Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ui S. Lee"'
Autor:
Edward J. Bertaccini, Madeline A. Cullins, James R. Trudell, Ui S. Lee, R. Adron Harris, Carlos I. Ruiz, Cecilia M. Borghese
Publikováno v:
ACS Chemical Neuroscience. 7:100-108
Alcohols inhibit γ-aminobutyric acid type A ρ1 receptor function. After introducing mutations in several positions of the second transmembrane helix in ρ1, we studied the effects of ethanol and hexanol on GABA responses using two-electrode voltage
Autor:
Stephanie A. Heusser, Torben Broemstrup, Ui S. Lee, Cecilia M. Borghese, Rebecca J. Howard, Erik Lindahl, R. Adron Harris, Madeline A. Cullins, Jens Carlsson
GABA(A) receptors play a crucial role in the actions of general anesthetics. The recently published crystal structure of the general anesthetic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of GABA(A) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349137e3ae51e3e1b8e71ac7991fef43
https://europepmc.org/articles/PMC3807073/
https://europepmc.org/articles/PMC3807073/
Autor:
P.J. Corringer, Marc Delarue, Ui S. Lee, Laurie Malherbe, Ludovic Sauguet, R. Adron Harris, Rebecca J. Howard
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2013, 4, pp.1697. ⟨10.1038/ncomms2682⟩
Nature Communications, 2013, 4, pp.1697. ⟨10.1038/ncomms2682⟩
Nature Communications, Nature Publishing Group, 2013, 4, pp.1697. ⟨10.1038/ncomms2682⟩
Nature Communications, 2013, 4, pp.1697. ⟨10.1038/ncomms2682⟩
International audience; Ethanol alters nerve signalling by interacting with proteins in the central nervous system, particularly pentameric ligand-gated ion channels. A recent series of mutagenesis experiments on Gloeobacter violaceus ligand-gated io
Autor:
Marc Delarue, Rebecca J. Howard, Ui S. Lee, Pierre-Jean Corringer, Laurie Malherbe, R. Adron Harris, Ludovic Sauguet
Publikováno v:
Biophysical Journal. 104(2)
Alcohol consumption produces a variety of undesirable behavioural and physiological effects in animals and humans and can eventually lead to addiction. Converging evidences suggest that its molecular mechanisms of action involve specific protein targ
Autor:
James R. Trudell, Cecilia M. Borghese, Edward J. Bertaccini, Carlos I. Ruiz, R. Adron Harris, Madeline A. Cullins, Ui S. Lee
Publikováno v:
Biophysical Journal. 110:428a
We examined why alcohols inhibit the γ-aminobutyric acid type A rho1 receptor (GABAaRrho1) function whereas alcohols potentiate other GABAaR subtypes. We did so by introducing mutations in the second transmembrane helix in GABAaRrho1. Homology model
Autor:
Samuel Murail, James R. Trudell, Pierre-Jean Corringer, Erik Lindahl, Marc Delarue, Suzzane Horani, R. Adron Harris, Ludovic Sauguet, Ui S. Lee, Rebecca J. Howard, Torben Broemstrup
Publikováno v:
Biophysical Journal. (2):635a-636a
Alcohol and Anesthetic Binding to Pentameric Ligand-Gated Ion Channels Revealed in a Prokaryotic Model System