Zobrazeno 1 - 10
of 618
pro vyhledávání: '"Ugur, Sahin"'
Autor:
Luisa Bresadola, David Weber, Christoph Ritzel, Martin Löwer, Valesca Bukur, Özlem Akilli-Öztürk, Christian Schuster, Alessandra Gargano, Julia Becker, Hisham Mehanna, Barbara Schrörs, Fulvia Vascotto, Ugur Sahin, Anthony Kong
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract Background Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous in terms of origin and aetiology. In addition, there is uncertainty about the genetic evolution from initial diagnosis to recurrence after primary treatments and fu
Externí odkaz:
https://doaj.org/article/ca00f57f17a34a7da41ab466171b8575
Autor:
Alexander Muik, Jasmin Quandt, Bonny Gaby Lui, Maren Bacher, Sebastian Lutz, Maika Grünenthal, Aras Toker, Jessica Grosser, Orkun Ozhelvaci, Olga Blokhina, Svetlana Shpyro, Isabel Vogler, Nadine Salisch, Özlem Türeci, Ugur Sahin
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114567- (2024)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure histories become increasingly complex through original and variant-adapted vaccines and infections with viral variants. Upon exposure to the highly altered Omicron spike g
Externí odkaz:
https://doaj.org/article/6d3ec055e6634edda15eec6aea826f60
Autor:
Ayşegül Yıldız, Aida Hasani, Tina Hempel, Nina Köhl, Aline Beicht, René Becker, Stefanie Hubich-Rau, Martin Suchan, Marco A. Poleganov, Ugur Sahin, Tim Beissert
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102162- (2024)
The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and trans-amplif
Externí odkaz:
https://doaj.org/article/8d3f6bfef2ca43eca17d626631e56ca1
Autor:
Thomas Ziegenhals, Ronja Frieling, Philipp Wolf, Katharina Göbel, Stina Koch, Mia Lohmann, Markus Baiersdörfer, Stephanie Fesser, Ugur Sahin, Andreas N. Kuhn
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Exogeneous messenger ribonucleic acid (mRNA) can be used as therapeutic and preventive medication. However, during the enzymatic production process, commonly called in vitro transcription, by-products occur which can reduce the therapeu
Externí odkaz:
https://doaj.org/article/cb043fdb9f8c4415a1911c2e6e3bab04
Autor:
Ziyin Wang, Egon J. Jacobus, David C. Stirling, Stefanie Krumm, Katie E. Flight, Robert F. Cunliffe, Jonathan Mottl, Charanjit Singh, Lucy G. Mosscrop, Leticia Aragão Santiago, Annette B. Vogel, Katalin Kariko, Ugur Sahin, Stephanie Erbar, John S. Tregoning
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102045- (2023)
The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine
Externí odkaz:
https://doaj.org/article/41e7361041324d99b26eb39f9bd0fb8e
Autor:
Jordan Blum, Alexander Muik, Isil Altintas, Friederike Gieseke, Aras Toker, Esther Breij, Tahamtan Ahmadi, Ugur Sahin, Kristel Kemper, Oezlem Tuereci, Kristina Nuermberger, Sina Fellermeier-Kopf, Andrea Imle, Anna-Lena Krause, Lidia Daszkiewicz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5b2dfbe7a11a49c1a72650313cf5a53d
Autor:
Karsten Pilones, Maria Jure-Kunkel, Homer Adams, Alexander Muik, Tahamtan Ahmadi, Ugur Sahin, Oezlem Tuereci, Kristina Nuermberger, Angelica Sette, Monique Luijten, Maren Köhne, Jasja Wolthoorn, Sina Fellermeier-Kopf
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c8d187155404406aa8c29dcf9f4c0504
Autor:
Patrick Forde, Neru Munshi, Ugur Sahin, Oezlem Tuereci, Akin Atmaca, Petra Rietschel, Dániel Deme, Bala Öven, Erdem Göker, Istvan Lang, Patrick Brück, Michael Wenger, Thomas Schell, Kezi Ünsal-Kaçmaz, Janet Markman, Huyuan Yang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8417f9713f3d4d198f686b47521e32ce
Autor:
Chaitanya Kurhade, Jing Zou, Hongjie Xia, Mingru Liu, Qi Yang, Mark Cutler, David Cooper, Alexander Muik, Ugur Sahin, Kathrin U. Jansen, Ping Ren, Xuping Xie, Kena A. Swanson, Pei-Yong Shi
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1828-1832 (2022)
Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here, we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron
Externí odkaz:
https://doaj.org/article/daff56ad156a43d398c1caae173a8eba
Autor:
Alexander Muik, Bonny Gaby Lui, Jasmin Quandt, Huitian Diao, Yunguan Fu, Maren Bacher, Jessica Gordon, Aras Toker, Jessica Grosser, Orkun Ozhelvaci, Katharina Grikscheit, Sebastian Hoehl, Niko Kohmer, Yaniv Lustig, Gili Regev-Yochay, Sandra Ciesek, Karim Beguir, Asaf Poran, Isabel Vogler, Özlem Türeci, Ugur Sahin
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112888- (2023)
Summary: Evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to the emergence of sublineages with different patterns of neutralizing antibody evasion. We report that Omicron BA.4/BA.5 breakthrough inf
Externí odkaz:
https://doaj.org/article/9beefa8d290946d3b470f10ccdbe5236