Výsledky vyhledávání - "Ulf M. Lindström"

Asymmetric synthesis of (+)-1-deoxynojirimycin and (+)-castanospermine

Autor: Patrice Marchand, Staffan Torsell, Ulf M. Lindström, Peter Somfai

Publikováno v: Tetrahedron. 59:1293-1299

Asymmetric total syntheses of (+)-1-deoxynojirimycin (1) and (+)-castanospermine (2) are described. Starting from diene 3, the required absolute stereochemistry is introduced by an asymmetric hydroxylation followed by epoxidation. An intramolecular c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ec5f517049862ea033c024ae00d42fa
https://doi.org/10.1016/s0040-4020(02)01660-5

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Artificial human telomeres from DNA nanocircle templates

Autor: Emin Oroudjev, Ravi A. Chandrasekaran, Gregory P. Miller, Lucian Orbai, Eric T. Kool, Helen G. Hansma, Sandra A. Helquist, Ulf M. Lindström

Publikováno v: Proceedings of the National Academy of Sciences. 99:15953-15958

Human telomerase is a reverse-transcriptase enzyme that synthesizes the multikilobase repeating hexamer telomere sequence (TTAGGG) n at the ends of chromosomes. Here we describe a designed approach to mimicry of telomerase, in which synthetic DNA nan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52e6714b6b4819b80f0692243a41e36
https://doi.org/10.1073/pnas.252396199

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Aza-[3,3]-Claisen Enolate Rearrangement in Vinylaziridines: Stereoselective Synthesis of Mono-, Di-, and Trisubstituted Seven-Membered Lactams

Autor: Peter Somfai, Ulf M. Lindström

Publikováno v: Chemistry. 7:94-98

Several 2,3-disubstituted vinylaziridines have been N-acylated and subjected to LiHMDS in THF at - 78 degreesC. Upon warming to room temperature, the resulting amide enolates underwent a highly stereoselective [3,3]-sigmatropic rearrangement to give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::181c718c583c6d184b68b43428d85bd9
https://doi.org/10.1002/1521-3765(20010105)7:1<94::aid-chem94>3.0.co

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Total Synthesis of (+-)-Monomorine I and (+-)-Indolizidine 195B by an Aza-[2,3]-Wittig Rearrangement of a Vinylaziridine

Autor: Peter Somfai, Tomas Jarevång, Ulf M. Lindström, Anette Svensson, M. Hanfland, E. Dooryhee

Publikováno v: Acta Chemica Scandinavica. 51:1024-1029

A novel synthesis of (+/-)-monomorine I (1) and (+/-)-indolizidine 195B (2) is described in which the key step is the highly efficient aza-[2,3]-Wittig rearrangement of vinylaziridine 12 into tetrahydropyridine 13. Functional group manipulation then

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https://doi.org/10.3891/acta.chem.scand.51-1024

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An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs

Autor: Ulf M. Lindström, Eric T. Kool

Publikováno v: Nucleic acids research. 30(19)

A general problem that exists in the assembly of large and organized DNA structures from smaller fragments is secondary structure that blocks or prevents it. For example, it is common to assemble longer synthetic DNA and RNA fragments by ligation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750596d28549e98812e7656e3e8dd225
https://pubmed.ncbi.nlm.nih.gov/12364618

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