Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ufuk Karakus"'
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104539- (2023)
Summary: Background: The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells. The ability of selectively engaging either of these effects has spurred interest in using IL-2 for immunotherapy of cancer
Externí odkaz:
https://doaj.org/article/6f24eb0b735344ddbb97e4d54971d983
Autor:
Alexandar Tzankov, Nicole Joller, Onur Boyman, Anne Müller, Kristin Stirm, Peter Leary, Daria Wüst, Dominique Stark, Ufuk Karakus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Roughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by large numbers of regulatory T-cells (Tregs). Although the presence of ‘effector’ Tregs in particular is associated with an inferior prognosis in patients on
Externí odkaz:
https://doaj.org/article/19fcfd9206c14d5299cc560537d38cce
Autor:
Dilara Sahin, Natalia Arenas-Ramirez, Matthias Rath, Ufuk Karakus, Monika Hümbelin, Merel van Gogh, Lubor Borsig, Onur Boyman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a
Externí odkaz:
https://doaj.org/article/bccae141645e49d6828a1fe5efe66a25
Autor:
Olga Murina, Christine von Aesch, Ufuk Karakus, Lorenza P. Ferretti, Hella A. Bolck, Kay Hänggi, Alessandro A. Sartori
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1030-1038 (2014)
The resolution of DNA interstrand crosslinks (ICLs) requires a complex interplay between several processes of DNA metabolism, including the Fanconi anemia (FA) pathway and homologous recombination (HR). FANCD2 monoubiquitination and CtIP-dependent DN
Externí odkaz:
https://doaj.org/article/988e5ca39e1a4d99a128e310b7eac278
Publikováno v:
Science Translational Medicine. 12
Stimulation of regulatory T (Treg) cells holds great promise for the treatment of autoimmune, chronic inflammatory, and certain metabolic diseases. Recent clinical trials with low-dose interleukin-2 (IL-2) to expand Treg cells led to beneficial resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1f0fcc676d0081e0af1c7ff7c4dffa
https://doi.org/10.1126/scitranslmed.abb9283
https://doi.org/10.1126/scitranslmed.abb9283
Autor:
Onur Boyman, Mamiko Ninomiya, Claudia E. Murar, Ufuk Karakus, Satomi Shimura, Jeffrey W. Bode
Publikováno v:
Angewandte Chemie. International Edition, 59 (22)
Angewandte Chemie. International Edition, 59 (22)
ISSN:1433-7851
ISSN:1521-3773
ISSN:0570-0833
ISSN:1433-7851
ISSN:1521-3773
ISSN:0570-0833
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daa47d6b59c2db2731a412c75763417
https://doi.org/10.5167/uzh-200292
https://doi.org/10.5167/uzh-200292
Publikováno v:
Science translational medicine. 12(561)
Tumor-infiltrating dendritic cells (DCs) correlate with effective anticancer immunity and improved responsiveness to anti-PD-1 checkpoint immunotherapy. However, the drivers of DC expansion and intratumoral accumulation are ill-defined. We found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad4456f2ade282a3e027bf08adb4fce
https://pubmed.ncbi.nlm.nih.gov/32938795
https://pubmed.ncbi.nlm.nih.gov/32938795
Autor:
Ufuk KARAKUŞ
Publikováno v:
Zeitschrift für die Welt der Türken, Vol 5, Iss 1, Pp 233-246 (2013)
This study aims at the use of photography as a teaching technique in geography education. The subject of the study was the demographical and functional changes of the cities taught in the human systems unit of the 11th year geography course. The stud
Externí odkaz:
https://doaj.org/article/9ed449e621eb40b193b36603cdf3fbd9
Autor:
Murat KEÇE, Ufuk KARAKUŞ
Publikováno v:
Zeitschrift für die Welt der Türken, Vol 4, Iss 3, Pp 131-145 (2012)
In this study, it has been analyzed that the perception of the natural environment and the importance of environmental education over the Turks in Turkish proverbs which is one of the important building blocks of folk culture. In the introduction, af
Externí odkaz:
https://doaj.org/article/4ca6d92f00694c1d92decc895a3d9178