Analytical precision, biological variation, and mathematical normalization in high data density metabolomics

Autor: Yevgeniya I. Shurubor, Ugo Paolucci, Bruce S. Kristal, Boris F. Krasnikov, Wayne R. Matson

Publikováno v: Metabolomics. 1:75-85

Metabolic serotypes sensitive to caloric intake may enable sera metabolomic profiles to validate epidemiological parameters and predict disease risk in humans. This long-range goal is complicated by the lack of known state markers and the requirement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d07518d36596ab2a5a9c6cac2a8b53d8
https://doi.org/10.1007/s11306-005-1109-1

Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke–Enhanced Regimen Stroke Trial

Autor: Arthur M. Pancioli, Opeolu Adeoye, Pamela A. Schmit, Jane Khoury, Steven R. Levine, Thomas A. Tomsick, Heidi Sucharew, Claudette E. Brooks, Todd J. Crocco, Laurie Gutmann, Thomas M. Hemmen, Scott E. Kasner, Dawn Kleindorfer, William A. Knight, Sharyl Martini, James S. McKinney, William J. Meurer, Brett C. Meyer, Alexander Schneider, Phillip A. Scott, Sidney Starkman, Steven Warach, Joseph P. Broderick, Joseph Broderick, Scott Janis, Thomas Tomsick, Todd Crocco, Thomas Hemmen, Alex Schneider, Steven Levine, Claudia Moy, K. Michael Welch, Gretchen Tietjen, William R. Clarke, Jordan Bonomo, Erin McDonough, Simona Ferioli, Felipe de los Rios De la Rosa, Daniel Woo, Rachel Garvin, Pooja Khatri, Anna Gensic, Matthew Flaherty, Daniel Kanter, Brett Kissela, Brian Stettler, Jason Mackey, Rhonda Cadena, Shannon Kohake, Laura Heitsch, Samir Belagaje, Achala Vagal, John Hallenbeck, Richard Benson, Amie Hsia, Rakesh Jaitly, Lawrence Latour, John Lynch, Jose Merino, Ravi Menon, Jason Freeman, Alejandro Magadan, Nandakumar Magaraja, Jennifer Jothen, Bonanle Famakin, Shlee Song, Alex Katcheves, Zurab Nadareishvili, Carsen Ritter, William Barsan, Devin Brown, Lewis Morgenstern, Robert Silbergleit, Venkatakrishna Rajajee, Lesli Rusche-Skolarus, Jim Burke, Jeffrey Fletcher, Eric Adelman, Michael Wang, Darin Zahuranec, Brett Cucchiara, Steven Messe, Christina Wilson, Koto Ishida, Michael Mullen, Jonathan Raser, Swaroop Pawar, David Rose, Neelofer Shafi, Igor Rybinnik, Michael McGavery, Lauren Beslow, Lauren Sansing, Latisha Ali, Hermelinda Abcede, Peter Adamczyk, William Buxton, Michael Froehler, Doojin Kim, David Liebeskind, Bruce Ovbiagele, Verna Porter, Neal Rao, Radoslav Raychev, Sarah Song, Jeffrey Saver, Matthew Tenser, Shamsha Velani, Anil Yallapragada, Brett Meyer, Any Guzik, Kiet Loc, Dawn Meyer, Gilda Tafreshi, Jessica Choe, Ajeet Sodhi, Patrick Delaney, Sean Evans, Omar A. Ghausi, Nhu Bruce, Will Neil, Brank Huisa, Andrew Stemer, Reid Taylor, Jeanette Larson, Seth Larson, Rodney Leacock, Subasisni Dash, Robert Eisenstein, Raffi Kapitanyan, Ugo Paolucci, Chirag Shah, Win Toe, John Brick, Owen Lander, Hollynn Larrabee, Joseph Minardi, Allison Tadros, Roger Tillotson, Charles Whiteman, Debra Paulson, Rosanna Sikora, Christopher Cummings, John Foster, Janice Carrozzella, Traci Doellman, Irene Ewing, Jamey Frasure, Emily Goodall, Pamela Kimmel, Judith Spilker, Robert Tamer, Peggy Waymeyer, Joyce Zeigler, Lisa Davis, Saman Farsad, Teresa Morella, Allison Kade, Shirley Frederiksen, Mary Liz, Jean Luciano, Judy Guzy, Ileana Grunberg, Teresa Rzesiewicz, Karen Rapp, Tracy Nanney, Leslie Shell, Margaret Perkins, Cindy Benton, Robin Jones, Lynne Hampton, Claudine Cuento, Rachel Alosky, Stephanie Shepard, Michelle Moccio, Catherine Albrecht, Yaritza Rosario, Deborah Caputo, Stephen Davis, Patricia Altemus, Martha Power, Reyna VanGilder, Jay Sherman, Taura Barr

Background and Purpose— In a previous study, 0.3 and 0.45 mg/kg of intravenous recombinant tissue plasminogen activator (rt-PA) were safe when combined with eptifibatide 75 mcg/kg bolus and a 2-hour infusion (0.75 mcg/kg per minute). The Combined A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b860e2473bebcad13f911363ee57748
https://europepmc.org/articles/PMC3970761/

Abstract 2208: Sex Differences in Ischemic Stroke Mortality

Autor: James S McKinney, Yingzi Deng, Ugo Paolucci, John B Kostis

Publikováno v: Stroke. 43

Introduction--- Stroke is becoming increasingly more prevalent in women. Prior studies of sex differences in stroke mortality have reported variable findings. Although crude stroke fatality is higher in women, this appears to be mediated by age and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65acf1749cc0f7af988f1e7f4c60cb1f
https://doi.org/10.1161/str.43.suppl_1.a2208

Development of biomarkers based on diet-dependent metabolic serotypes: practical issues in development of expert system-based classification models in metabolomic studies

Autor: Ugo Paolucci, Wayne R. Matson, Bruce S. Kristal, Karen E. Vigneau-Callahan, Honglian Shi, Paul E. Milbury

Publikováno v: Omics : a journal of integrative biology. 8(3)

Dietary restriction (DR)-induced changes in the serum metabolome may be biomarkers for physiological status (e.g., relative risk of developing age-related diseases such as cancer). Megavariate analysis (unsupervised hierarchical cluster analysis [HCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3c5b89d60cc293151bda0931247a78
https://pubmed.ncbi.nlm.nih.gov/15669713

Development of biomarkers based on diet-dependent metabolic serotypes: characteristics of component-based models of metabolic serotypes

Autor: Bruce S. Kristal, Wayne R. Matson, Ugo Paolucci, Honglian Shi, Karen E. Vigneau-Callahan

Publikováno v: Omics : a journal of integrative biology. 8(3)

Our research seeks to identify a serum profile, or serotype, that reflects the systemic physiologic modifications resultant from dietary restriction (DR), in part such that this knowledge can be applied for biomarker studies. Direct comparison sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abf134b56c5017f974a2ef506778646
https://pubmed.ncbi.nlm.nih.gov/15669715