Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Ugo, Mayor"'
Autor:
Orhi Barroso-Gomila, Laura Merino-Cacho, Veronica Muratore, Coralia Perez, Vincenzo Taibi, Elena Maspero, Mikel Azkargorta, Ibon Iloro, Fredrik Trulsson, Alfred C. O. Vertegaal, Ugo Mayor, Felix Elortza, Simona Polo, Rosa Barrio, James D. Sutherland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a challenge. We present BioE3, a powerful approach for matching
Externí odkaz:
https://doaj.org/article/4ccb7e7077984547931c1b4504e71284
Autor:
Luis O. Romero, Rebeca Caires, A. Kaitlyn Victor, Juanma Ramirez, Francisco J. Sierra-Valdez, Patrick Walsh, Vincent Truong, Jungsoo Lee, Ugo Mayor, Lawrence T. Reiter, Valeria Vásquez, Julio F. Cordero-Morales
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Angelman syndrome (AS) is a neurogenetic disorder. Here, the authors found that PIEZO2 activity is reduced in sensory neurons from a mouse model of AS and used a linoleic acid-enriched diet to enhance PIEZO2 function and ameliorate AS-associated gait
Externí odkaz:
https://doaj.org/article/664f09f3735d4266a19b95c85b38e994
Autor:
Uxue Balantzategi, Adhara Gaminde-Blasco, Lierni Aizpurua, Juanma Ramírez, Ugo Mayor, Asier Ruiz, Carlos Matute, José Luis Zugaza, Elena Alberdi
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S364- (2023)
Externí odkaz:
https://doaj.org/article/e298065dcca948c5977a904a3edc8d46
Autor:
Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Several proteomic approaches allow the analysis of covalent protein SUMOylation, but it remains challenging to systematically study the consequences of a substrate being modified. Here, the authors combine proximity biotinylation and protein-fragment
Externí odkaz:
https://doaj.org/article/a373110170724930bd012a7ad3fa350e
Autor:
Marina Serrano-Maciá, Jorge Simón, Maria J. González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Fernando Lopitz-Otsoa, Diego Saenz De Urturi, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, Maria Mercado-Gomez, Virginia Gutiérrez de Juan, Maider Bizkarguenaga, David Fernández-Ramos, Xabier Buque, Guido A. Baselli, Luca V.C. Valenti, Paula Iruzubieta, Javier Crespo, Erica Villa, Jesus M. Banales, Matias A. Avila, Jose J.G. Marin, Patricia Aspichueta, James Sutherland, Rosa Barrio, Ugo Mayor, Félix Elortza, Dimitris P. Xirodimas, Rubén Nogueiras, Teresa C. Delgado, María Luz Martínez-Chantar
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101275- (2021)
Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein
Externí odkaz:
https://doaj.org/article/358512f74108488aa4daf723e0bda944
Publikováno v:
Open Biology, Vol 10, Iss 5 (2020)
SUMOylation—protein modification by the small ubiquitin-related modifier (SUMO)—affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is in
Externí odkaz:
https://doaj.org/article/946d77691a644f03bebe7bafffe081d4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein. Numerous diseases are caused by defects in the ubiquitin-proteasome machinery, incl
Externí odkaz:
https://doaj.org/article/952b40603ecd4c8d9e0f2d1d39f2b7eb
Autor:
Áron Szabó, Christian Papin, David Cornu, Elisabeth Chélot, Zoltán Lipinszki, Andor Udvardy, Virginie Redeker, Ugo Mayor, François Rouyer
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2273-2282 (2018)
Summary: Circadian clocks have evolved as time-measuring molecular devices to help organisms adapt their physiology to daily changes in light and temperature. Transcriptional oscillations account for a large fraction of rhythmic protein abundance. Ho
Externí odkaz:
https://doaj.org/article/a870a8584ee54d4d8dac878ec5c5938e
Autor:
Amaia Mendoza, Galder Kortaberria, Florencio F. Marzo, Ugo Mayor, Oihane C. Basurko, Cristina Peña-Rodriguez
Publikováno v:
Environments, Vol 8, Iss 7, p 68 (2021)
The physical-chemical characterization of plastic litter from the marine environment requires the prior removal of the biofouling attached to their surface without causing any degradation in the polymer. The absence of a standardized protocol for dig
Externí odkaz:
https://doaj.org/article/c821247d3bce47a1b76de1ace2ed2cbd
Autor:
Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague, Ugo Mayor
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Abstract Background Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity le
Externí odkaz:
https://doaj.org/article/27faf3193c6f4049a8c444845e938b87