Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Uhlenbeck, O."'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1982 Dec 01. 79(23), 7127-7131.
Externí odkaz:
https://www.jstor.org/stable/13039
The role of individual functional groups on cytidine 17 in the hammerhead ribozyme was assessed by introducing modified pyrimidines into two kinetically well-characterized hammerheads. As long as the pyrimide ring size was maintained, the modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ace92e5f453fb9eda8685f337bf3748
https://europepmc.org/articles/PMC1369555/
https://europepmc.org/articles/PMC1369555/
The thermodynamic contribution of a stacking interaction between Tyr85 in MS2 coat protein and a single-stranded pyrimidine in its RNA binding site has been examined. Mutation of Tyr85 to Phe, His, Cys, Ser and Ala decreased the RNA affinity by 1-3 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::481ec5974084551a67a41c2e4dbc355a
https://europepmc.org/articles/PMC452510/
https://europepmc.org/articles/PMC452510/
To be effective in gene inactivation, the hammerhead ribozyme must cleave a complementary RNA target without deleterious effects from cleaving non-target RNAs that contain mismatches and shorter stretches of complementarity. The specificity of hammer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbdf054dfd94427898dc4af1f95262cd
https://europepmc.org/articles/PMC452045/
https://europepmc.org/articles/PMC452045/
Autor:
Clouet-D'Orval, B, Uhlenbeck, O C
Five new hammerhead ribozymes were designed that assemble through the formation of helices I and II (I/II format) instead of the more standard assembly through helices I and III (I/III format). The substrate binding and cleavage properties of such ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66f92d81ee3ceb78a980550716a9b47a
https://europepmc.org/articles/PMC1369389/
https://europepmc.org/articles/PMC1369389/
A series of antibiotics was tested for stimulation or inhibition of the hammerhead ribozyme cleavage reaction. Neomycin was found to be a potent inhibitor of the reaction with a Kl of 13.5 microM. Two hammerheads with well-characterized kinetics were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a694d2c45339be0009be9e690c3f895b
https://europepmc.org/articles/PMC1369065/
https://europepmc.org/articles/PMC1369065/
Publikováno v:
Annual Review of Biochemistry; Jul1995, Vol. 64 Issue 1, p763-797, 35p
Publikováno v:
Biopolymers; Jun1973, Vol. 12 Issue 6, p1313-1335, 23p
Autor:
Blount, K. F., Uhlenbeck, O. C.
Publikováno v:
Biochemical Society Transactions; November 2002, Vol. 30 Issue: 6 p1119-1122, 4p