Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Uhn-Soo Cho"'
Autor:
Young-Tae Lee, Alex Ayoub, Sang-Ho Park, Liang Sha, Jing Xu, Fengbiao Mao, Wei Zheng, Yang Zhang, Uhn-Soo Cho, Yali Dou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Regulation of the MLL family of histone H3K4 methyltransferases on the nucleosome core particle (NCP) remains largely unknown. Here the authors show that intrinsically disordered regions of ASH2L and DPY30 restrict the rotational dynamics of MLL1 on
Externí odkaz:
https://doaj.org/article/579dbc95fb704acb953fca9b4d33ed4c
Autor:
Sang Ho Park, Alex Ayoub, Young-Tae Lee, Jing Xu, Hanseong Kim, Wei Zheng, Biao Zhang, Liang Sha, Sojin An, Yang Zhang, Michael A. Cianfrocco, Min Su, Yali Dou, Uhn-Soo Cho
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
MLL family histone methyltransferases deposit histone H3 Lys4 mono-/di-/tri-methylation and regulate gene expression in mammals. Here the authors report the single-particle cryo-EM structure of the NCP-bound human MLL1 core complex, shedding light on
Externí odkaz:
https://doaj.org/article/dd454636ec51441b92111ea64c0ddfb1
Autor:
Gulzhan Raiymbek, Sojin An, Nidhi Khurana, Saarang Gopinath, Ajay Larkin, Saikat Biswas, Raymond C Trievel, Uhn-soo Cho, Kaushik Ragunathan
Publikováno v:
eLife, Vol 9 (2020)
H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigene
Externí odkaz:
https://doaj.org/article/b1c381fbb82045339d4db80a961b33fa
Autor:
Sang Ho Park, Alex Ayoub, Young-Tae Lee, Jing Xu, Hanseong Kim, Wei Zheng, Biao Zhang, Liang Sha, Sojin An, Yang Zhang, Michael A. Cianfrocco, Min Su, Yali Dou, Uhn-Soo Cho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/cb4d8adf8466474c94150c5a04afa3e2
Publikováno v:
eLife, Vol 6 (2017)
Kap123, a major karyopherin protein of budding yeast, recognizes the nuclear localization signals (NLSs) of cytoplasmic histones H3 and H4 and translocates them into the nucleus during DNA replication. Mechanistic questions include H3- and H4-NLS red
Externí odkaz:
https://doaj.org/article/39ff5bae9c674e70ab80c778687e3726
Autor:
Jae Wan Kim, Gyoo Cheon Kim, Ho Kyung Kim, John E. Foster, Uhn Soo Cho, Se Eun Yun, Hae June Lee
Publikováno v:
Applied Science and Convergence Technology. 31:19-22
Autor:
Eungjin Ahn, Byungchul Kim, Soyoung Park, Amanda L. Erwin, Suk Hyun Sung, Robert Hovden, Shyamal Mosalaganti, Uhn-Soo Cho
Cryogenic electron microscopy (cryo-EM) has become a widely used tool for determining protein structure. Despite recent technology advances, sample preparation remains a major bottleneck for several reasons, including protein denaturation at the air/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a698019009746c6845b94dfa884579ca
https://doi.org/10.1101/2021.12.26.474209
https://doi.org/10.1101/2021.12.26.474209
Publikováno v:
Biochemistry. 61(1)
Cryo-EM structures of the KMT2A/MLL1 core complex bound on nucleosome core particles (NCPs) suggest unusual rotational dynamics of the MLL1 complex approaching its physiological substrate. However, the functional implication of such dynamics remains
Autor:
Yali Dou, Wei Zheng, Young Tae Lee, Yang Zhang, Liang Sha, Sang Ho Park, Alex Ayoub, Jing Xu, Fengbiao Mao, Uhn-Soo Cho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Recent cryo-EM structures show the highly dynamic nature of the MLL1-NCP (nucleosome core particle) interaction. Functional implication and regulation of such dynamics remain unclear. Here we show that DPY30 and the intrinsically disordered regions (
Atmospheric pressure plasmas have been widely applied in surface modification and biomedical treatment due to its ability to generate highly reactive radicals and charged particles. In negative-stain electron microscopy (Neg-EM) and cryogenic electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05adb5ba122c344271348d6add6ff957
https://doi.org/10.1101/2021.05.11.443639
https://doi.org/10.1101/2021.05.11.443639