Výsledky vyhledávání - "Ujjwal Ghosh"

Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro

Autor: Ujjwal Ghosh, Shalini Gupta, Surajit Sinha

Publikováno v: Bioconjugate Chemistry. 34:174-180

Thiol functionalized oligonucleotides are useful intermediates for a wide range of applications including DNA nanobiotechnology field through conjugation with various types of probes and cargos. Due to the limitation of synthetic process, phosphorodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f168f320a6f8aa83c2db77b0ba825ed8
https://doi.org/10.1021/acs.bioconjchem.2c00587

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Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer

Autor: Jayanta Kundu, Atanu Ghosh, Ujjwal Ghosh, Arnab Das, Dhriti Nagar, Sankha Pattanayak, Aurnab Ghose, Surajit Sinha

Publikováno v: The Journal of organic chemistry. 87(15)

Phosphorodiamidate morpholino oligonucleotides (PMOs) constitute 3 out of the 11 FDA-approved oligonucleotide-based drugs in the last 6 years. PMOs can effectively silence disease-causing genes and modify splicing. However, PMO synthesis has remained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1352f62ddc8c41fb8384ad0ed41419e8
https://pubmed.ncbi.nlm.nih.gov/35839125

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Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxol in MCF-7 Cells

Autor: Ujjwal Ghosh, Surajit Sinha, Jayanta Kundu, Priyanjalee Banerjee, Chandra Bose, Ujjal Das

Publikováno v: Bioconjugate Chemistry. 31:2367-2382

A nontoxic delivery vehicle is essential for the therapeutic applications of antisense phosphorodiamidate morpholino oligonucleotides (PMOs). Though guanidinium-rich or arginine-rich cellular transporter conjugated Vivo-PMO or PPMO has been developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fd26bfbc2cd49b08f5a684c8f4ca0e
https://doi.org/10.1021/acs.bioconjchem.0c00444

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Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry-A New Method Amenable to Automated Synthesizer

Autor: Aurnab Ghose, Surajit Sinha, Arnab Das, Jayanta Kundu, Dhriti Nagar, Atanu Ghosh, Ujjwal Ghosh

Phosphorodiamidatemorpholino oligonucleotides (PMO) are routinely used for gene silencing and the recently developed PMO-based drug “Exondys51” has highlighted the importance of PMO as excellent antisense reagents. However, the synthesis of PMO h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be73038d2487e7949ef3b85d722e103
https://doi.org/10.26434/chemrxiv.12765563

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Understanding the Distribution Pattern of Prospective Reservoir Facies: A Sequence Stratigraphic Approach for Integrated Characterization of the Tarapur Field; Cambay Basin, India

Autor: Sharad Dubey, Sutapa Bhadra, Chandramani Shrivastva, Deepender Singh Bora, M. Yusuf Farooqui, Ujjwal Ghosh, Sudipan Shasmal

Publikováno v: All Days.

The Cambay Basin in western onshore India has been on production for a long time and most of the easy-to-find reservoir facies are being exploited by different operators. However, the complex setting of the basin provides opportunity for exploration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57139d56fba595fa87d3dca70f08a43b
https://doi.org/10.2118/129122-ms

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