Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ukjin Kim"'
Autor:
Ukjin Kim, Rahul Debnath, Javier E. Maiz, Joshua Rico, Satrajit Sinha, Mario Andrés Blanco, Rumela Chakrabarti
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109366- (2024)
Summary: Triple-negative breast cancer (TNBC) contributes greatly to mortality of breast cancer, demanding new targetable options. We have shown that TNBC patients have high ΔNp63 expression in tumors. However, the function of ΔNp63 in established
Externí odkaz:
https://doaj.org/article/e9fd99b79e7240e78aa30f8687498c0c
Autor:
Young-Hoon Jeong, Ukjin Kim, Seul-Gi Lee, Bokyeong Ryu, Jin Kim, Artyuhov Igor, Jong Soo Kim, Cho-Rok Jung, Jae-Hak Park, C-Yoon Kim
Publikováno v:
BMC Biotechnology, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Vitrification is the most promising technology for successful cryopreservation of living organisms without ice crystal formation. However, high concentrations (up to ~ 6–8 M) of cryoprotective agents (CPAs) used in stem cell ind
Externí odkaz:
https://doaj.org/article/97a31ba7db9a474488ee282c2fbc809d
Next-Generation Intestinal Toxicity Model of Human Embryonic Stem Cell-Derived Enterocyte-Like Cells
Autor:
Bokyeong Ryu, Mi-Young Son, Kwang Bo Jung, Ukjin Kim, Jin Kim, Ohman Kwon, Ye Seul Son, Cho-Rok Jung, Jae-Hak Park, C-Yoon Kim
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
The gastrointestinal tract is the most common exposure route of xenobiotics, and intestinal toxicity can result in systemic toxicity in most cases. It is important to develop intestinal toxicity assays mimicking the human system; thus, stem cells are
Externí odkaz:
https://doaj.org/article/2203e98e98fd415eac74a9e467ee6a44
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, co
Externí odkaz:
https://doaj.org/article/15f35341ba9a444ea1df9bcd005e45ec
Publikováno v:
Biochemical and Biophysical Research Communications. 621:151-156
The p53 tumor suppressor regulates cell functions either by acting as a transcription factor or by interacting with other proteins. Previously, we reported that the non-transcriptional actions of p53 can be facilitated by the binding of p53 to p21. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445691e5c24b9df6d7d31889183cf822
https://doi.org/10.1016/j.bbrc.2022.07.022
https://doi.org/10.1016/j.bbrc.2022.07.022
Publikováno v:
Biochemical and biophysical research communications. 635
Given our previous finding that certain tumor-suppressing functions of p53 are exerted by the p53/p21 complex, rather than p53 alone, cells may have a system to regulate the p53/p21 interaction. As p53 binds to p21 via its C-terminal domain, which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0befa085d5514b0cd6c259faef169e94
https://pubmed.ncbi.nlm.nih.gov/36257192
https://pubmed.ncbi.nlm.nih.gov/36257192
Publikováno v:
Biochemical and Biophysical Research Communications. 543:23-28
Downregulation of the p53 tumor suppressor in cancers is frequently accompanied by the upregulation of Wip1 (a phosphatase) and Mdm2 (an E3 ubiquitin ligase). Mdm2 binds and ubiquitinates p53, promoting its degradation by the proteasome. As the p53/M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d812af7c1434980b69a42c52ce9519c
https://doi.org/10.1016/j.bbrc.2021.01.074
https://doi.org/10.1016/j.bbrc.2021.01.074
Autor:
Ukjin Kim, Rumela Chakrabarti
Publikováno v:
Cancer Research. 83:323-323
BACKGROUND: Triple-negative breast cancer (TNBC) is highly malignant and has a poor prognosis because it lacks hormone therapy options. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), a major component in tumor microenvironment are kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0944a3f3413fe09b6b30ff4c92fa975f
https://doi.org/10.1158/1538-7445.am2023-323
https://doi.org/10.1158/1538-7445.am2023-323
Autor:
Jin Kim, Jae-Hak Park, Ukjin Kim, Takashi Yamamoto, Tetsushi Sakuma, Hyokyung Yang, Ji Min Lee, Bokyeong Ryu
Publikováno v:
The Prostate. 81:182-193
Background Recent developments in gene editing, using transcriptional activator-like effector nucleases (TALENs), have greatly helped the generation of genetically engineered animal models. The NK3 homeobox 1 (NKX3.1) protein plays important roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070846da8987b6b0f557a63ee4894179
https://doi.org/10.1002/pros.24095
https://doi.org/10.1002/pros.24095
Publikováno v:
BMB Reports
Several humanized mouse models are being used to study humanspecific immune responses and diseases. However, the pivotal needs of fetal tissues for the humanized mice model have been huddled because of the demand for ethical and medical approval. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f566ad2f80b56effe610417b712f83
https://doi.org/10.5483/bmbrep.2020.53.9.304
https://doi.org/10.5483/bmbrep.2020.53.9.304