Výsledky vyhledávání - "Ulf, Brockmeier"

Akademický článek

Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolism

Autor: Ayan Mohamud Yusuf, Mina Borbor, Tanja Hussner, Carolin Weghs, Britta Kaltwasser, Matthias Pillath-Eilers, Bernd Walkenfort, Richard Kolesnick, Erich Gulbins, Dirk M. Hermann, Ulf Brockmeier

Publikováno v: Cell Death and Disease, Vol 15, Iss 9, Pp 1-14 (2024)

Abstract Acid sphingomyelinase (ASM) inhibitors are widely used for the treatment of post-stroke depression. They promote neurological recovery in animal stroke models via neurorestorative effects. In a previous study, we found that antidepressants i

Externí odkaz: https://doaj.org/article/bb96a3a7cca44e52960359d37b31a205

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Akademický článek

In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway

Autor: Tobias Ocklenburg, Fabian Neumann, Alexandra Wolf, Julia Vogel, Kirsten Göpelt, Melanie Baumann, Jennifer Baumann, Philip Kranz, Eric Metzen, Ulf Brockmeier

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract The disulfide isomerase ERp57, originally found in the endoplasmic reticulum, is located in multiple cellular compartments, participates in diverse cell functions and interacts with a huge network of binding partners. It was recently suggest

Externí odkaz: https://doaj.org/article/70c99fc6b9384a9d8053fe7ddefd8962

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Akademický článek

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis

Autor: Alina Küper, Jennifer Baumann, Kirsten Göpelt, Melanie Baumann, Christopher Sänger, Eric Metzen, Philip Kranz, Ulf Brockmeier

Publikováno v: Cell Death and Disease, Vol 12, Iss 1, Pp 1-11 (2021)

Abstract Hypoxia-induced resistance of tumor cells to therapeutic treatment is an unresolved limitation due to poor vascular accessibility and protective cell adaptations provided by a network, including PERK, NRF2, and HIF signaling. All three pathw

Externí odkaz: https://doaj.org/article/b791e66bbfba41b79cde36f1dc44fca4

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Akademický článek

The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia

Autor: Mosche Pompsch, Julia Vogel, Fabian Classen, Philip Kranz, George Iliakis, Helena Riffkin, Ulf Brockmeier, Eric Metzen

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)

Abstract Background The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondrial DNA. Therefore MTH1

Externí odkaz: https://doaj.org/article/8b14a0f6eff5445e891288cc7a4323ad

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Neurotoxicity of ischemic astrocytes involves STAT3-mediated metabolic switching and depends on glycogen usage

Autor: Mina Borbor, Dongpei Yin, Ulf Brockmeier, Chen Wang, Marius Doeckel, Matthias Pillath‐Eilers, Britta Kaltwasser, Dirk M. Hermann, Egor Dzyubenko

Astrocytic responses are critical for the maintenance of neuronal networks in health and disease. In stroke, reactive astrocytes undergo functional changes potentially contributing to secondary neurodegeneration, but the mechanisms of astrocyte-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5a72cbf4cbf133f3b48096dc8ab8eb
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85148596173

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