Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ugur Eskiocak"'
Autor:
Zhen Liu, Wilson Guzman, Parker Johnson, Megan McLaughlin, Caitlin O’Toole, Magali Pederzoli-Ribeil, Huawei Qiu, Margaret Karow, Tim Clackson, Jennifer O’Neil, Ugur Eskiocak, Miso Park, Benjamin Nicholson, John C Williams, Kurt A Jenkins, Deborah Moore-Lai, Veronica Flesch, Ronan C O’Hagan, Ulrich Rodeck
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Introduction The clinical benefit of the anti-CTLA-4 monoclonal antibody (mAb) ipilimumab has been well established but limited by immune-related adverse events, especially when ipilimumab is used in combination with anti-PD-(L)1 mAb therapy. To over
Externí odkaz:
https://doaj.org/article/d160ab0121654c39a0d99d2106b97ef4
Autor:
Wilson Guzman, Minjie Zhang, Parker Johnson, Megan McLaughlin, Kurt Jenkins, Hsin-Jung Wu, Hanumantha Rao Madala, Caitlin O’Toole, Magali Pederzoli-Ribeil, Raphael Rozenfeld, Huawei Qiu, Margaret Karow, Tim Clackson, Ronan O’Hagan, Jennifer O’Neil, Ugur Eskiocak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/3724762c0d9f4cefad90ea99d2af8b60
Autor:
John Williams, Wilson Guzman, Minjie Zhang, Parker Johnson, Megan McLaughlin, Kurt Jenkins, Caitlin O’Toole, Magali Pederzoli-Ribeil, Margaret Karow, Ronan O’Hagan, Jennifer O’Neil, Ugur Eskiocak, Miso Park, Timothy Clackson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/18e9ab13e46f4ab3b5a2d53faa893245
Autor:
Xiaofei Gao, Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang, Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara G.M. Piccirillo, Ugur Eskiocak, Digant P. Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, Wenzhi Sun, Robert M. Bachoo, Woo-ping Ge
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2489-2500.e5 (2020)
Summary: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. C
Externí odkaz:
https://doaj.org/article/bbf1b45e59a14c7fa609bc4ef41b8bc0
Autor:
Arthur E. Frankel, Ugur Eskiocak, Jennifer G. Gill, Stacy Yuan, Vijayashree Ramesh, Thomas W. Froehlich, Chul Ahn, Sean J. Morrison
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 4, Pp 255-260 (2017)
This is the first prospective study of a combination therapy involving a cardenolide and a MEK inhibitor for metastatic melanoma. Whereas BRAF mutant melanomas can exhibit profound responses to treatment with BRAF and MEK inhibitors, there are fewer
Externí odkaz:
https://doaj.org/article/c6ef23590d4242b2a6c0d804b3482a41
Autor:
Harish Potu, Luke F. Peterson, Malathi Kandarpa, Anupama Pal, Hanshi Sun, Alison Durham, Paul W. Harms, Peter C. Hollenhorst, Ugur Eskiocak, Moshe Talpaz, Nicholas J. Donato
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts
Externí odkaz:
https://doaj.org/article/e602171c7095415dab7480a2914dff72
Autor:
Stacy Y. Kasitinon, Ugur Eskiocak, Misty Martin, Divya Bezwada, Vishal Khivansara, Alpaslan Tasdogan, Zhiyu Zhao, Thomas Mathews, Arin B. Aurora, Sean J. Morrison
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2293-2305.e9 (2019)
Summary: We screen ion channels and transporters throughout the genome to identify those required by human melanoma cells but not by normal human melanocytes. We discover that Mucolipin-1 (MCOLN1), which encodes the lysosomal cation channel TRPML1, i
Externí odkaz:
https://doaj.org/article/167bcf5cf7ce4415b1b79af20d367b01
Autor:
Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E. Frankel, Timothy M. Johnson, Ralph J. DeBerardinis, Sean J. Morrison
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calc
Externí odkaz:
https://doaj.org/article/af2b613ebe124fc991b554202905400b
Autor:
Peter Ly, Ugur Eskiocak, Sang B. Kim, Andres I. Roig, Suzie K. Hight, Dypti R. Lulla, Ying S. Zou, Kimberly Batten, Woodring E. Wright, Jerry W. Shay
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 4, Pp 348-357 (2011)
Chromosomal instability leading to aneuploidy occurs in most sporadic colorectal cancers (CRCs) and is believed to be an early driving force in disease progression. Despite this observation, the cellular advantages conferred by these cytogenetic alte
Externí odkaz:
https://doaj.org/article/c684211bc5fe41269fc99a3ff9c33987
Autor:
Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E. Frankel, Timothy M. Johnson, Ralph J. DeBerardinis, Sean J. Morrison
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7 Article number:12336 (2016); Published 22 August 2016; Updated 29 September 2016 Arthur E. Frankel, who helped to interpret the clinical relevance of the findings, was inadvertently omitted from the authors list during the fin
Externí odkaz:
https://doaj.org/article/a457b2620e964011be0bf95dd1a7332b