Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Ulf Madsen"'
Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of
Autor:
Lars Olsen, Liwei Han, Jacob Ingemar Olsen, Ulf Madsen, Niklas Sköld, Tommy N. Johansen, Birgitte Nielsen, Darryl S. Pickering, Jesper L. Kristensen
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:5368-5377
In order to identify compounds selective for the GluK1 and GluK3 subtypes of kainate receptors we have designed and synthesized a series of (S)-2-amino-3-((2-carboxyethyl)phenyl)propanoic acid analogs with hydrogen bond donating and accepting substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d073457fbf78445b804ef48046ab2cc5
https://doi.org/10.1016/j.bmc.2014.07.045
https://doi.org/10.1016/j.bmc.2014.07.045
Autor:
Søren Møller Nielsen, Hans Bräuner-Osborne, Ulf Madsen, Trine Kvist, Birgitte H. Kaae, Birgitte Nielsen, Hermogenes N. Jimenez, Kasper Harpsøe, Rasmus P. Clausen, Christina Mølck, Michelle A. Uberti, David E. Gloriam, Jesper Mosolff Mathiesen, Per Sauerberg
Publikováno v:
ChemMedChem. 7:440-451
A series of compounds based on the mGluR5-selective ligand 2-methyl-6-(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to be either structural analogues of MPEP, substituted monomers, or dimeric analogues. All co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7774d86454abd58c47505cdaa9660566
https://doi.org/10.1002/cmdc.201100578
https://doi.org/10.1002/cmdc.201100578
Publikováno v:
Neuropharmacology. 60:135-150
Ionotropic glutamate receptors (iGluRs) constitute a family of ligand-gated ion channels that are essential for mediating fast synaptic transmission in the central nervous system. These receptors play an important role for the development and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbd55c7fa79690c84d1e3d3df66b372
https://doi.org/10.1016/j.neuropharm.2010.08.004
https://doi.org/10.1016/j.neuropharm.2010.08.004
Autor:
Hans Bräuner-Osborne, Domenico E. Pellegrini-Giampietro, Kasper B. Hansen, Andrea Pinto, Lucia Tamborini, Ulf Madsen, Eugenio Donato Di Paola, Carlo De Micheli, Giovambattista De Sarro, Paola Conti, Birgitte Nielsen, Elisa Landucci
Publikováno v:
ChemMedChem. 5:1465-1475
The design and synthesis of new N1-substituted 3-carboxy- and 3-phosphonopyrazoline and pyrazole amino acids that target the glutamate binding site of NMDA receptors are described. An analysis of the stereochemical requirements for high-affinity inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb41d618d1094ac1f5a03edeb3fe1d31
https://doi.org/10.1002/cmdc.201000184
https://doi.org/10.1002/cmdc.201000184
Autor:
Helle Hald, Ulf Madsen, D. Sprogoe, Michael Gajhede, Daniel B. Timmermann, Darryl S. Pickering, Tommy Liljefors, Peter Naur, Philip K. Ahring, Jan Egebjerg, Jette S. Kastrup, Arne Schousboe
Publikováno v:
Journal of Biological Chemistry. 282:25726-25736
More than 50 structures have been reported on the ligand-binding core of the ionotropic glutamate receptor iGluR2 that belongs to the 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid-type of receptors. In contrast, the ligand-binding core of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6e003e9460ee847d34c4611d6a505e
https://doi.org/10.1074/jbc.m700137200
https://doi.org/10.1074/jbc.m700137200
Autor:
Carlo De Micheli, Lucia Tamborini, Hans Bräuner-Osborne, Gabriella Roda, Birgitte Nielsen, Andrea Pinto, Paola Conti, Marco De Amici, Ulf Madsen
Publikováno v:
Tetrahedron. 63:2249-2256
The erythro- and threo-amino-(3′-hydroxy-4′,5′-dihydro-isoxazol-5′-yl)-acetic acids, stereoisomers of tricholomic acid, were synthesized along with the corresponding higher homologues erythro- and threo-amino-(3′-carboxy-4′,5′-dihydro-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed2b7eeba124a5f417f5dc1bf499b6c
https://doi.org/10.1016/j.tet.2006.12.066
https://doi.org/10.1016/j.tet.2006.12.066
Autor:
Valentina Vestri, Hans Bräuner-Osborne, Domenico E. Pellegrini-Giampietro, Jan Egebjerg, Giovanni Grazioso, Kasper B. Hansen, Marco De Amici, Birgitte Nielsen, Carlo De Micheli, Francine Acher, Andrea Pinto, Paola Conti, Ulf Madsen, Pauline Sibille, Gabriella Roda
Publikováno v:
Journal of Medicinal Chemistry. 48:6315-6325
The four stereoisomers of 5-(2-amino-2-carboxyethyl)-4,5-dihydroisoxazole-3-carboxylic acid(+)-4, (-)-4, (+)-5, and (-)-5 were prepared by stereoselective synthesis of two pairs of enantiomers, which were subsequently resolved by enzymatic procedures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73b26e04f62affa643cc7bcf5cce738
https://doi.org/10.1021/jm0504499
https://doi.org/10.1021/jm0504499
Autor:
Udo Meyer, Georg Höfner, August W. Frahm, Philippe Bisel, Klaus T. Wanner, Hans Bräuner-Osborne, Ulf Madsen
Publikováno v:
Chirality. 17:99-107
The second-generation asymmetric synthesis of the trans-tris(homoglutamic) acids reported herein proceeds via Strecker reaction of chiral ketimines, obtained from condensation of racemic 2-ethoxycarbonylmethylcyclopentanone and commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e274470fc03a529f4b83b362c164cf5a
https://doi.org/10.1002/chir.20110
https://doi.org/10.1002/chir.20110
Autor:
Ulf Madsen, Marco De Amici, Giovambattista De Sarro, Karla Frydenvang, Gabriella Roda, Lucio Toma, Paola Conti, Federico F. Barberis Negra, Tine B. Stensbøl, Birgitte Nielsen, Giovanni Grazioso, Hans Bräuner-Osborne, Carlo De Micheli
Publikováno v:
Journal of Medicinal Chemistry. 47:6740-6748
The two diastereomeric pairs of acidic amino acids 5-(2-amino-2-carboxyethyl)-4,5-dihydroisoxazole-3-carboxylic acid (8A/8B) and 4-(2-amino-2-carboxyethyl)-5,5-dimethyl-4,5-dihydroisoxazole-3-carboxylic acid (10A/10B) were prepared via a strategy bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8891478f60fae054f6e4425ecdfccb9
https://doi.org/10.1021/jm049409f
https://doi.org/10.1021/jm049409f