Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ulf Ellervik"'
Publikováno v:
Antibiotics, Vol 9, Iss 1, p 10 (2019)
The opportunistic human fungal pathogen Candida albicans relies on cell morphological transitions to develop biofilm and invade the host. In the current study, we developed new regulatory molecules, which inhibit the morphological transition of C. al
Externí odkaz:
https://doaj.org/article/6d6f587a88b64e4fbc2d48b297fa8adf
Autor:
Tiago Bozzola, Mariafrancesca Scalise, Christer U. Larsson, Michael C. Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard E. Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C. J. Dobson, Cesare Indiveri, Jenny Schelin, Ulf J. Nilsson, Ulf Ellervik
Publikováno v:
ACS Chemical Biology. 17:1890-1900
Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0951ce620b881eadab452b43a333c6
https://doi.org/10.1021/acschembio.2c00321
https://doi.org/10.1021/acschembio.2c00321
Supplementary Figures 1-3, Methods from Attenuation of Tumor Growth by Formation of Antiproliferative Glycosaminoglycans Correlates with Low Acetylation of Histone H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90892dec8a0f01d846d197d8ff3c7de5
https://doi.org/10.1158/0008-5472.22387230.v1
https://doi.org/10.1158/0008-5472.22387230.v1
Publikováno v:
ChemMedChem. 17
In search for novel antibacterial compounds, bacterial sialic acid uptake inhibition represents a promising strategy. Sialic acid plays a critical role for growth and colonisation of several pathogenic bacteria, and its uptake inhibition in bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbab7fac83be3ffb20a645a71362a09e
https://doi.org/10.1002/cmdc.202200351
https://doi.org/10.1002/cmdc.202200351
Publikováno v:
RSC Advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::44e01aab63b9af0c8c515febd692e2e6
Autor:
Sophie Manner, Ulf Ellervik, Emil Tykesson, Roberto Mastio, Zackarias Söderlund, Gunilla Westergren-Thorsson, Daniel Willén
Publikováno v:
Bioconjugate Chemistry
We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5e3975e605e15126bfcbd7fc68be9c
https://pubmed.ncbi.nlm.nih.gov/34784477
https://pubmed.ncbi.nlm.nih.gov/34784477
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613979
Although glycosaminoglycans (GAGs) are known to be involved in a variety of physiological and pathological processes, knowledge about their expression by cells or tissues, the GAGome, is limited. Xylosides can be used to induce the formation of GAGs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07decf87921699eb43bc2e3c98165756
https://doi.org/10.1007/978-1-0716-1398-6_15
https://doi.org/10.1007/978-1-0716-1398-6_15
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613979
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the synthesis of two classes of glycosaminoglycans (GAG), i.e., heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS). GAG chains are linear polysaccharides of alternating hexuronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12bbe322128618acc95427e37c54d0b5
https://doi.org/10.1007/978-1-0716-1398-6_38
https://doi.org/10.1007/978-1-0716-1398-6_38
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2303
Although glycosaminoglycans (GAGs) are known to be involved in a variety of physiological and pathological processes, knowledge about their expression by cells or tissues, the GAGome, is limited. Xylosides can be used to induce the formation of GAGs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9009653d5c8462101842197d9dca15e
https://pubmed.ncbi.nlm.nih.gov/34626379
https://pubmed.ncbi.nlm.nih.gov/34626379
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2303
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the synthesis of two classes of glycosaminoglycans (GAG), i.e., heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS). GAG chains are linear polysaccharides of alternating hexuronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f34ff26f1afc904c575034b73474d8c
https://pubmed.ncbi.nlm.nih.gov/34626402
https://pubmed.ncbi.nlm.nih.gov/34626402