Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Ulf H. Dolling"'
Autor:
Robert D. Wilson, George Zhou, Antony J. Davies, Gavin W. Stewart, Karel M. J. Brands, David Hands, Steven F. Oliver, Michael S. Ashwood, Robert A. Reamer, Ed Cleator, Matthew M. Bio, Ulf-H. Dolling, Khateeta M. Emerson, Faye J. Sheen, Arlene E. Mckeown, Andrew D. Gibb
Publikováno v:
Organic Process Research & Development. 13:543-547
A practical and efficient synthesis of 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole, 1, is described. A new one-pot process has been developed, starting from the commercially availa...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189b5b874e3f609e10aad2d368739b31
https://doi.org/10.1021/op800290t
https://doi.org/10.1021/op800290t
Autor:
Ulf-H. Dolling, Khateeta M. Emerson, Adrian Goodyear, Debra J. Wallace, Karel M. J. Brands, Steven F. Oliver, Cameron J. Cowden, Sarah E. Brewer, Michael S. Ashwood, Gavin W. Stewart, Jeremy P. Scott, Andrew D. Gibb
Publikováno v:
Organic Process Research & Development. 12:723-730
A practical asymmetric synthesis of the estrogen receptor beta selective agonist (7β-9aβ)-1,4-dichloro-2-hydroxygibba-1(10a),2,4,4b-tetraen-6-one (1), proceeding by way of six isolated intermediates and without recourse to chromatography, is descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::641f65b83066cce07f158df0f2a6acc5
https://doi.org/10.1021/op700178q
https://doi.org/10.1021/op700178q
Autor:
Joseph F. Payack, Jeremy P. Scott, Antony J. Davies, Andrew D. Gibb, Michael Palucki, David R. Lieberman, Jimmy O. DaSilva, Ulf-H. Dolling, Deborah C. Hammond, Karel M. J. Brands, Sarah E. Brewer, Brian C. Bishop, Peter G. Dormer
Publikováno v:
The Journal of Organic Chemistry. 72:4864-4871
This paper describes a remarkably efficient process for the preparation of gamma-secretase inhibitor 1. The target is synthesized in only five steps with an overall yield of 58%. The key operation is a highly selective and practical, crystallization-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f773d0b27792d3c50460a9f264ff5363
https://doi.org/10.1021/jo0705925
https://doi.org/10.1021/jo0705925
Autor:
Ulf-H. Dolling, Antony J. Davies, K. M. Jos Brands, Matthew M. Bio, Faye J. Sheen, Ed Cleator
Publikováno v:
Tetrahedron Letters. 47:4245-4248
A novel and efficient synthesis of a range of racemic and enantioenriched N-substituted-4-substituted isothiazolidine-1,1-dioxides from epoxides and sulfonamides is described. The critical choice of the activating group for the cyclization event is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0161458aec1af8db82438fd5e34988
https://doi.org/10.1016/j.tetlet.2006.04.038
https://doi.org/10.1016/j.tetlet.2006.04.038
Publikováno v:
Organic Process Research & Development. 10:398-402
An expedient regioselective synthesis of a GABA α2/3 agonist 1 is described. The key step is an efficient regioselective palladium-catalyzed coupling of 7-trifluoromethylimidazo[1,2-a]pyrimidine (5) to 5‘-chloro-4,2‘-difluorobiphenyl-2-carbonitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6388c299b340f4a77a412d2e65d855fb
https://doi.org/10.1021/op050217j
https://doi.org/10.1021/op050217j
Autor:
Antony J. Davies, Karel M. J. Brands, Sarah E. Brewer, Robert D. Wilson, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Ulf-H. Dolling, David Hands, Stephen P. Keen, Robert A. Reamer, Steven F. Oliver
Publikováno v:
The Journal of Organic Chemistry. 71:3086-3092
A practical asymmetric synthesis of the gamma-secretase inhibitor (-)-1 is described. As the key transformation, a highly diastereoselective intramolecular nitrile oxide cycloaddition forms the hexahydrobenzisoxazole core of 3 in four operations. Oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f032407119fcad06ff980eed48c48c77
https://doi.org/10.1021/jo060033i
https://doi.org/10.1021/jo060033i
Autor:
Ulf-H. Dolling, Brenda Pipik, Yao-Jun Shi, James M. McNamara, George Zhou, Cameron J. Cowden, David A. Conlon, F. Conrad Engelhardt
Publikováno v:
The Journal of Organic Chemistry. 71:480-491
[reaction: see text] A newly developed synthesis of a NO-releasing prodrug of rofecoxib is described. The highly productive process consists of five chemical steps and produces prodrug 1 in an overall 64% yield from commercially available 3-phenyl-2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bddc982b39e079a60a046d1b0a09f55
https://doi.org/10.1021/jo051712g
https://doi.org/10.1021/jo051712g
Autor:
Ulf H. Dolling, Michael H. Kress, Shawn P. Allwein, Todd D. Nelson, Elizabeth A. Secord, Andrew Martins, Jeffrey V. Mitten
Publikováno v:
Synlett. 2004:2489-2492
A convenient route to 1-aminocyclopropane-1-carboxylic acid (1, ACC) and N-protected derivatives was developed. This route utilizes a bisalkylation of an O-benzyl glycine derived imine followed by global deprotection via hydrogenation. Direct isolati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbc32477803b9851fbedd73cb180796
https://doi.org/10.1055/s-2004-834793
https://doi.org/10.1055/s-2004-834793
Autor:
Ulf-H. Dolling, Karel M. J. Brands, Sarah E. Brewer, Deborah C. Hammond, Cameron J. Cowden, Antony J. Davies, Brian C. Bishop
Publikováno v:
Tetrahedron Letters. 45:6125-6128
An efficient method to prepare 3-substituted propionaldehyde derivatives using a Suzuki–Miyaura coupling is reported. The reaction has been demonstrated on a range of substrates including several where the Heck reaction with allyl alcohol failed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc5fb9885785bbb18a5f4ac2e9d36b7
https://doi.org/10.1016/j.tetlet.2004.06.053
https://doi.org/10.1016/j.tetlet.2004.06.053
Publikováno v:
Tetrahedron Letters. 45:1721-1724
The ortho-alkylation of Boc-protected aminopyridines with α,ω-dihaloalkanes followed by in situ cyclisation, resulted in the corresponding annulated pyridine derivatives in good to excellent yields. The effect of the alkylating and chelating agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6649287084f9fc4a040d755ac82bf838
https://doi.org/10.1016/j.tetlet.2003.12.096
https://doi.org/10.1016/j.tetlet.2003.12.096