Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and In Silico ADMET screening

Autor: Monique Araújo de Brito, Pablo E. Perotto, Maicon Sarda, Ariane S. S. R. Ferreira, Patrícia R. Palm, Clodoaldo Machado, Ricardo José Nunes, Márcia Maria de Souza, Sabrina Cezar, Carlos Rangel Rodrigues, Kely Navakoski de Oliveira, Plínio Cunha Sathler, Lucio Mendes Cabral, Uiaran O. Magalhães, Helena Carla Castro

Publikováno v: Archives of Pharmacal Research. 35:1713-1722

In this paper, we describe the antinociceptive activity, molecular modeling and in silico ADMET screening of a series of sulphonyl-hydrazone and sulphonamide imidobenzene derivatives. Among these compounds, the sulphonyl-hydrazones 9 and 11 showed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbb68cfc8286fa032f91b0118ebdd27
https://doi.org/10.1007/s12272-012-1002-1

Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity

Autor: Carla Regina Andrighetti-Fröhner, Daniela Gaspar-Silva, Uiaran O. Magalhães, Antonio Carlos Joussef, Helena Carla Castro, Mário Steindel, Letícia Kramer Pacheco, Ricardo José Nunes, Ilídio F. Afonso, Kely Navakoski de Oliveira, Alessandra Mendonça Teles de Souza, Cláudia Maria Oliveira Simões, Carlos Rangel Rodrigues

Publikováno v: European Journal of Medicinal Chemistry. 44:755-763

Despite clinical importance of leishmaniasis, an infectious disease that affects 12 thousand million people in 88 countries, the treatment is still unsatisfactory due to its limited efficacy, cost expensive and undesirable side effects. Aiming to dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696c88a9e1ce8d52f8bcc1a4b6349d7c
https://doi.org/10.1016/j.ejmech.2008.04.016

Rational use of antioxidants in solid oral pharmaceutical preparations

Autor: Maísa Teodoro Celestino, Viviane de Oliveira Freitas Lione, Aline Guerra Manssour Fraga, Flávia Almada do Carmo, Lucio Mendes Cabral, Carlos Rangel Rodrigues, Uiaran O. Magalhães, Helena Carla Castro, Valeria Pereira de Sousa

Publikováno v: Brazilian Journal of Pharmaceutical Sciences; Vol. 48 No. 3 (2012); 405-415
Brazilian Journal of Pharmaceutical Sciences; Vol. 48 Núm. 3 (2012); 405-415
Brazilian Journal of Pharmaceutical Sciences; v. 48 n. 3 (2012); 405-415
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 48, Iss 3, Pp 405-415 (2012)
Brazilian Journal of Pharmaceutical Sciences, Volume: 48, Issue: 3, Pages: 405-415, Published: SEP 2012

Antioxidants are currently used as efficient excipients that delay or inhibit the oxidation process of molecules. Excipients are often associated with adverse reactions. Stability studies can guide the search for solutions that minimize or delay the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddb38f82fec7b7fdde52a65a2275093
https://www.revistas.usp.br/bjps/article/view/47854