C-5’-Triazolyl-2’-oxa-3’-aza-4’a-carbanucleosides: Synthesis and biological evaluation

Autor: Roberto Romeo, Caterina Carnovale, Salvatore V. Giofrè, Maria A. Chiacchio, Adriana Garozzo, Emanuele Amata, Giovanni Romeo, Ugo Chiacchio

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 328-334 (2015)

A novel series of 2’-oxa-3’-aza-4’a-carbanucleosides, featured with a triazole linker at the 5’-position, has been developed by exploiting a click chemistry reaction of 5’-azido-2’-oxa-3’-aza-4’a-carbanucleosides with substituted alky

Externí odkaz: https://doaj.org/article/91b80c00827f4e62965183a547d89963

Oxazole-Based Compounds As Anticancer Agents

Autor: Salvatore V. Giofrè, Giuseppe Lanza, Roberto Romeo, Daniela Iannazzo, Ugo Chiacchio, Maria A. Chiacchio, Laura Legnani

Publikováno v: Current Medicinal Chemistry. 26:7337-7371

Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77673dbf0829e3c0958d682be4a121e5
https://doi.org/10.2174/0929867326666181203130402

Conversion of Oximes to Carbonyl Compounds by Triscetylpyridinium Tetrakis(oxodiperoxotungsto) Phosphate (PCWP)-mediated Oxidation with Hydrogen Peroxide

Autor: Rosa M. Toscano, Gaetano Tomaselli, Antonio Rescifina, Ugo Chiacchio, Francesco P. Ballistreri

Publikováno v: Molecules, Vol 13, Iss 6, Pp 1230-1237 (2008)

Aromatic and aliphatic oximes have been deoximated in chloroform-water to the corresponding aldehydes with dilute hydrogen peroxide and triscetylpyridinium tetrakis (oxodiperoxotungsto) phosphate as catalyst. The presence of dipolarophiles in the rea

Externí odkaz: https://doaj.org/article/6d8d98b276f14de4b75acc0c26afb5f1

Enantioselective synthesis of isoxazolidinyl nucleosides containing uracil, 5-fluorouracil, thymine and cytosine as new potential anti-HIV drugs

Autor: Ugo Chiacchio, Antonino Corsaro, Daniela Iannazzo, Anna Piperno, Venerando Pistarà, Antonio Procopio, Antonio Rescifina, Giovanni Romeo, Roberto Romeo, Maria C. R. Siciliano, Enza Valveri

Publikováno v: ARKIVOC, Vol 2002, Iss 11, Pp 159-167 (2002)

Externí odkaz: https://doaj.org/article/cd5a10d0c6a645c3bb4be8851051d5fa

Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of Indicaxanthin

Autor: Agatina Campisi, Giovanni Sposito, Rosalia Pellitteri, Mario Allegra, Michela Spatuzza, Giuseppina Raciti, Alessandro Attanzio, Rosaria Grasso, Luisa Tesoriere, Ugo Chiacchio, Maria A. Chiacchio

Publikováno v: International journal of molecular sciences (Online) 22 (2021). doi:10.3390/ijms22073388
info:cnr-pdr/source/autori:Agata Campisi; Giuseppina Raciti ; Giovanni Sposito; Rosaria Grasso; Maria A. Chiacchio; Michela Spatuzza; Alessandro Attanzio; Ugo Chiacchio; Luisa Tesoriere; Mario Allegra; and Rosalia Pellitteri/titolo:Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of Indicaxanthin/doi:10.3390%2Fijms22073388/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3388, p 3388 (2021)

Alzhèimer Disease (AD) is characterized by protein aggregates in the brain, including amyloid-beta (Aβ), a substrate for tissue transglutaminase (TG2). We assessed the effect of full native peptide of Aβ (1–42), the fragments (25–35 and 35–2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbe7b18b910d3d4ca9f3bebddd06569
https://doi.org/10.3390/ijms22073388