Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ugo Gulini"'
Autor:
Livio Brasili, Ugo Gulini, Gianni Sagratini, Silvia Franchini, Piero Angeli, Dario Giardinà, Michela Buccioni, Alessandro Piergentili, Gabriella Marucci
Publikováno v:
Medicinal Chemistry Research. 14:274-296
Geometric cis, trans isomers, derivatives of 2-substituted-1,3-dioxolanes and 2-substituted-1,3-dioxanes were designed and studied as antimuscarinic agents. The synthesized compounds were evaluated as perchlorides and methiodides by functional tests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d35951e971dd38923141d0ef316e52
https://doi.org/10.1007/s00044-005-0139-6
https://doi.org/10.1007/s00044-005-0139-6
Autor:
Gianni Sagratini, Gabriella Marucci, Dario Giardinà, Carlo Melchiorre, Mauro Crucianelli, Michela Buccioni, Piero Angeli, Ugo Gulini
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:1291-1303
A series of beta-chloroethylamines 5--18, structurally related to the irreversible alpha(1)-adrenoceptor antagonist phenoxybenzamine [PB, N-benzyl-N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)amine hydrochloride, 1] and the competitive antagonist WB4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41665199ed998b42f267dae495a7a900
https://doi.org/10.1016/s0968-0896(01)00395-9
https://doi.org/10.1016/s0968-0896(01)00395-9
Synthesis and α1-antagonist activity of new prazosin- and benextramine-related tetraamine disulfides
Autor:
Mauro Crucianelli, Santi Mario Spampinato, Ugo Gulini, Gabriella Marucci, Carlo Melchiorre, Dario Giardinà
Publikováno v:
European Journal of Medicinal Chemistry. 32:9-20
Tetraamine disulfides 1–10 were designed by combining the structural features of benextramine, an irreversibleα1/ga2 adrenoceptor antagonist, and prazosin, a selective competitive α1-antagonist. Their biological profile was assessed by functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f1f65913e7a90320b24dac09b1b5e3
https://doi.org/10.1016/s0223-5234(97)84357-7
https://doi.org/10.1016/s0223-5234(97)84357-7
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:2071-2080
A series of 1,3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthesized and tested as potential muscarinic antagonists. The compounds display moderate to low affinity for the three receptor subtypes M1-M3, with some o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3452ac8c43f7bfca723e7c287fcb0f1
https://doi.org/10.1016/s0968-0896(96)00223-4
https://doi.org/10.1016/s0968-0896(96)00223-4
Autor:
Maurizio Massi, Dario Giardinà, Maria G. Piloni, Giovanni Rafaiani, Carlo Melchiorre, Ugo Gulini, Pierluigi Pompei
Publikováno v:
Journal of Medicinal Chemistry. 36:690-698
Several prazosin-related compounds have been synthesized and evaluated for their blocking activity toward alpha-adrenoreceptors. The structural modification performed on the prazosin structure included the replacement of the piperazine ring with 2,3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2e249ca228109a59ba508026dff9ca
https://doi.org/10.1021/jm00058a005
https://doi.org/10.1021/jm00058a005
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12c084f6726d8f26e9e6496da06a597b
https://doi.org/10.1002/chin.199130210
https://doi.org/10.1002/chin.199130210
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db7e641a241bbc1e0fd0c1b680884785
https://doi.org/10.1002/chin.199244295
https://doi.org/10.1002/chin.199244295
Autor:
Dario Giardinà, Ugo Gulini, Mauro Crucianelli, Santi Mario Spampinato, Carlo Melchiorre, Gabriella Marucci
Publikováno v:
ChemInform. 28
Tetraamine disulfides 1–10 were designed by combining the structural features of benextramine, an irreversibleα1/ga2 adrenoceptor antagonist, and prazosin, a selective competitive α1-antagonist. Their biological profile was assessed by functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75101072632ce422d5efcc897b66d374
https://doi.org/10.1002/chin.199725243
https://doi.org/10.1002/chin.199725243
Autor:
Carlo Melchiorre, Gianni Sagratini, Piero Angeli, Gabriella Marucci, Dario Giardinà, Mauro Crucianelli, Ugo Gulini, Michela Buccioni
Publikováno v:
ChemInform. 33
A series of beta-chloroethylamines 5--18, structurally related to the irreversible alpha(1)-adrenoceptor antagonist phenoxybenzamine [PB, N-benzyl-N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)amine hydrochloride, 1] and the competitive antagonist WB4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a9cea84648fe60db91468c4f5a41c1
https://doi.org/10.1002/chin.200228113
https://doi.org/10.1002/chin.200228113
Autor:
Gianni Sagratini, Dario Giardinà, Michela Buccioni, Piero Angeli, Gabriella Marucci, Carlo Melchiorre, Ugo Gulini, Elena Poggesi
Tamsulosin (-)-1 is the most utilized α(1)-adrenoceptor antagonist in the benign prostatic hyperplasia therapy owing to its uroselective antagonism and capability in relieving both obstructive and irritative lower urinary tract symptoms. Here we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702509a3ed68746826997455d1240024
http://hdl.handle.net/11581/203200
http://hdl.handle.net/11581/203200
