Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Ukhyun Jo"'
Autor:
Liton Kumar Saha, Sourav Saha, Xi Yang, Shar-yin Naomi Huang, Yilun Sun, Ukhyun Jo, Yves Pommier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
This study provides evidence that human topoisomerase IIIα (TOP3A) is closely associated with active replisomes. The authors uncover TOP3A DNA cleavage complexes (TOP3Accs) repair mechanisms to ensure normal DNA replication and genome integrity.
Externí odkaz:
https://doaj.org/article/9d63d9cf54ec4c5eb9ecd3f0d8455716
Autor:
Lorinc S. Pongor, Camille Tlemsani, Fathi Elloumi, Yasuhiro Arakawa, Ukhyun Jo, Jacob M. Gross, Sara Mosavarpour, Sudhir Varma, Rahul K. Kollipara, Nitin Roper, Beverly A. Teicher, Mirit I. Aladjem, William Reinhold, Anish Thomas, John D. Minna, Jane E. Johnson, Yves Pommier
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105338- (2022)
Summary: DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor. We examined global DNA methylation beyond the generally used promoter areas in human small cell lung cancer (SCLC) and find that gene body methylatio
Externí odkaz:
https://doaj.org/article/a17e396cdddf482889e621906481c5ce
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103173- (2021)
Summary: Schlafen11 (SLFN11) is referred to as interferon (IFN)-inducible. Based on cancer genomic databases, we identified human acute myeloid and lymphoblastic leukemia cells with gain-of-function mutations in the Janus kinase (JAK) family as exhib
Externí odkaz:
https://doaj.org/article/8d911496bc5d4627b0a2353ed7b9a677
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
Autor:
Junko Murai, Hongliang Zhang, Lorinc Pongor, Sai-Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4137-4151.e6 (2020)
Summary: Schlafen 11 (SLFN11) was recently discovered as a cellular restriction factor against replication stress. Here, we show that SLFN11 increases chromatin accessibility genome wide, prominently at active promoters in response to replication str
Externí odkaz:
https://doaj.org/article/c7b01b99da8341dabfbc2cba59cb282c
Publikováno v:
Cancers, Vol 13, Iss 18, p 4601 (2021)
Precision medicine aims to implement strategies based on the molecular features of tumors and optimized drug delivery to improve cancer diagnosis and treatment. DNA replication is a logical approach because it can be targeted by a broad range of anti
Externí odkaz:
https://doaj.org/article/1e1c0aade84b45979337b53167704c25
Autor:
Jingming Wang, Bryan Chan, Michael Tong, YiTing Paung, Ukhyun Jo, Dwight Martin, Markus Seeliger, John Haley, Hyungjin Kim
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007983 (2019)
The Fanconi Anemia (FA) pathway is a multi-step DNA repair process at stalled replication forks in response to DNA interstrand cross-links (ICLs). Pathological mutation of key FA genes leads to the inherited disorder FA, characterized by progressive
Externí odkaz:
https://doaj.org/article/c3338ef888cd45aeb41e6e2bac3d7a8d
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006465 (2016)
Maintaining genomic integrity during DNA replication is essential for cellular survival and for preventing tumorigenesis. Proliferating cell nuclear antigen (PCNA) functions as a processivity factor for DNA replication, and posttranslational modifica
Externí odkaz:
https://doaj.org/article/3a91b183c88e4ae7962ba7a16541eb37
Autor:
Young Mi Whang, Ukhyun Jo, Jae Sook Sung, Hyun Jung Ju, Hyun Kyung Kim, Kyong Hwa Park, Jong Won Lee, In Song Koh, Yeul Hong Kim
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53012 (2013)
Wnt5a is overexpressed during the progression of human non-small cell lung cancer. However, the roles of Wnt5a during smoking-related lung carcinogenesis have not been clearly elucidated. We investigated the associations between Wnt5a and the early d
Externí odkaz:
https://doaj.org/article/c42cf90ad23a45fa9d4a8eaa968d9469
Autor:
Junko Murai, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier
Publikováno v:
Molecular Cancer Therapeutics.
SLFN11 is an increasingly prominent predictive biomarker and a molecular sensor for a wide range of clinical drugs: topoisomerases, PARP and replication inhibitors, and platinum derivatives. To expand the spectrum of drugs and pathways targeting SLFN
Autor:
Yves Pommier, Woo Suk Choi, Ranjit S. Bindra, Juan C. Vasquez, Jinny Van Doorn, Ranjini K. Sundaram, Vishwas Paralkar, Kelli Jones, Sophia Gayle, Yasuhiro Arakawa, Xi Yang, Liton Kumar Saha, Yilun Sun, Keli K. Agama, Yasuhisa Murai, Ukhyun Jo
Supplementary Figure from TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7dcb1d7bd78ba120f65eb7bbd6949b
https://doi.org/10.1158/1535-7163.22523397.v1
https://doi.org/10.1158/1535-7163.22523397.v1