Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

Autor: Hou, Jinchao, Zhou, Yingyue, Cai, Zhangying, Terekhova, Marina, Swain, Amanda, Andhey, Prabhakar S., Guimaraes, Rafaela M., Ulezko Antonova, Alina, Qiu, Tian, Sviben, Sanja, Strout, Gregory, Fitzpatrick, James A.J., Chen, Yun, Gilfillan, Susan, Kim, Do-Hyun, Van Dyken, Steven J., Artyomov, Maxim N., Colonna, Marco

Publikováno v: In Cell Reports 25 April 2023 42(4)

Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

Autor: Jinchao Hou, Yingyue Zhou, Zhangying Cai, Marina Terekhova, Amanda Swain, Prabhakar S. Andhey, Rafaela M. Guimaraes, Alina Ulezko Antonova, Tian Qiu, Sanja Sviben, Gregory Strout, James A.J. Fitzpatrick, Yun Chen, Susan Gilfillan, Do-Hyun Kim, Steven J. Van Dyken, Maxim N. Artyomov, Marco Colonna

Publikováno v: Cell Reports, Vol 42, Iss 4, Pp 112293- (2023)

Summary: Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is widely used to simulate demyelination and remyelination occurring in thes

Externí odkaz: https://doaj.org/article/88e9b8d402b7438ab8416cbd0fcc4c6a

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The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease.

Autor: Cao S; Division of Gastroenterology, Department of Medicine and.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA., Fachi JL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA., Ma K; Division of Gastroenterology, Department of Medicine and., Ulezko Antonova A; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA., Wang Q; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA., Cai Z; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA., Kaufman RJ; Degenerative Diseases Program, Center for Genetic Disorders and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Ciorba MA; Division of Gastroenterology, Department of Medicine and., Deepak P; Division of Gastroenterology, Department of Medicine and., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 09; Vol. 134 (13). Date of Electronic Publication: 2024 May 09.

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

Autor: Mingyu He, Kate Roussak, Feiyang Ma, Nicholas Borcherding, Vince Garin, Mike White, Charles Schutt, Trine I. Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Ulezko Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew M. Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert L. Modlin, Ryan C. Fields, Robert D. Schreiber, Paul M. Allen, Eynav Klechevsky

Publikováno v: He, M, Roussak, K, Ma, F, Borcherding, N, Garin, V, White, M, Schutt, C, Jensen, T I, Zhao, Y, Iberg, C A, Shah, K, Bhatia, H, Korenfeld, D, Dinkel, S, Gray, J, Ulezko Antonova, A, Ferris, S, Donermeyer, D, Lindestam Arlehamn, C, Gubin, M M, Luo, J, Gorvel, L, Pellegrini, M, Sette, A, Tung, T, Bak, R, Modlin, R L, Fields, R C, Schreiber, R D, Allen, P M & Klechevsky, E 2023, ' CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses ', Science, vol. 379, no. 6633, eabg2752 . https://doi.org/10.1126/science.abg2752

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph node

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb58f3075eb648887329399a6257400
https://pure.au.dk/portal/da/publications/cd5-expression-by-dendritic-cells-directs-t-cell-immunity-and-sustains-immunotherapy-responses(0a5862aa-3391-473b-9491-d06b9b57ccb2).html