Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ulf Peters"'
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e409 (2007)
During cell division, chromosome segregation must be coordinated with cell cleavage so that cytokinesis occurs after chromosomes have been safely distributed to each spindle pole. Polo-like kinase 1 (Plk1) is an essential kinase that regulates spindl
Externí odkaz:
https://doaj.org/article/9ccca997837d485286c3d0ae16481a84
Autor:
Yi Liu, Pingda Ren, Anjali Babbar, Sarah J. Firdaus, Jeffrey H. Chen, Tess Ely, Jun Feng, Jeff M. Kucharski, Yuching Chen, Linda V. Kessler, Ulf Peters, Rasmus Hansen, Lian-Sheng Li, Matthew R. Janes, Matthew P. Patricelli
Supplementary Table 1. Biochemical and Cell engagement SAR. Supplementary Table 2. Data collection and refinement statistics (Molecular replacement). Supplementary Table 3. Selectivity of ARS-853 across KRAS isoforms and GTP vs. GDP states. Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4c1da5f413c618429e4a216ba9b29
https://doi.org/10.1158/2159-8290.22531619
https://doi.org/10.1158/2159-8290.22531619
Autor:
Dirk Wortmann, Ulf Peters
Publikováno v:
Ablaufsimulation in der Automobilindustrie ISBN: 9783662593875
Die Investitionen fur das neue Ersatzteilzentrum der Dr. Ing. h.c. F. Porsche AG in Sachsenheim (Landkreis Ludwigsburg) belaufen sich auf mehr als 100 Millionen Euro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03d56cb2f39356f292feb56f4a6141ba
https://doi.org/10.1007/978-3-662-59388-2_14
https://doi.org/10.1007/978-3-662-59388-2_14
Autor:
Ulf Peters, Rasmus Hansen, Matthew R. Janes, Lian-Sheng Li, Patrick Parvis Zarrinkar, Anjali Babbar, Jun Feng, Yuching Chen, Pingda Ren, Yi Liu
Publikováno v:
Nature Structural & Molecular Biology. 25:454-462
Activating mutations in KRAS are among the most common tumor driver mutations. Until recently, KRAS had been considered undruggable with small molecules; the discovery of the covalent KRASG12C inhibitors ARS-853 and ARS-1620 has demonstrated that it
Autor:
Rasmus, Hansen, Ulf, Peters, Anjali, Babbar, Yuching, Chen, Jun, Feng, Matthew R, Janes, Lian-Sheng, Li, Pingda, Ren, Yi, Liu, Patrick P, Zarrinkar
Publikováno v:
Nature structuralmolecular biology. 25(6)
Activating mutations in KRAS are among the most common tumor driver mutations. Until recently, KRAS had been considered undruggable with small molecules; the discovery of the covalent KRAS
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2253-2260
Methylation of histones by lysine methyltransferases (KMTases) plays important roles in regulating chromatin function. It is also now clear that improper KMTases activity is linked to human diseases, such as cancer. We report an approach that employs
Autor:
Jonathan W. Choy, Ulf Peters, Michael S. Lopez, Martin L. Sos, David O. Morgan, Kevan M. Shokat
Publikováno v:
Journal of the American Chemical Society. 135:18153-18159
Analog-sensitive (AS) kinase technology is a powerful approach for studying phospho-signaling pathways in diverse organisms and physiological processes. The key feature of this technique is that a kinase-of-interest can be mutated to sensitize it to
Publikováno v:
Nature. 503:548-551
Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies1–3. Efforts to target this oncogene directly have faced difficulties owi
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15046-15052
The conserved nature of the ATP-binding site of the > 500 human kinases renders the development of specific inhibitors a challenging task. A widely used chemical genetic strategy to overcome the specificity challenge exploits a large-to-small mutatio
Autor:
Carol Thach, Jeff Kucharski, Jingchuan Zhang, Yvonne Yao, Shuangwei Li, Anjali Babbar, Dashyant Dhanak, Rasmus Hansen, Yuan Liu, Yuching Chen, Pingda Ren, Ulf Peters, Yi Liu, Shisheng Li, Ke Yu, Yi Wang, Patrick Parvis Zarrinkar, Xiaohu Deng, Matthew R. Janes, Sarah J. Firdaus, Ata Zarieh, Lian-Sheng Li, Tao Wu, Xin Guo, Jun Feng, Matthew V. Lorenzi, Dana D. Hu-Lowe, Jeffrey H. Chen
Publikováno v:
Cancer Research. 78:929-929
Activating mutations in KRAS have a high prevalence in human cancer. The codon 12 glycine to cysteine missense mutation (KRASG12C) is among the most common KRAS mutations, present in non-small cell lung adenocarcinoma (~15 %), colorectal adenocarcino