Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Ugo Bastolla"'
Autor:
Fernando Puente-Sánchez, Alberto Pascual-García, Ugo Bastolla, Carlos Pedrós-Alió, Javier Tamames
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The structure of microbial communities arises from a multitude of factors, including the interactions of microorganisms with each other and with the environment. In this work, we sought to disentangle those drivers by performing a cross-stud
Externí odkaz:
https://doaj.org/article/be5292a9ab4049a49b8a40996076070d
Autor:
María Úbeda, María del Carmen Maza, Pilar Delgado, Lydia Horndler, David Abia, Laura García-Bermejo, Sergio Serrano-Villar, Cristina Calvo, Ugo Bastolla, Talia Sainz, Manuel Fresno
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundChildren are less susceptible than adults to symptomatic COVID‐19 infection, but very few studies addressed their underlying cause. Moreover, very few studies analyzed why children highly exposed to the virus remain uninfected.MethodsWe a
Externí odkaz:
https://doaj.org/article/7a70cb17543b45f39a6c54abda5f8be6
Autor:
María del Carmen Maza, María Úbeda, Pilar Delgado, Lydia Horndler, Miguel A. Llamas, Hisse M. van Santen, Balbino Alarcón, David Abia, Laura García-Bermejo, Sergio Serrano-Villar, Ugo Bastolla, Manuel Fresno
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCOVID‐19 can generate a broad spectrum of severity and symptoms. Many studies analysed the determinants of severity but not among some types of symptoms. More importantly, very few studies analysed patients highly exposed to the virus tha
Externí odkaz:
https://doaj.org/article/6e2e21cd90034b56abde7ebc99f67520
Publikováno v:
Frontiers in Drug Discovery, Vol 1 (2022)
Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects the
Externí odkaz:
https://doaj.org/article/ca532afaff72431fa1be445baa31b370
Autor:
Dolores Piniella, Ania Canseco, Silvia Vidal, Clara Xiol, Aránzazu Díaz de Bustamante, Itxaso Martí-Carrera, Judith Armstrong, Ugo Bastolla, Francisco Zafra
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 955 (2023)
In this article, we identified a novel epileptogenic variant (G307R) of the gene SLC6A1, which encodes the GABA transporter GAT-1. Our main goal was to investigate the pathogenic mechanisms of this variant, located near the neurotransmitter permeatio
Externí odkaz:
https://doaj.org/article/0fa48065597b4f24a049889d580fd2e3
Autor:
Ugo Bastolla
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The fatality rate of Covid-19 escalates with age and is larger in men than women. I show that these variations correlate strongly with the level of the viral receptor protein ACE2 in rat lungs, which is consistent with the still limited data on human
Externí odkaz:
https://doaj.org/article/e3fe104d5670437082d255755df183f5
Autor:
Alberto Pascual-García, Ugo Bastolla
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Theoretical ecologists have made disparate predictions regarding the relationship between mutualism and stability. Here, Pascual-García and Bastolla develop a theoretical framework showing that model mutualistic interactions promote structural stabi
Externí odkaz:
https://doaj.org/article/33fc7a27029f43caba4e37a6be9cafe7
Publikováno v:
PeerJ, Vol 6, p e5549 (2018)
The number of amino acids that occupy a given protein site during evolution reflects the selective constraints operating on the site. This evolutionary variability is strongly influenced by the structural properties of the site in the native structur
Externí odkaz:
https://doaj.org/article/987a4c6875ff4f27a127fc056a36e012
Autor:
Ugo Bastolla
Publikováno v:
Biomolecules, Vol 4, Iss 1, Pp 291-314 (2014)
The properties of biomolecules depend both on physics and on the evolutionary process that formed them. These two points of view produce a powerful synergism. Physics sets the stage and the constraints that molecular evolution has to obey, and evolut
Externí odkaz:
https://doaj.org/article/9eff0a94cb734910824dd7146b3a860d
Publikováno v:
PeerJ Computer Science, Vol 2, p e100 (2016)
We propose here a working unit for teaching basic concepts of structural bioinformatics and evolution through the example of a wooden snake puzzle, strikingly similar to toy models widely used in the literature of protein folding. In our experience,
Externí odkaz:
https://doaj.org/article/d3ea52ca6b334b3c87d12f80a0f16c31