Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ulf, Sivars"'
Autor:
Celine Dumont, Ulf Sivars, Theresa Andreasson, Lina Odqvist, Johan Mattsson, Amy DeMicco, Katerina Pardali, Gustav Johansson, Linda Yrlid, Rhona J Cox, Frank Seeliger, Marie Larsson, Ulf Gehrmann, Andrew M Davis, Outi Vaarala
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0222548 (2020)
The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) regulates nuclear-factor-kappa-B (NF-κB) activation downstream of surface receptors with immunoreceptor tyrosine-based activation motifs (ITAMs), such as the
Externí odkaz:
https://doaj.org/article/909a9832246b47aa89504ff3e52d2647
Autor:
Ulf Sivars, Richard J. Lewis, Moya Caffrey, Leif Hultin, Antonio Llinas, Karin Gedda, Peter Hansen, Asim K. Ray, Ulf Andersson, Sara Lundqvist, Hiroki Wada, Lisa Jinton, Tina Jellesmark Jensen, Igor L. Shamovsky, Cristina Gardelli, Stina Sjödin, Nina Krutrök, Cooper Martin, Paul S. Jansson
Publikováno v:
Journal of Medicinal Chemistry. 63:9705-9730
Muscle atrophy and cachexia are common comorbidities among patients suffering from cancer, chronic obstructive pulmonary disease, and several other chronic diseases. The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef4b3e60aec1cb7e3e736df78d14446
https://doi.org/10.1021/acs.jmedchem.0c00828
https://doi.org/10.1021/acs.jmedchem.0c00828
Autor:
Kostas Karabelas, Ulf Andersson, Lisa Jinton, Ulf Sivars, Leif Hultin, Joakim Larsson, Cristina Gardelli, Brith Leidvik, Karin Gedda, Marie Rydén Landergren, Igor L. Shamovsky, Hiroki Wada, Kristina Stenvall, Asim K. Ray, Moya Caffrey, Hitesh J. Sanganee, Joakim Tholander, Antonio Llinas
Publikováno v:
Journal of Medicinal Chemistry. 61:5974-5987
Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease, and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2ef8b442ba38cfd78bb51d4c5db1df
https://doi.org/10.1021/acs.jmedchem.8b00322
https://doi.org/10.1021/acs.jmedchem.8b00322
Autor:
David Hargeaves, Elizabeth England, Robert M. Woods, Michael Fung, Caroline Colley, Paul Warrener, Liz Flavell, Sudharsan Sridharan, Judit E. Debreczeni, Jessica Bonnell, Claire Dobson, Jingying Zha, Bryan M. Edwards, Ling-Ling An, Laura Eghobamien, Ulf Sivars, Joanne Arnold, Jonathan Renshaw, Bojana Popovic, Kate F. Wickson, Tristan J. Vaughan, Trevor Wilkinson
Publikováno v:
mAbs
'mAbs ', vol: 10, pages: 104-117 (2018)
'mAbs ', vol: 10, pages: 104-117 (2018)
C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1 and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well defined, whereas C5a–C5aR2 receptor interactions are poorly understood. Here, we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3b26c96696e2eb620d74383a366038
http://europepmc.org/articles/PMC5800367
http://europepmc.org/articles/PMC5800367
Autor:
Outi Vaarala, Ulf Sivars, Rhona J. Cox, Gustav Johansson, Ulf Gehrmann, Amy DeMicco, Andrew M. Davis, Marie Larsson, Katerina Pardali, Lina Odqvist, Céline Dumont, Johan Mattsson, Theresa Andreasson, Linda Yrlid, Frank Seeliger
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0222548 (2020)
PLoS ONE
PLoS ONE
The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) regulates nuclear-factor-kappa-B (NF-κB) activation downstream of surface receptors with immunoreceptor tyrosine-based activation motifs (ITAMs), such as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7bf3b02db94fd102453a4199f8eb44
https://doi.org/10.1371/journal.pone.0222548
https://doi.org/10.1371/journal.pone.0222548
Autor:
Perry Matthew, Fredrik Edfeldt, Isabella Feierberg, Mattias Rohman, Johan Evenäs, Alison Ward, Jens Petersen, Ulf Sivars, Thomas Hansson, Lisa Wissler, Karin Svensson, Xiao-Hong Zhou, Frank Narjes, Matti Lepistö
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2496-2500
Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs. Here we describe the discovery of a novel class of indole inhibitors, identified through focused screening of 42,000 compounds and evaluated using a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988fa1de7d07f0fb2c45aebc4c722a4
https://doi.org/10.1016/j.bmcl.2015.04.065
https://doi.org/10.1016/j.bmcl.2015.04.065
Autor:
Ulf Sivars, Samuel Constant, Hui Zhang, Song Huang, Kinga Balogh Sivars, Ellinor Hornberg, Catherine J. Betts, Lena Brändén, Rosy Bonfante, Ian Robinson, Per M. Åberg
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 162(1)
Respiratory tract toxicity represents a significant cause of attrition of inhaled drug candidates targeting respiratory diseases. One of the key issues to allow early detection of respiratory toxicities is the lack of reliable and predictive in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab7b782fe6d2613e02861234f347473
https://pubmed.ncbi.nlm.nih.gov/29182718
https://pubmed.ncbi.nlm.nih.gov/29182718
Autor:
Ann-Kristin Englund, Cecilia Emanuelsson, Henrik Everberg, Peter Lipniunas, Magnus Jörntén-Karlsson, Ulf Sivars, Folke Tjerneld, Lars Haneskog, Cecilia Persson
Publikováno v:
Journal of Chromatography A. 1029:113-124
Pre-fractionation of a complex mixture of proteins increases the resolution in analytical separations of proteins from cells, tissues or organisms. Here we demonstrate a novel method for pre-fractionation of membrane proteins by a detergent-based aqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a1ff179342039a82be10e0093988eb
https://doi.org/10.1016/j.chroma.2003.12.016
https://doi.org/10.1016/j.chroma.2003.12.016
Autor:
Li Ding, Paul M. Sincock, Suzanne R. Pfeffer, Ulf Sivars, Sven Diederichs, Brian O'Connor, Ian G. Ganley, Jeffrey P. Krise
Publikováno v:
Traffic. 4:18-25
TIP47 (tail-interacting protein of 47 kDa) binds to the cytoplasmic domains of mannose 6-phosphate receptors and is required for their transport from endosomes to the trans-Golgi network in vitro and in living cells. TIP47 occurs in cytosol as an oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf49ee4f7fc8249d4f87622fa9f8d7a
https://doi.org/10.1034/j.1600-0854.2003.40104.x
https://doi.org/10.1034/j.1600-0854.2003.40104.x
Autor:
Folke Tjerneld, Ulf Sivars
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1474:133-146
Detergent/polymer aqueous two-phase systems are studied as a fast, mild and efficient general separation method for isolation of labile integral membrane proteins. Mechanisms for phase behaviour and protein partitioning of both membrane-bound and hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a30eaecca8b7d258eb1f75f373bd5c
https://doi.org/10.1016/s0304-4165(99)00208-1
https://doi.org/10.1016/s0304-4165(99)00208-1