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Akademický článek

Study of the anti-inflammatory, analgesic, ulcerogenic and anti-ulcerogenic activity of N-isopropenylimidazole zinc complex derivative

Autor: Pavel A. Galenko-Yaroshevsky, Olga V. Shelemekh, Viktor L. Popkov, Andrey V. Zadorozhniy, Irina B. Nektarevskaya, Natalia D. Bunyatyan, Roman A. Murashko, Svetlana A. Lebedeva, Anait V. Zelenskaya, Aleksandr V. Uvarov, Olga N. Gulevskaya, Lusine O. Alukhanyan, Tereza R. Glechyan, Alina V. Sergeeva, Alina V. Kornetskaya, Nikolay E. Korovaykin

Publikováno v: Research Results in Pharmacology, Vol 10, Iss 1, Pp 23-43 (2024)

Introduction: Although nonsteroidal anti-inflammatory drugs (NSAIDs) have a clear therapeutic benefit, they can also have serious side effects. The most serious of these is the ulcerogenic effect, which can result in a decline in the quality of life

Externí odkaz: https://doaj.org/article/20e84e18beac4a2cb8b2e31e37c12aaf

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Akademický článek

Antiulcer activity of ethanolic extract of Arctocarpus hirsutus Lam. leaves in albino Wistar rats

Autor: Chaithra B N, Ullas Prakash D’Souza, Prasanna Shama Khandige, Vandana Sadananda

Publikováno v: Journal of Applied Pharmaceutical Research, Vol 11, Iss 5, Pp 44-51 (2023)

Peptic ulcers, a prevalent gastrointestinal disorder, remain a significant health concern. Artocarpus hirsutus Lam., a plant deeply rooted in traditional medicine, has been historically employed to address various health issues. Each component of thi

Externí odkaz: https://doaj.org/article/0c72cfd2d5c249faadaecd751c48456c

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Akademický článek

Chemical Characterization and Pharmacological Evaluation of Phytophenols-Etodolac Mutual Prodrugs

Autor: Kamal Shah, Gaurav Krishna

Publikováno v: Iraqi Journal of Pharmaceutical Sciences, Vol 32, Iss 3 (2023)

Etodolac is choice of drug for pain and inflammation but has major side effects of gastric ulcers that are due to free carboxylic group. Etodolac belongs to the chemical class of non-selective COX-inhibitor but preferentially COX-2 inhibitor. Here th

Externí odkaz: https://doaj.org/article/b17d2a596f4044189617117b975c48c4

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Akademický článek

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

Autor: Najla A. Alshaye, Mohamed K. Elgohary, Mahmoud S. Elkotamy, Hatem A. Abdel-Aziz

Publikováno v: Molecules, Vol 29, Iss 6, p 1309 (2024)

COX-2 plays a key role in converting arachidonic acid into prostaglandins. This makes it a significant target for treating inflammation. Selective COX-2 inhibitors have marked a new phase in inflammatory treatment, providing significant effectiveness

Externí odkaz: https://doaj.org/article/8b93b751d6b44abcb8fbbe4378eafe3a

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Akademický článek

Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Autor: Abdelgawad MA, Al-Sanea MM, Musa A, Elmowafy M, El-Damasy AK, Azouz AA, Ghoneim MM, Bakr RR

Publikováno v: Journal of Inflammation Research, Vol Volume 15, Pp 451-463 (2022)

Mohamed A Abdelgawad,1 Mohammad M Al-Sanea,1 Arafa Musa,2 Mohammed Elmowafy,3 Ashraf K El-Damasy,4 Amany A Azouz,5 Mohammed M Ghoneim,6 Rania R Bakr7 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf, 7234

Externí odkaz: https://doaj.org/article/4ab2aeeb54f3482fa4da464477e8831f

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Akademický článek

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Akademický článek

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Akademický článek

Rational drug design, synthesis, and in vivo biological activity of new indolyl-imidazolone hybrids as potential and safer non-steroidal anti-inflammatory agents

Autor: Asif Husain, Abdullah F. AlAsmari, Syed Najmul Hejaz Azmi, Nemat Ali, Md Moklesur Rahman Sarker, Metab Alharbi, Mohd Ishtikhar, Shah Alam Khan

Publikováno v: Journal of King Saud University: Science, Vol 34, Iss 4, Pp 102023- (2022)

Objectives: The study aimed to synthesize and evaluate the potential anti-inflammatory and analgesic activities of rationally designed hybrid molecules of imidazolone and indole nuclei linked through a methylene bridge. Methods: Indolyl-imidazolone h

Externí odkaz: https://doaj.org/article/9953a4470cf84692af786fc50610e41e

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Akademický článek

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Akademický článek

Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile

Autor: Michelyne Haroun, Maria Fesatidou, Anthi Petrou, Christophe Tratrat, Panagiotis Zagaliotis, Antonis Gavalas, Katharigatta N. Venugopala, Hafedh Kochkar, Promise M. Emeka, Nancy S. Younis, Dalia Ahmed Elmaghraby, Mervt M. Almostafa, Muhammad Shahzad Chohan, Ioannis S. Vizirianakis, Aliki Papadimitriou-Tsantarliotou, Athina Geronikaki

Publikováno v: Molecules, Vol 28, Iss 8, p 3416 (2023)

Major obstacles faced by the use of nonsteroidal anti-inflammatory drugs (NSAID) are their gastrointestinal toxicity induced by non-selective inhibition of both cyclooxygenases (COX) 1 and 2 and their cardiotoxicity associated with a certain class of

Externí odkaz: https://doaj.org/article/18a59193f9924d31ac5c5a1b48fac4bf

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