Výsledky vyhledávání - "Ugo Giambarella"

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease

Autor: Shizu Takeda, Ugo Giambarella, Ikuo Nishimoto, Y. Matsuura, T Okamoto, T. Katada, Takashi Matsui, Y Murayama

Publikováno v: The EMBO Journal. 15:3769-3777

APP695 is a transmembrane precursor of Abeta amyloid. In familial Alzheimer's disease (FAD), three mutations V642I/F/G were discovered in APP695, which has been suggested by multiple studies to be a cell surface signaling receptor. We previously repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec5787c68cecb0de25c25cfbe9a2c2e1
https://doi.org/10.1002/j.1460-2075.1996.tb00750.x

Zobrazit plný text záznamu

Cell Surface Receptor Function of Amyloid Precursor Protein That Activates Ser/Thr Kinases

Autor: Etsuro Ogata, Shizu Takeda, Kazuyoshi Yonezawa, Yoshitake Murayama, Ugo Giambarella, Ikuo Nishimoto

Publikováno v: Gerontology. 42:2-11

Amyloid precursor protein (APP) has been shown to serve as a G(o)-coupled receptor in cell-free systems [Okamoto et al: J Biol Chem 1995;270:4205-4208]. However, it has not been known whether APP exerts intracellular signaling functions in living cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76e875871a018d1874f9b070d3b8680
https://doi.org/10.1159/000213818

Zobrazit plný text záznamu

In Vivo Coupling of Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor to Heteromeric G Proteins

Autor: Ikuo Nishimoto, Takashi Yokota, Ugo Giambarella, Takashi Okamoto, Tsuneya Ikezu

Publikováno v: Journal of Biological Chemistry. 270:29224-29228

We examined the signaling function of the IGF-II/mannose 6-phosphate receptor (IGF-IIR) by transfecting IGF-IIR cDNAs into COS cells, where adenylyl cyclase (AC) was inhibited by transfection of constitutively activated Gα cDNA (GαQ205L). In cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf77330a982f55cd843674b3aefaccae
https://doi.org/10.1074/jbc.270.49.29224

Zobrazit plný text záznamu

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP

Autor: Arieh A. Katz, Yoshitake Murayama, Takashi Matsui, Tomoki Yamatsuji, Michael A. Levine, Tsuneya Ikezu, Narasimhan Gautam, Takashi Okamoto, Ugo Giambarella, Ikuo Nishimoto

Publikováno v: The EMBO journal. 16(16)

In familial Alzheimer's disease (FAD), three missense mutations, V642I, V642F and V642G, that co-segregate with the disease phenotype have been discovered in the 695 amino acid form of the amyloid precursor protein APP. Expression of these mutants ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4491bd7299347d5b27cb4ea4e7ea6b1
https://pubmed.ncbi.nlm.nih.gov/9305632

Zobrazit plný text záznamu

Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation

Autor: Ugo Giambarella, Ikuo Nishimoto, Toshiro Fujita, Yoshitake Murayama, Tsuneya Ikezu

Publikováno v: FEBS letters. 412(1)

In familial Alzheimer's disease (FAD), mutations to I, F, and G have been discovered at V642 in the neuron-specific version of the amyloid precursor protein APP695. It has been found that expression of each FAD mutant suppresses the transcriptional a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1393fbfe12795de635c458954d387b93
https://pubmed.ncbi.nlm.nih.gov/9257698

Zobrazit plný text záznamu

A novel system that reports the G-proteins linked to a given receptor: a study of type 3 somatostatin receptor

Autor: Etsuro Ogata, Ikuo Nishimoto, Katsumi Komatsuzaki, Ugo Giambarella, Susumu Seino, Yoshitake Murayama

Publikováno v: FEBS letters. 406(1-2)

SSTR3, a somatostatin (SST) receptor, is an adenylyl cyclase (AC)-inhibiting receptor. To assign the G-protein alpha-subunit (G alpha) linked to this receptor, we created a novel reporter system which utilizes the well-established facts that the C-te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0531ac444e37f28384622f29363d45af
https://pubmed.ncbi.nlm.nih.gov/9109410

Zobrazit plný text záznamu

Apoptosis in Neurodegenerative Diseases

Autor: Ikuo Nishimoto, Takeshi Iwatsubo, Takashi Okamoto, Ugo Giambarella

Publikováno v: Apoptosls-Pharmacological Implications and Therapeutic Opportunities ISBN: 9780120329427

Publisher Summary This chapter reviews pathological features of various neurodegenerative diseases, the relevance of apoptosis in their pathogenesis, and underlying genetic abnormalities. The chapter also describes proposed mechanisms for Alzheimer's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::582e855f23796a1ce302f27505c89d06
https://doi.org/10.1016/s1054-3589(08)61064-9

Zobrazit plný text záznamu

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP

Autor: T. Bernard Kinane, Katsumi Komatsuzaki, Shizu Takeda, Scott Ireland, Takashi Matsui, Ugo Giambarella, Tomoki Yamatsuji, Takeshi Iwatsubo, Nobuhiro Suzuki, Takashi Okamoto, Ikuo Nishimoto, Hiroaki Fukumoto, Asano Asami-Odaka

Publikováno v: Science (New York, N.Y.). 272(5266)

Missense mutations in the 695-amino acid form of the amyloid precursor protein (APP695) cosegregate with disease phenotype in families with dominantly inherited Alzheimer's disease. These mutations convert valine at position 642 to isoleucine, phenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e50c77e70ad5d95ff1e06a377b31c4e
https://pubmed.ncbi.nlm.nih.gov/8650548

Zobrazit plný text záznamu

Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor

Autor: Tsuneya Ikezu, Shuji Takahashi, Takashi Yokota, Ikuo Nishimoto, Ugo Giambarella, Etsuro Ogata, Katsutoshi Takahashi, Yoshitake Murayama, Takashi Okamoto

The 14-residue peptide (peptide 14) corresponding to Arg2410-Lys2423 of the insulin-like growth factor II receptor (IGF-IIR) can activate the adenylate cyclase-inhibitor guanine nucleotide-binding protein Gi, and the 15-residue beta III-2 peptide Arg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346347304174fe41e2e29e331d27d0bd
https://europepmc.org/articles/PMC48066/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání