northoff

Publikováno v: European journal of pharmacology. 606(1-3)

Boswellic acids are pharmacologically active ingredients of frankincense with anti-inflammatory properties. It was shown that in vitro 11-keto-boswellic acids inhibit 5-lipoxygenase (5-LO, EC 1.13.11.34), the key enzyme in leukotriene biosynthesis, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b56abe44ac8da39ba64d7e4e47c03d
https://pubmed.ncbi.nlm.nih.gov/19374837

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Boswellic acids from the anti-inflammatory remedy frankincense: Identification and functional analysis of novel molecular targets within the arachidonic acid cascacde

Autor: Oliver Werz, Ulf Siemoneit, Friederike Dehm, B. Hofmann, Daniel Poeckel, N. Kather, Gisbert Schneider, Johann Jauch

Publikováno v: Planta Medica. 74

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c59884be97ff51824435af6a57cd0ff4
https://doi.org/10.1055/s-0028-1083991

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Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids

Autor: Lutz Franke, Tobias Lamkemeyer, Oliver Werz, Nicole Kather, Johann Jauch, Daniel Poeckel, Gisbert Schneider, Johannes Madlung, Ulf Siemoneit, Bettina Hofmann

Publikováno v: Biochemical pharmacology. 75(2)

Boswellic acids (BAs) are assumed as the anti-inflammatory principles of Boswellia species. Initially, it was found that BAs inhibit leukotriene biosynthesis and 5-lipoxygenase (EC number 1.13.11.34), whereas suppression of prostaglandin formation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169493e51038eb02286a9eb0b83f3359
https://pubmed.ncbi.nlm.nih.gov/17945191

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