Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ulf G. Eriksson"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 212-224 (2022)
Abstract Home‐based measures of lung function, inflammation, symptoms, and medication use are frequently collected in respiratory clinical trials. However, new statistical approaches are needed to make better use of the information contained in the
Externí odkaz:
https://doaj.org/article/e256a382204e4660b81f746e20072d89
Autor:
Joachim Almquist, Muhammad Waqas Sadiq, Ulf G. Eriksson, Tove Hegelund Myrbäck, Susanne Prothon, Jacob Leander
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 8, Pp 444-455 (2020)
AZD9567 is a potent and selective nonsteroidal oral glucocorticoid receptor modulator. It is developed as an anti‐inflammatory drug with improved safety profile compared with steroids like prednisolone. Throughout the clinical development of AZD956
Externí odkaz:
https://doaj.org/article/af7419d539c84e809928c515313afae5
Autor:
Zsolt Cselényi, Aurelija Jucaite, Cecilia Kristensson, Per Stenkrona, Pär Ewing, Andrea Varrone, Peter Johnström, Magnus Schou, Ana Vazquez-Romero, Mohammad Mahdi Moein, Martin Bolin, Jonathan Siikanen, Pär Grybäck, Bengt Larsson, Christer Halldin, Ken Grime, Ulf G. Eriksson, Lars Farde
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background The radioligand [11C]VC-002 was introduced in a small initial study long ago for imaging of muscarinic acetylcholine receptors (mAChRs) in human lungs using positron emission tomography (PET). The objectives of the present study i
Externí odkaz:
https://doaj.org/article/b57a1b395ada441a9bd3f59c5762420f
Autor:
Agnieszka Król, Robert Palmér, Virginie Rondeau, Stephen Rennard, Ulf G. Eriksson, Alexandra Jauhiainen
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Chronic obstructive pulmonary disease (COPD) clinical trials aimed at evaluating treatment effects on exacerbations often suffer from early discontinuations of randomized treatment. Treatment discontinuations imply a loss of infor
Externí odkaz:
https://doaj.org/article/d1eb06c5383c4c59a2507108f703fde3
Autor:
Susanne Prothon, Magnus Aurivillius, Ulrika Tehler, Ulf G Eriksson, Ajay Aggarwal, Yingxue Chen
Publikováno v:
Drug Design, Development and Therapy. 16:485-497
Susanne Prothon,1 Magnus Aurivillius,2 Ulrika Tehler,3 Ulf G Eriksson,1 Ajay Aggarwal,4 Yingxue Chen5 1Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden; 2Late Stage Dev
Autor:
Zsolt Cselényi, Aurelija Jucaite, Pär Ewing, Per Stenkrona, Cecilia Kristensson, Peter Johnström, Magnus Schou, Martin Bolin, Christer Halldin, Bengt Larsson, Ken Grime, Ulf G Eriksson, Lars Farde
Publikováno v:
Frontiers in Nuclear Medicine. 2
IntroductionMolecular imaging has not been used to support the development of drugs for the treatment of pulmonary disorders. The aim of the present translational study was to advance quantitative pulmonary PET imaging by demonstrating occupancy of t
Autor:
Zsolt Cselényi, Aurelija Jucaite, Pär Ewing, Per Stenkrona, Cecilia Kristensson, Peter Johnström, Magnus Schou, Martin Bolin, Christer Halldin, Bengt Larsson, Ken Grime, Ulf G Eriksson, Lars Farde
Purpose Molecular imaging has not been used to support the development of drugs for the treatment of pulmonary disorders. The aim of the present translational study was to advance quantitative pulmonary PET imaging by demonstrating occupancy of the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2feb5604fafcbf49f2c23efc43b398a
https://doi.org/10.21203/rs.3.rs-1336103/v2
https://doi.org/10.21203/rs.3.rs-1336103/v2
Autor:
Zsolt Cselényi, Aurelija Jucaite, Pär Ewing, Per Stenkrona, Cecilia Kristensson, Peter Johnström, Magnus Schou, Martin Bolin, Christer Halldin, Bengt Larsson, Ken Grime, Ulf G Eriksson, Lars Farde
BackgroundThe aim of the present translational PET study was to estimate occupancy of tiotropium at muscarinic acetylcholine receptors (mAChR) in the lungs in vivo. The relationship between the tiotropium exposure and receptor occupancy (RO) in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befe844d14c449eb02b1e1c8fc0f5bfc
https://doi.org/10.21203/rs.3.rs-1336103/v1
https://doi.org/10.21203/rs.3.rs-1336103/v1
Autor:
Mark J. Anderton, Anthony Johnson, Menelas N. Pangalos, Paul Morgan, David J. Nicholls, Stefan Platz, Ulf G. Eriksson, J. Carl Barrett, Jerome T. Mettetal, Ruth March, Mark Fidock, Dean G. Brown, James Matcham, Steve Rees, Michael A. Snowden, Simon Lennard, Bengt Hamrén
Publikováno v:
Nature Reviews Drug Discovery. 17:167-181
In 2011, AstraZeneca embarked on a major revision of its research and development (R&D) strategy with the aim of improving R&D productivity, which was below industry averages in 2005-2010. A cornerstone of the revised strategy was to focus decision-m
Autor:
Michael J. Chappell, Britt-Marie Fihn, Elin Boger, Neil D. Evans, Ulf G. Eriksson, Pär Ewing, Markus Fridén
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:279-287
Investigation of pharmacokinetic/pharmacodynamic (PK/PD) relationships for inhaled drugs is challenging because of the limited possibilities of measuring tissue exposure and target engagement in the lung. The aim of this study was to develop a method