Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Uh-Hyun Kim"'
Autor:
So-Young Rah, Yeonsoo Joe, Jeongmin Park, Stefan W. Ryter, Chansu Park, Hun Taeg Chung, Uh-Hyun Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 7, Pp 1492-1505 (2023)
Abstract Hepatic glucose production by glucagon is crucial for glucose homeostasis during fasting, yet the underlying mechanisms remain incompletely delineated. Although CD38 has been detected in the nucleus, its function in this compartment is unkno
Externí odkaz:
https://doaj.org/article/b2d86bd2e6ed4d5f82c454d911976f00
Publikováno v:
BioImpacts, Vol 14, Iss 2, Pp 27780-27780 (2024)
Introduction: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP). Here, we aimed to demonstrate the role of CD38 in platelets via protein kinase
Externí odkaz:
https://doaj.org/article/a322f2d1ba8a4c3d80bc519e92ec9456
Autor:
Mazhar Mushtaq, Uh-Hyun Kim
Publikováno v:
Biochemistry Research International, Vol 2020 (2020)
Background and Objectives. The primary function of platelets is to prevent bleeding. The use of UV-C light in the treatment of platelets has become a valuable method for preserving the efficacy of platelet concentrates in blood banks. However, its de
Externí odkaz:
https://doaj.org/article/700b1dd4dad243e0919e399f0fa33ae5
Autor:
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So-Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye-Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh-Hyun Kim, Hun Taeg Chung
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1063-1076.e5 (2020)
Summary: The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During
Externí odkaz:
https://doaj.org/article/46fa3d7af5bb4f3495587b6b55300ef1
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 2011-2034 (2018)
Background/Aims: Eggs of all animal species display intense cytoplasmic Ca2+ increases at fertilization. Previously, we reported that unfertilized eggs of Astropecten aranciacus exposed to an actin drug latrunculin A (LAT-A) exhibit similar Ca2+ wave
Externí odkaz:
https://doaj.org/article/8e8ea119680c4341ae00905fbda6021d
Publikováno v:
Cellular Physiology and Biochemistry, Vol 46, Iss 5, Pp 2017-2030 (2018)
Background/Aims: Cyclic ADP-ribose (cADPR) is a Ca2+ -mobilization messenger that acts on ryanodine-sensitive Ca2+ channels in the sarcoplasmic reticulum (SR) Ca2+ stores. Moreover, it has been proposed that cADPR serves an additional role in activat
Externí odkaz:
https://doaj.org/article/e0cf418e00e84b59bfaedb28a42e8e8c
Autor:
Eun-Kyung Song, Young-Rae Lee, Yu-Ri Kim, Ji-Hyun Yeom, Chae-Hwa Yoo, Hyun-Kag Kim, Hye-Min Park, Hyung-Sub Kang, Jong-Suk Kim, Uh-Hyun Kim, Myung-Kwan Han
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1607-1619 (2012)
Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation,
Externí odkaz:
https://doaj.org/article/8b78e629e32e4fa580929c4d37921f9a
Autor:
Rukhsana Gul, Dae-Ryoung Park, Asif Iqbal Shawl, Soo-Yeul Im, Tae-Sik Nam, Sun-Hwa Lee, Jae-Ki Ko, Kyu Yoon Jang, Donghee Kim, Uh-Hyun Kim
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149125 (2016)
Ca2+ signaling plays a fundamental role in cardiac hypertrophic remodeling, but the underlying mechanisms remain poorly understood. We investigated the role of Ca2+-mobilizing second messengers, NAADP and cADPR, in the cardiac hypertrophy induced by
Externí odkaz:
https://doaj.org/article/d90f7923732c48f59d83bf15d4d2a0c8
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134962 (2015)
Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca2+-mobilizing second messenger, cyclic ADP-ribose (cADPR). Here we show that a hybrid compound, arginine thi
Externí odkaz:
https://doaj.org/article/db99b5233845440bba42ea91b676bf7d
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139110 (2015)
Human sperm have to undergo a maturational process called capacitation in the female reproductive tract. Capacitation confers upon the sperm an ability to gain hypermotility and undergo acrosome reaction. Previous studies have suggested that seminal
Externí odkaz:
https://doaj.org/article/df9c362efc814ad784a4df824b032f6e