Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ujjaldeep Jaggi"'
Autor:
Deepak Arya, Ujjaldeep Jaggi, Shaohui Wang, Kati Tormanen, Mingtian Che, Simeon Mahov, Ling Jin, Homayon Ghiasi
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Periodic reactivation of herpes simplex virus type 1 (HSV-1) triggers immune responses that result in corneal scarring (CS), known as herpes stromal keratitis (HSK). Despite considerable research, fully understanding HSK and eliminating it r
Externí odkaz:
https://doaj.org/article/bce174966a804717818a1652216015c4
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012307 (2024)
Multiple functions are associated with HSV-1 latency associated transcript (LAT), including establishment of latency, virus reactivation, and antiapoptotic activity. LAT encodes two sncRNAs that are not miRNAs and previously it was shown that they ha
Externí odkaz:
https://doaj.org/article/948b88a9c3dc41f092a4b01008ba854e
Autor:
Ujjaldeep Jaggi, Homayon Ghiasi
Publikováno v:
Viruses, Vol 16, Iss 9, p 1379 (2024)
CD80 is the best-known costimulatory molecule for effective T cell functions. Many different reports have summarized the role of CD80 in HSV-1 and its functions in maintaining adaptive immunity, which is the main player in causing herpes stromal kera
Externí odkaz:
https://doaj.org/article/504f37b955a74cbe96a2362b81b4959b
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011693 (2023)
Previously we reported that the HSV-1 latency associated transcript (LAT) specifically upregulates the cellular herpesvirus entry mediator (HVEM) but no other known HSV-1 receptors. HSV-1 glycoprotein D (gD) binds to HVEM but the effect of this inter
Externí odkaz:
https://doaj.org/article/443af00389944eb5ab295bbcb1bacbd9
Autor:
Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner. Since TH17 cells have been implicated in CNS pathology, in the present study, we
Externí odkaz:
https://doaj.org/article/6dec023a402c4ed3b35b88e5581101fd
Publikováno v:
mSphere, Vol 7, Iss 5 (2022)
ABSTRACT Over the past 70 years, multiple approaches to develop a prophylactic or therapeutic vaccine to control herpes simplex virus (HSV) infection have failed to protect against primary infection, reactivation, or reinfection. In contrast to many
Externí odkaz:
https://doaj.org/article/8ec1f841af3447e8ad8510eb9350fae4
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010898 (2022)
We previously reported that knocking out signal peptide peptidase (SPP), a glycoprotein K (gK) binding partner, in mouse peripheral sensory neurons reduced latency-reactivation in infected mice without affecting primary virus replication or eye disea
Externí odkaz:
https://doaj.org/article/9661bdee9f5e40d68d26e4e24d340fc7
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010281 (2022)
We previously reported that HSV-1 infectivity in vitro and in vivo requires HSV glycoprotein K (gK) binding to the ER signal peptide peptidase (SPP). Anterograde-retrograde transport via peripheral nerves between the site of infection (i.e., eye) and
Externí odkaz:
https://doaj.org/article/7c4df2d3c62e41e48873889c32d9b4ec
Autor:
Ujjaldeep Jaggi, Harry H Matundan, Jack Yu, Satoshi Hirose, Mathias Mueller, Floyd L Wormley, Homayon Ghiasi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009999 (2021)
Ocular HSV-1 infection is a major cause of eye disease and innate and adaptive immunity both play a role in protection and pathology associated with ocular infection. Previously we have shown that M1-type macrophages are the major and earliest infilt
Externí odkaz:
https://doaj.org/article/fc977b80a51a4b22958b32729e59586c
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression in vitro and in vivo. Similar to ICP22, the cellular costimulatory molecules CD28, CTLA4, and PD-L1 also bind to CD80. In this stud
Externí odkaz:
https://doaj.org/article/9776df8d282c476986c1363b6893cbc8